Synthesis and characterization of alpha-nickel (II) hydroxide particles on organic-inorganic matrix and its application in a sensitive electrochemical sensor for vitamin D determination

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Ações judiciais de Plínio, o jovem, no Tribunal dos Centúnviros e na Corte Senatorial (séculos I-II d.C.)

Pós-graduação em História - FCHS

Oneirokritika de Artemidouro de Daldis (séc. II D. C.): livros de análise de sonhos - livro V

Pós-graduação em Linguística e Língua Portuguesa - FCLAR

Structural insights into substrate binding of brown spider venom class II phospholipases D

Phospholipases D (PLDs), the major dermonecrotic factors from brown spider venoms, trigger a range of biological reactions both in vitro and in vivo. Despite their clinical relevance in loxoscelism, structural data is restricted to the apo-form of these enzymes, which has been instrumental in understanding the functional differences between the class I and II spider PLDs. The crystal structures of the native class II PLD from Loxosceles intermedia complexed with myo-inositol 1-phosphate and the inactive mutant H12A complexed with fatty acids indicate the existence of a strong ligand-dependent conformation change of the highly conserved aromatic residues, Tyr 223 and Trp225 indicating their roles in substrate binding. These results provided insights into the structural determinants for substrate recognition and binding by class II PLDs.

Os elementos religiosos nas sátiras do poeta Juvenal (séculos I e II d.C)

Pós-graduação em História - FCLAS