Efeito do envelhecimento e do estresse crônico sobre a reação do tecido conjuntivo subcutâneo: estudo histológico em ratos

Physiological functions undergo a gradual retardation that begins around 25-30 years and extends to the death. Moreover, this change affects most severely the activities more complex and more intricate responses to tensions or stress. The purpose of this study was to evaluate histologically in aged rats the effect of chronic stress on the reaction of subcutaneous connective tissue. The purpose of this study was to evaluate histologically in aged rats the effect of chronic stress on the reaction of subcutaneous connective tissue. For this purpose, 60 rats were divided into four groups (GI (control), GII (stressed), GIII (elderly) and GIV (aged / stressed) received dorsal subcutaneous implants of polyethylene tubes containing saline solution. In groups of four animals were sacrificed at 7,14 and 28 days postoperatively. The results allowed to observe more intense inflammatory reaction and tissue organization later in the aged animals subjected to stress.

Variação da temperatura superficial dos músculos masseter e temporal anterior durante o apertamento dental voluntário com placas interoclusais maxilares de duas diferentes espessuras

Muscle activity has been studied indirectly through analyses of temperature variation in skin surface temperature on the masticatory muscles. These procedure may be an important tool for clinical evaluation and assessment of the evolution of temporomandibular disorders, as well as monitoring the adopted protocol. Thus, its utilization for identified pathological alterations on blood circulation and/or on metabolic activity in subcutaneous tissues, such as the masticatory muscles, is justified. The aim of this study was to investigate the effect of occlusal splints’ thickness on the variation of surface temperature of the anterior temporal and masseter muscles during rest and clenching. It were analyzed 20 symptomatic subjects (10 males and 10 females) selected through the Research Diagnostic Criteria (RDC) questionnaire. Temperature expressed in degrees Celsius (ºC) was measured on the surface of both muscles measured with the aid of a digital thermometer with an infrared radiation reading system. The surface temperature of the anterior temporal and masseter muscles presented significant reduction during teeth clenching in relation to the mandibular rest position. However, there were no significant differences between conditions with and without occlusal splint or between the different thicknesses of splints analyzed. Masticatory muscles showed a considerable similar behavior for both sides, and no significant distinctions were observed between male and female patients.

Avaliação da biocompatibilidade de implantes de silicone gel em subcutâneo de ratos: estudo histomorfométrico

Objective: Histomorphometric study to evaluate the biological tissue compatibility of silicone implants suitable for plastic surgery. Methods: Thirty Wistar white rats received subcutaneous implants ande the revestiment of silicone gel Silimed, and randomized into six groups of five animals each, according to the type of implanted material and the time of sacrifice. Eight areas of 60.11 mm2 corresponding to the obtained surgical pieces were analyzed, counting mesenchymal cells, eosinophils, and foreign body giant cells, observing an acceptable biocompatibility in all implants, for subsequent statistical analysis by Tukey test. Results: Silicone gel showed inflammation slightly greater than for other groups, with tissue reactions varying from light to moderate, whose result was the formation of a fibrous capsule around the material, recognized by the organism as a foreign body. Conclusion: In general, it is possible to affirm that silicone gel had acceptable levels of biocompatibility, confirmed the rare presence of foreign body giant cells, and when of the rupture, formed a fibrous capsule around the material, separating the material of the organism.

Avaliação microscópica da propriedade biológica e da biocompatibilidade do osso composto e do osso integral de origem bovina

The aim of this study was to evaluate the biological properties and biocompatibility of bovine non-demineralized lyophilized and composite bones implanted in tibiae bone cavities and at the subcutaneous level. Twenty-four rats were used and sacrificed 15 and 45 days later. At the subcutaneous level, after 15 days an inflammatory reaction was seen around biomaterial particles with the presence of giant cells and at 45 days fibrous connective tissue had also developed. No signs of ectopic bone formation were observed at tibiae regions; more bone neoformation was observed at the control group (15 days) with 42.8% of the outer cortex layer against 22.6% at Orthogen and 25% at GenMix groups. At 45 days, correspondent values for bone neoformation were 62.5% at control, 26% at Orthogen, and 35% at GenMix groups, respectively. It can be concluded that both materials tested were biocompatible aiming to bone neoformation by their osteoconductive properties with no ectopic formation sites observed.

Efeito da inibição dos receptores canabinóides CB₁ ou CB₂ durante o período neonatal sobre o dimorfismo sexual esquelético ao longo do desenvolvimento

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Descrição micromorfológica e efeitos do benzo[α]pireno em células hepáticas e sanguíneas das espécies Physalaemus cuvieri e Leptodactylus fuscus (Anura: Leptodactylidae)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

O papel da ciclooxigenase-2 da pressão arterial na lesão renal de ratos submetidos à infusão contínua de angiotensina II

Fundação de Apoio à Pesquisa do Estado de São Paulo (FAPESP)

Fasceíte necrotizante: relato de dois casos

Necrotizing fasciitis is a rare dermatopathy that promotes subcutaneous tissue damage, associated to substantial morbidity and mortality if treatment is not initiated at the beginning of the condition. The objective of the present study is to report the occurrence of two cases of necrotizing fasciitis, one in a miniature female Pinscher and the other one in a female Poodle, both attended at the Veterinary Hospital of FMVZ/Unesp-Botucatu. The animals presented ulcerated, erythematous lesions with secretion and points of necrosis along fascial planes. Bacterial culture was positive for Streptococcus spp. The animals were treated with enrofloxacin, associated to topical cleaning of the lesions with saline solution and triclosan-based soap and rifampicin spray. Both animals presented total remission of lesions after approximately 15 days of treatment. The present report aims to alert veterinary clinicians to the severity of Streptococcus spp infections.

Proporção tecidual da perna de caprinos jovens em função do grupo racial, peso de abate e sexo

To evaluate the effect of breed group, slaughter weight and sex on tissue proportion of the leg and muscle, bone and fat ratio in confined kids, seventy-four goats of both sex were used and divided among breed groups: Alpine (A), ½ Nubian + ½ Alpine (½ ANA), ½ Boer + ½ Alpine (½ BA), ¾ Boer + ¼ Alpine (¾ BA) and ½ Nubian + ¼ Alpine + ¼ Boer, (Three cross - TC), at three slaughter weights (25, 30 and 35 kg). Leg represented 31.01% of half carcass, where 62.29% was total muscle, 21.45% total bone and 8.35% total fat. Alpine animals had higher bone weight than other groups. Male kids had higher muscle and bone proportion, whereas females had higher subcutaneous and intramuscular fat in leg. The percentage of total weight of the muscle, five muscles, adductor muscle, quadriceps muscle and femur were higher in the slaughter weights of 25 and 30 kg.

Efeito imunomodulatório e controle da infecção fúngica do extrato de alho (Allium sativum L.) em modelo murino de esporotricose

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo clínico randomizado e duplo cego comparando dois métodos de escleroterapia para veias reticulares e telangiectasias em membros inferiores

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Propriedades físicas, químicas, antimicrobianas e biológicas de cimentos endodônticos com óxido de cálcio e resina salicilato

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Qualidade da carne de bovinos recriados em pastagens associada a suplementação e terminação a pasto ou no confinamento

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Biocompatibilidade e bioatividade de cimentos à base de silicato tricálcico: estudo in vitro e in vivo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Fatores dietéticos, antropométricos e socioeconômicos associados à sarcopenia em idosos: estudo transversal de base populacional

Pós-graduação em Saúde Coletiva - FMB