eIF5A and EF-P: two unique translation factors are now traveling the same road

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

E o homem que murmura contra o ensinamento secreto da Yahad será expulso e não mais voltará (1QS 7:17): a expulsão na comunidade judaica do mar Morto

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Famílias com gêmeos: um estudo sobre o relacionamento fraterno e a dinâmica das relações familiares

Pós-graduação em Psicologia do Desenvolvimento e Aprendizagem - FC

The puzzle assembled: Ediacaran guide fossil Cloudina reveals an old proto-Gondwana seaway

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Tissue-engineering-based Strategies for Regenerative Endodontics

Stemming from in vitro and in vivo pre-clinical and human models, tissue-engineering-based strategies continue to demonstrate great potential for the regeneration of the pulp-dentin complex, particularly in necrotic, immature permanent teeth. Nanofibrous scaffolds, which closely resemble the native extracellular matrix, have been successfully synthesized by various techniques, including but not limited to electrospinning. A common goal in scaffold synthesis has been the notion of promoting cell guidance through the careful design and use of a collection of biochemical and physical cues capable of governing and stimulating specific events at the cellular and tissue levels. The latest advances in processing technologies allow for the fabrication of scaffolds where selected bioactive molecules can be delivered locally, thus increasing the possibilities for clinical success. Though electrospun scaffolds have not yet been tested in vivo in either human or animal pulpless models in immature permanent teeth, recent studies have highlighted their regenerative potential both from an in vitro and in vivo (i.e., subcutaneous model) standpoint. Possible applications for these bioactive scaffolds continue to evolve, with significant prospects related to the regeneration of both dentin and pulp tissue and, more recently, to root canal disinfection. Nonetheless, no single implantable scaffold can consistently guide the coordinated growth and development of the multiple tissue types involved in the functional regeneration of the pulp-dentin complex. The purpose of this review is to provide a comprehensive perspective on the latest discoveries related to the use of scaffolds and/or stem cells in regenerative endodontics. The authors focused this review on bioactive nanofibrous scaffolds, injectable scaffolds and stem cells, and pre-clinical findings using stem-cell-based strategies. These topics are discussed in detail in an attempt to provide future direction and to shed light on their potential translation to clinical settings.

Análise microestrutural de tubos API P110, para prospecção de petróleo e gás, soldados pelo processo HF/ERW

On the grounds of the great advances achieved over recent years, the process HF/ERW (High-Frequency/Electric Resistance Welding)welded pipe have played an active role in the oil and gas industry for deep water applications, at high and extremely low temperatures, under high pressure and in highly corrosive environments, gradually replacing manufactured pipes by other processes. However, studies have shown that defects in the welded joints are a the leading causes of pipelines failures, which has required the determination of toughness values in this region, in compliance with the strict recommendations of the codes and standards with manufacturers and construction companies, on the oil and gas sector. As part of the validation process required toughness values, this research project focuses on a microstructural analysis in HF / ERW tubes microalloyed, steel grade API 5CT P110, designed to explore oil and gas in deep waters, the subject of strategic relevance to the country because of the recent discoveries in the Santos mega fields: Tupi and Libra (pre-salt). In this scientific work will be presented and discussed the results of mechanical tensile and Charpy, a few CTOD tests curves (showing the trend of toughness values to be obtained), and the microstructures of the base material obtained by optical microscopy, with special emphasis on the formation of nonmetallic inclusions in the welded joint

Análise da prática de meditação em duas escolas do município de Rio Claro - SP

Nowadays, meditation had become larger than the mystic’s scope, entering the academy through the scientific interest in this topic. Results documented for so many centuries or the experienced monks that practice meditation for a long time are the aims for researches that want, ultimately, establish the real effects of such techniques upon the human body. Research has gone far, and many effects can be evaluated using more precise methods, specially in the medical field and neuroscience, which had greatly backed up new discoveries about the correlation between the mind, emotions, thoughts and the body, making so that mediation can walk the therapeutic ways and complementary health with more certainty and reliable results, as it is happening with acupuncture and yoga. Facing a promising scenario in the correlation between meditation and life’s quality, well being sensation and happiness, there is the possibility of using it in schools, since because of the difficulties and present challenges, those factors are not commonly associated with the acts of teaching and learning, and acupuncture and Yoga have more restrictions because of their own limitations of time and space necessary for their wide application. Therefore, the current study focused on contextualizing the meditation’s fundaments in the scientific perspective, and apply it, even if qualitatively, in two schools of Rio Claro municipality, researching 57 students from Educação de Jovens e Adultos (EJA). Therefore, it was chosen only one meditation tecnique to be applied on the treatment group. As for the control group, it perfomed normal breathing, i.e., without tecniques. The differences were then analyzed through the filmings of all the sessions of the meetings, counting the number of movements and the agitation among the students for the two groups. Another method of analysis was forms filled by both groups and the presence in a meeting at Unesp – Rio Claro. At the end,...

Geologia e pesquisa mineral na região oeste do maciço Caritianas, municípios de Alto Paraíso e Itapuã D'Oeste, Rondônia

The granites Rondonianos, located in Rondônia Tin Pronvíncia, the southwestern portion of the Amazonian Craton, have great economic importance due to its large potential metallogenic. These granites stands out Intrusive Suite or Suite Granites Latest Rondônia Rondônia, with approximately 997-998 Ma (Bettencourt et al., 1997, 1999), for their tin mineralization having the largest reserves of this ore from Brazil. These tin mineralization in veins greissen are genetically related to these granites, deposits with different structural styles both within granitic plutons (endogreissen) as the host rocks (exogreissen). The western region of the Massif Caritianas has few published works, and the geology and potential econômicoão that were never fully known, now with the recovery of tin in the world market need new campaigns and prospective discoveries of new deposits

Diretrizes para execução dos estudos geológico-geotécnicos e ambientais voltados à implantação de dutovias

Due to the new discoveries of oil and gas reservoirs, and also the increasing production of bio-fuels, the brazilian general pipeline system is being vertiginously extended. On the other hand, there is a lack of clear parameters that would allow a better utilization of the geological-geotechnical studies in the process of environmental licensing of pipeline systems. Therefore, this paper presents guidelines that would orientate the environmental licensing procedures to build pipeline systems, and also the geological-geotechnical studies that would support the characterization of the physical context. The method applied in this study consisted in the existing data survey and in their organization, analysis and review. In doing so, there is a well-subsidy integration of the many steps of the pipeline system implementation, the required environmental licenses and the investigation methods of the correlated physical context. As a result, it’s presented a flowchart of the guidelines, detailing the interaction between the environmental licensing, the geological-geotechnical studies and the phases of the pipeline’s project.

Análise microestrutural de tubos API N80 soldados pelo processo HF/ERW para prospecção de petróleo e gás

On the grounds of the great advances achieved over recent years, the process HF/ERW (High-Frequency/Electric Resistance Welding)welded pipe have played an active role in the oil and gas industry for deep water applications, at high and extremely low temperatures, under high pressure and in highly corrosive environments, gradually replacing manufactured pipes by other processes. However, studies have shown that defects in the welded joints are a the leading causes of pipelines failures, which has required the determination of toughness values in this region, in compliance with the strict recommendations of the codes and standards with manufacturers and construction companies, on the oil and gas sector. As part of the validation process required toughness values, this research project focuses on a microstructural analysis in HF / ERW tubes microalloyed, steel grade API 5CT N80, designed to explore oil and gas in deep waters, the subject of strategic relevance to the country because of the recent discoveries in the Santos mega fields: Tupi and Libra (pre-salt). In this scientific work will be presented and discussed the results of mechanical tensile and Charpy, a few CTOD tests curves (showing the trend of toughness values to be obtained), and the microstructures of the base material obtained by optical microscopy, with special emphasis on the formation of non-metallic inclusions in the welded joint

Uma proposta de sequência didática para o ensino de Programação Linear no Ensino Médio

Pós-graduação em Matemática em Rede Nacional - IBILCE

Desenvolvimento do cultivo 3D a partir de células primarias de neoplasias mamárias caninas: estudo da apoptose sobre efeito ou não da carboplatina

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

O lúdico no desenvolvimento infantil: um estudo teórico

It is a fact that childhood is a period of play and it is through them that the child meets their interests, express their way to organize, disorganize, build, think, making new discoveries. Therefore, the playful stands as one of the most important and effective in children's learning process forms, as it enables the development of imagination, feelings and fantasies, helping the child progress in their motor, psychomotor, cognitive, and physical skills emotional. This gives her the exercise of attention and memory to play activities adults engage, thus expanding their knowledge about the world. The teacher's role in this process is essential, where it can bring to everyday life of the child in various situations themes, turning the simple play on continuous learning and not just using the play as a complementary activity to the child because they provide pleasure and relaxation which do interact with the new learning and the group operates. The psychology emphasizes that play is essential to the balanced development of the psychosocial human being, because when in childhood, the relationship with the toy and gaming in general develops affectivity, creativity, and reasoning ability. Playing, the child increases their independence by building their knowledge. The aim of this work is to make a theoretical study based on a literature search, aiming to understand the play within the child development process, where it is recognized as very important in a child's learning starting from the theoretical conceptions of thinkers such as Piaget, Vygotsky, Wallon among others. With this, it can also be possible to recover the importance of the play that is being extracted from the infant universe due to new reasons to experience the modern world brings, as the excess number of activities assigned to the child, electronic games, etc. Finally, a playful approach to provide a reflection for parents and educators, bringing children's learning...

Advanced Molecular Surveillance of Hepatitis C Virus

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Investigation, expression, and molecular modeling of ORF2, a metagenomic lipolytic enzyme

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)