Alterações no equilíbrio ácido-base em equinos submetidos à prova de três tambores ou à competição de enduro de 160 Km

Pós-graduação em Medicina Veterinária - FCAV

Dinitrosyl iron complexes with cysteine. kinetics studies of the formation and reactions of dnics in aqueous solution

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Escola e o diálogo sobre corporeidade e educação sexual

The purpose of this work and to provide education professionals regarding the way a reflection of how the body has been seen and treated at school. In view of embodiment and sexuality education body and movement performed by him has received a new treatment in our time, overcoming the dichotomy inherited from the mechanistic paradigm and structured by Newton and Descartes and predominant in recent centuries. We know that these changes are consequences of the emergence of AIDS and the advancement of the incidence of unwanted pregnancies among young people of school age. Therefore, this discussion reinforces the need for training of teachers in promoting discussions about sexuality and corporeality with broader focus, dialogues, be traced paths to address the biopsychosocial aspects from a sociohistorical context of gender equity, respect for sexual diversity, the reduction of prejudice and violence against the so-called “minorities” sex.

A comparison of mucosal surface area and villous histology in small intestines of the brazilian free-tailed bat (Tadarida brasiliensis) and the mouse (Mus musculus)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Metabolomics method to comprehensively analyze amino acids in different domains

Amino acids play essential roles in both metabolism and the proteome. Many studies have profiled free amino acids (FAAs) or proteins; however, few have connected the measurement of FAA with individual amino acids in the proteome. In this study, we developed a metabolomics method to comprehensively analyze amino acids in different domains, using two examples of different sample types and disease models. We first examined the responses of FAAs and insoluble-proteome amino acids (IPAAs) to the Myc oncogene in Tet21N human neuroblastoma cells. The metabolic and proteomic amino acid profiles were quite different, even under the same Myc condition, and their combination provided a better understanding of the biological status. In addition, amino acids were measured in 3 domains (FAAs, free and soluble-proteome amino acids (FSPAAs), and IPAAs) to study changes in serum amino acid profiles related to colon cancer. A penalized logistic regression model based on the amino acids from the three domains had better sensitivity and specificity than that from each individual domain. To the best of our knowledge, this is the first study to perform a combined analysis of amino acids in different domains, and indicates the useful biological information available from a metabolomics analysis of the protein pellet. This study lays the foundation for further quantitative tracking of the distribution of amino acids in different domains, with opportunities for better diagnosis and mechanistic studies of various diseases.

Evolution of the Metazoan Mitochondrial Replicase

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Catastrophic regime shift in water reservoirs and São Paulo water supply crisis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

PE and PS lipids synergistically enhance membrane poration by a peptide with anticancer properties

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

O ensino de física e a curiosidade epistemológica: o uso de experimentos de eletricidade em atividades educacionais

We analyzed with this work the importance of using experiments in the classroom, especially the low-cost experiments for better learning of Physics, discussing the context where this discipline is inserted, which in general, has been presented to students in a traditional, mechanistic way. We worked with the electrostatic theme and low cost didactic experiments, focusing on the pizza electrophorus. About the handling of this experiment, we can see the surprise and curiosity in students, depending on how it is used in didactic activities in order to make it meaningful to the student. We discussed how the curiosity can be harnessed in the classroom, the types of curiosity according to Freire, how to overcome the curiosity to become epistemological, the physics involved in the experiment and the teacher's role in this context

Estudo sobre as respostas diferenciadas de 3 espécies de roedores à fragmentação da Mata Atlântica, utilizando uma abordagem integrativa do balanço hídrico

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A teoria, a prática, o professor e a educação ambiental: algumas reflexões

The acceleration of economic and scientific development caused by the production system and mechanistic science, have created new power structures and new political and social problems, including environmental ones, consolidating a period of widespread crisis in different spheres of society. In this context, reflection about the major causes of environmental problems is necessary in the field of environmental education. Therefore, considering that the current environmental crisis is directly related to the mode and the devices of production of the capitalist system, initiatives on environmental education should reflect, from a historical and dialectical process, on what is advocated by capitalist society. Considering the various theoretical-practical concepts and approaches in environmental education, the principles of Critical Environmental Education can provide conditions to confront the structural crisis that we are facing, through the educational process. It is a political process of reflection and critical appropriation of knowledge, attitudes, values and behaviors that aims to contribute to build a sustainable society from the social and environmental points of view. We intend to articulate it through the theoretical formulations of Historical-Critical Pedagogy with the purpose of presenting a reflection that may contribute to a pedagogic response to environmental issues, especially regarding the formation of teachers who develop projects in schools. Thus, this present study intends to highlight the contributions of the philosophy of praxis in the formation of environmental educators, grounded in theoretical aspects of Critical Environmental Education.

O conhecimento biológico nos documentos curriculares nacionais do ensino médio: uma análise histórico-filosófica a partir dos estatutos da biologia

We analyzed the National Curriculum for Secondary Schools with respect to the ontological, epistemological, historical, social and conceptual biology. This study aims to bring information and thinking about the inclusion of history and philosophy of biology for secondary education and for teacher training. We performed an analysis of PCNEM, PCNEM+ and Curriculum Guidelines as a whole from established categories. The results indicate a predominance of the ontological view of mechanistic biology. Epistemologically, although acknowledged, the question of scientific method is rarely discussed. The historical approach and social scientific activity and scientific knowledge are recognized by the documents, but an instrumental view prevails. The conceptual aspects are comprehensive and take into account the theories of structural biology. A philosophical discussion on the biology is missing in the parameters, indicating the need for the inclusion of issues related to ideas of determinism, chance and teleology.

Study of visceral antinociceptive potential of bee Apis mellifera venom

Pain is one of the most common reasons for patients to seek medical care. Bee Apis mellifera venom (AMV) has traditionally been used to treat inflammatory diseases and the alleviation of pain. Herein, we aimed to investigate the visceral antinociceptive potential of A. mellifera bee venom and its possible mechanism of action. Acetic acid-induced writhing assay was used in mice to determine the degree of visceral antinociception. Visceral antinociceptive activity was expressed as the reduction in the number of abdominal constrictions. Mice received an intraperitoneal injection of acetic acid after administration of AMV (0.08 or 0.8 mg/kg; intraperitoneally (i.p.)). In mechanistic studies, separate experiments were realized to examine the role of α2-receptors, nitric oxide, calcium channels, K+ATP channel activation, TRPV1 and opioid receptors on the visceral antinociceptive effect of AMV (0.8 mg/kg), using appropriate antagonists, yohimbine (2 mg/kg), L-NG-Nitroarginine methyl ester (L-NAME, 10 mg/kg), verapamil (5 mg/kg), glibenclamide (5 mg/kg), ruthenium red (3 mg/kg) or naloxone (2 mg/kg). AMV presented visceral antinociceptive activity in both doses tested (0.08 and 0.8 mg/Kg). Visceral antinociceptive effect of AMV was resistant to all the antagonists used. Mice showed no significant alterations in locomotion frequency, indicating that the observed antinociception is not a consequence of motor abnormality. Although AMV efficient diminished the acetic acid-evoked pain-related behavior, its mechanism is unclear from this study and future studies are needed to verify how the venom exerts its antinociceptive action.

O desafio da qualificação para o trabalho na perspectiva do Proeja no IFMT: política, fato e possibilidades

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)