Farmacovigilância no Brasil: A relação entre polimorfismo de fármacos, efetividade e segurança dos medicamentos

In spite of the stated Brazilian policy on medicines that their quality, effectiveness and safety should be ensured at reasonable cost, hospitals in the ANVISA Surveillance Network have been receiving notifications of technical complaints, adverse reactions and suspected therapeutic ineffectiveness (STI) of medicines. The purpose of this study was to identify the medicines notified for suspicion of therapeutic ineffectiveness, at a university hospital participating in the national Surveillance Network, and to investigate the existence of polymorphs of any of the drugs involved, by examining the literature. There were 31 notifications of STI in a period of 18 months, concerning 11 different drugs, all of which were 'similar' drugs (neither original nor licensed by originator); five of these could contain polymorphs, according to the literature. However, this does not mean that the other drugs could not contain some unknown polymorphs, more studies being needed on polymorphism, especially in the cases of reported therapeutic ineffectiveness. Therefore, tests of polymorphism should be made part of the routine quality control of the raw materials during the development of medicines and in the studies of pharmaceutical equivalence to 'reference' medicines (innovative brands). The stability test should also involve a study of polymorphism, in order to confirm the solid state stability of the drug. All these measures will assure the effectiveness of medicines, since the reproducibility in the quality of pharmaceutical products could be monitored, as well as the equivalence of each production batch with the batch selected to determine the bioequivalence with the reference brand.

Efetividade dos aparelhos intrabucais de avanço mandibular no tratamento do ronco e da síndrome da apneia e hipopneia obstrutiva do sono (SAHOS): Revisão sistemática

Introduction: The snoring is produced by the vibration of the soft palatum and/or other oropharyngeal tissues, during the air passage, in the breathing function. OSAHS is defined as the closing of 30%, at least, of the nasal/ buccal airway for 10 seconds or more, in spite of existing inspiratory effort, accompanied by oxyhemoglobin de- saturation of 4% or more. Objectives: To evaluate the available scientific evidence about the use of mandibular advancement intraoral appliances in the treatment of the snoring and/or OSAHS. Methodology: Electronic search strategy using predefined key-words and criteria was realized including studies published until October of 2008. It was also used the qualitative evaluation of the articles methodology. Results: Although a significant number of articles has studied this subject, only 7 articles showed methodological quality to be included in this systematic review. Conclusions: The intraoral appliances are widely prescribed for the treatment of snoring and OSAHS as primary therapy and as an alternative to patients who are unable to tolerate the positive airway pressure therapy.

Consumo e custo de energia elétrica na cultura de citros irrigado por gotejamento e microaspersão, com três lâminas de água

The objective of this work was to analyze the consumption, electric energy cost, and economic results of irrigated citrus (Citrus sinensis). The treatments consisted of a dripping irrigation system with one and two lateral distribution lines, a micro sprinkler irrigation system and a treatment without irrigation. For each irrigation system, three water depths were used: 100%, 75% and 50% of Etc (citrus evapotranspiration). The electric energy cost for two tariff groups, Group A and Group B, was studied. For Group A, the expenses with energy were determined for the Conventional Binomial Structure tariff, the Hour-seasonal tariff (green and blue) and the special tariff for nocturnal irrigation. The kWh cost for the tariff systems were obtained from the website of CPFL (São Paulo State Power and Light Company, Brazil). The best relation between the electric energy consumption (kWh.ha -1) and productivity (t.ha -1) occurred in the treatment irrigated with 50% of the Etc. The irrigated treatments increased productivity. The biggest productivity was observed in the irrigation treatments with 50% of the Etc when compared to the ones with 100% of the Etc. The blue and green Hour-seasonal tariff system of Group A (nocturnal irrigation) was the best option. A biggest economic turnover occurred in the treatments irrigated with 50% of the Etc.

Custo de produção e indicadores de rentabilidade da cultura do milho safrinha

The objective of this study was to evaluate the production cost and profitability of the second season corn crop in the Medio Paranapanema region, São Paulo State Brazil, under two technological levels (middle and high technology), crop 2008/2009, and compare the results with the 2006/2007 agricultural year. Effective and total operational cost as well as five profitability indicators were used. It was concluded that the high technology production cost for corn crop (direct seedling, sowing during the recommended period, use of simple hybrid seed, application of side-dressing fertilization, and treatment of seeds with different insecticides) was superior to the middle technology production cost (direct seedling, sowing after the recommended time, use of double hybrid seed, and no side-dressing fertilization). However, the average cost was inferior (US$ 8.5), due to a higher yield (4 t). The high technology corn crop was profitable (gross income and profitability index of 14% and 12%, respectively). For the middle technology crop, profitability indexes pointed out that the cropping system needs to be reevaluated by technicians and research institutions, regarding the adequate technical recommendations. Profitability indexes decreased considerably in both cropping systems. It was verified that, in relation to the 2006/2007 harvest period, the total operational cost increased for both technologies, mainly because of the increase of supplies prices.

Tamanho de amostra e estimativa de custo em levantamento epidemiológico de cárie dentária

This study aimed to analyze how the prevalence and the distribution of dental caries influence the sample size in epidemiological surveys, and how much are the costs. Secondary data of oral health surveys in 12-year-old schoolchildren from Bauru in 1976, 1984, 1990, 1994, and 2001, and from Piracicaba in 2001 and 2005 were studied. Sample sizes were estimated taking into account the mean DMFT and standard deviation of each survey, establishing sampling errors of 1%, 2%, 5%, and 10%. Costs were estimated considering permanent material, consumption material and human resources. The sample size in both towns needed to be increased, ranging from 119 in 1976 to 1,118 in 2001 in Bauru, and from 954 in 2001 to 1,252 in 2005 in Piracicaba, when a sampling error of 10% was considered. The cost of dental caries surveys was verified considering different sampling errors. This cost depends on how acceptable is the margin of difference between the true mean and the one found in the survey. In conclusion, the reduction in the prevalence of dental caries has determined the need for increase in sample size and in costs for conducting the surveys.

Fontes de carbono de baixo custo para a produção de xilanase termoestável por aspergillus niger

A strain of the flamentous fungus Aspergillus niger was isolated and shown to possess extracellular xylanolytic activity. These enzymes have biotechnological potential and can be employed in various industries. This fungus produced its highest xylanase activity in a medium made up of 0.1% CaCO3, 0.5% NaCl, 0.1% NH4Cl, 0.5% corn steep liquor and 1% carbon source, at pH 8.0. A low-cost hemicellulose residue (powdered corncob) proved to be an excellent inducer of the A. niger xylanolytic complex. Filtration of the crude culture medium with suspended kaolin was ideal for to clarify the extract and led to partial purifcation of the xylanolytic activity. The apparent molecular mass of the xylanase was about 32.3 kDa. Maximum enzyme activity occurred at pH 5.0 and 55-60oC. Apparent Km was 10.41 ± 0.282 mg/mL and Vmax was 3.32 ± 0.053 U/mg protein, with birchwood xylan as the substrate. Activation energy was 4.55 kcal/mol and half-life of the crude enzyme at 60oC was 30 minutes. Addition of 2% glucose to the culture medium supplemented with xylan repressed xylanase production, but in the presence of xylose the enzyme production was not affected.

Programação, conexão e avaliação de psicrômetro aspirado de termopar de baixo custo em micrologger para estudos agrometeorológicos

As the psychrometric method is considered standard for the measurement of relative humidity, many studies have used aspirated thermocouple psychrometers connected to microloggers but, however, they do not detail how the aspiration of the air stream is done. However, one of the major difficulties of aspirated thermocouple psychrometers is to program and to connect it in micrologger, because specific programming and connection are requires, and still some skills in getting accurate measurements. This work aimed to provide the programming and the connection of the aspirated thermocouple psychrometer type T for the CR10X microloggers and CR23X of Campbell Scientific, evaluating the quality of measurements of temperature and air relative humidity in relation the a sensor Vaisala HMP50. The non-continuous measurements were made in the period 2006/09/04 to 2007/07/11 at Jaboticabal, SP. The air temperature measurements were similar between the Vaisala sensors and aspirated thermocouple psychrometer, but the relative humidity measurements were significantly different. The measurements obtained by the aspirated thermocouple psychrometer connected to CR10X micrologger were the most accurate. Using the programming and connection of a micro-fan to suck in the dry and moist bulbs of aspirated thermocouple psychrometer in microloggers models CR10X and CR23X, it is possible to obtain measurements of air temperature with good precision and accuracy, and measurements of air relative humidity with good precision, but accuracy is not always attainable due to the difficulties inherent to the physical processes that occur in the wet bulb, the skill in the use and maintenance of this equipment and the reservoir protection against radiative effects.

Avaliação de uma metodologia de baixo custo para o cadastro de propriedades em áreas de expansão e vazios urbanos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Desenvolvimento de um sistema de medição de baixo custo para a monitoração de alimentadores aéreos de distribuição de energia elétrica da classe 15 KV

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Métodos híbridos de pontos interiores e de programação inteira 0-1 para problemas de custo de colheita da cana-de-açúcar e de custo de coleta e geração de energia relacionados à sua biomassa

Pós-graduação em Engenharia Elétrica - FEB

Diabetes mellitus tipo 2 e esquema terapêutico: impacto da prática de atividades físicas sobre o custo do tratamento ambulatorial em Unidade Básica de Saúde da cidade de Bauru -SP

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Relação de custo/benefício na interação entre a aranha Peucetia flava (Oxyopidae) e a planta Rhynchanthera dichotoma (Melastomataceae)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Frugivoria e efetividade de dispersão de sementes dos últimos grandes frugívoros da Mata Atlântica: a anta (Tapirus terrestris) e o muriqui (Brachyteles arachnoides)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Algoritmo genético na otimização do custo de colheita e transporte da cana-de-açúcar

Pós-graduação em Biometria - IBB