Região de Araraquara: elementos para pensar um indicador sobre vocação produtiva grícola

This paper seeks to explore some key elements that are relevant to improve overall productivity including, particularly, the small agricultural enterprises in the so-called "region of Araraquara". Location and infrastructure, among other factors, are of paramount importance; however I endeavor to highlight those, which I consider are the most significant and refer to aspects of cognitive and immaterial labor in the sense that its products are intangible, such as knowledge, communication, interaction, focusing on institutional collaborative activities and productive resistance.

Cálculo e implementação do índice de Desenvolvimento da Gestão Municipal (IDGM) no município de Itabaiana/Se

The scarcity of resources which frequently confronts the State, coupled with demands to provide assistance to a needy population, requires that public administrators formulate efficient and effective policies to pursue its goals. It is fundamental that such policies are based on solid information of existing conditions. As such, the availability of reliable and updated socio-economic indicators is an important tool on which to fundament public policies. The present paper aims to present a Municipal Development Index – Municipal Management Development Index (IDGM) – calculated for the city of Itabaiana/SE, and is divided in two sections. The first discusses the concept of economic development and the evolution of measurement frameworks, with emphasis on the IHD and some of its limitations. The second section describes an estimated IDGM for the city of Itabaiana, as well as its methodology, results, and a brief comparative analysis with four municipalities from the state of São Paulo. Itabaiana’s IDGM reached 849 points (the maximum is 1.000), which infers a good developmental condition.

Análise das matrizes sobre associativismo civil norteadoras da formação de trabalhadores para Ongs

This article presents research that aimed to discuss the theoretical frameworks about civil associativism prescribed by the trainers of non-governmental organizations (NGOs) workers. The requirements for civil associations made by trainers were analyzed based on two data and reference categories, named empirical and analytical. The empirical categories emerged from the data collected by means of interviews with trainers and also examining the documents that guided the course. The analytical categories were constructed from the literature review on the approaches of civil associations, which are: North American Third Sector Approach; Critical Approach to the Third Sector and Social Local Development (DSL in the Portuguese acronym). The study presents indications that could support the development of other research on the topic and, mainly academic knowledge for further development of new training processes for NGO workers.

Modelagem fuzzy aplicada a políticas públicas: proposta de um indice municipal de qualidade ambiental

Pós-graduação em Ciências Ambientais - Sorocaba

O papel da comunicação no processo de transferência de tecnologia da Embrapa para a comunidade indígena Campo Alegre de Boa Vista, RR

Pós-graduação em Comunicação - FAAC

Development of hydrophilic nanocarriers for the charged form of the local anesthetic articaine

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Development and pharmacological evaluation of ropivacaine-2-hydroxypropyl-beta-cyclodextrin inclusion complex

Ropivacaine (RVC) is an enantiomerically pure local anesthetic (LA) largely used in surgical procedures, which presents physico-chemical and therapeutic properties similar to those of bupivacaine (BPV), but associated to less systemic toxicity This study focuses on the development and pharmacological evaluation of a RVC in 2-hydroxypropyl-beta-cyclodextrin (HP-P-CD) inclusion complex. Phase-solubility diagrams allowed the determination of the association constant between RVC and HP-beta-CD (9.46 M-1) and showed an increase on RVC solubility upon complexation. Release kinetics revealed a decrease on RVC release rate and reduced hemolytic effects after complexation. (onset at 3.7 mM and 11.2 mM for RVC and RVCHP-beta-CD, respectively) were observed. Differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and X-ray analysis (X-ray) showed the formation and the morphology of the complex. Nuclear magnetic resonance (NMR) and job-plot experiments afforded data regarding inclusion complex stoichiometry (1:1) and topology. Sciatic nerve blockade studies showed that RVCHP-beta-CD was able to reduce the latency without increasing the duration of motor blockade, but prolonging the duration and intensity of the sensory blockade (p < 0.001) induced by the LA in mice. These results identify the RVCHP-beta-CD complex as an effective novel approach to enhance the pharmacological effects of RVC, presenting it as a promising new anesthetic formulation. (c) 2007 Elsevier B.V All rights reserved.

Encapsulation of Local Anesthetic Bupivacaine in Biodegradable Poly(DL-lactide-co-glycolide) Nanospheres: Factorial Design, Characterization and Cytotoxicity Studies

Local anesthetic agents cause temporary blockade of nerve impulses productiong insensitivity to painful stimuli in the area supplied by that nerve. Bupivacaine (BVC) is an amide-type local anesthetic widely used in surgery and obstetrics for sustained peripheral and central nerve blockade. in this study, we prepared and characterized nanosphere formulations containing BVC. To achieve these goals, BVC loaded poly(DL-lactide-co-glycolide) (PLGA) nanospheres (NS) were prepared by nanopreciptation and characterized with regard to size distribution, drug loading and cytotoxicity assays. The 2(3-1) factorial experimental design was used to study the influence of three different independent variables on nanoparticle drug loading. BVC was assayed by HPLC, the particle size and zeta potential were determined by dynamic light scattering. BVC was determined using a combined ultrafiltration-centrifugation technique. The results of optimized formulations showed a narrow size distribution with a polydispersivity of 0.05%, an average diameter of 236.7 +/- 2.6 nm and the zeta potential -2.93 +/- 1,10 mV. In toxicity studies with fibroblast 3T3 cells, BVC loaded-PLGA-NS increased cell viability, in comparison with the effect produced by free BVC. In this way, BVC-loaded PLGA-NS decreased BVC toxicity. The development of BVC formulations in carriers such as nanospheres could offer the possibility of controlling drug delivery in biological systems, prolonging the anesthetic effect and reducing toxicity.

Polymeric alginate nanoparticles containing the local anesthetic bupivacaine

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Traffic soil compaction of an oxisol related to soybean development and yield

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Development of 22 Polymorphic Microsatellite Loci for the Critically Endangered Morato's Digger Toad, Proceratophrys moratoi

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudo do mercado de trabalho em Arranjo Produtivo Local (APL): território e produção cerâmica em Santa Gertrudes/SP

No presente artigo, sob a perspectiva de que toda aglomeração produtiva está associada a um respectivo mercado de trabalho local, são analisadas as principais características do mercado de trabalho inerente à territorialidade da indústria de revestimentos cerâmicos da região de Santa Gertrudes/SP. No contexto de profundas modificações na atividade industrial e no mundo do trabalho que conduzem a novos formatos espaciais das relações econômicas, são discutidos no texto a pertinência da noção de mercado de trabalho local à luz da atual ênfase dada aos aglomerados territoriais de pequenas e médias empresas - chamados de APLs (Arranjos Produtivos Locais)- a partir de seu potencial gerador de competitividade e desenvolvimento territorial.

Effect of substrata on the development of stem cuttings of Lippia alba (Mill.) NEBR. - Limonene-carvone chemotype

Studies were conducted to show the effect of different substrata on the development of stem cuttings of Lippia alba made of limonene-carvone chemotype. The experiment was done in the College of Agronomical Sciences, UNESP, Botucatu, SP, Brazil in 2000. The cuttings were planted in polystyrene trays consisting of 72 cells. The cuttings had about 0.20 m of length and were put in the following substrata:Fine sand (T1), commercial substratum (T2), carbonised rice peel and local soil (T3), local soil, cow manure and carbonised rice peel (T4), vermiculite (T5), and carbonised rice peel (T6). After 40 days the development of stem cuttings were evaluated. High rate of rooting of stem cuttings was verified, with average of 95 10 and no significant difference between the treatments. In relation to dry mass of aerial parts and dry mass of roots, significant differences were found. For dry mass production of aerial parts the commercial substratum (T2) and the local soil, cow manure, carbonised rice peel (T4) were optimal. For mass of roots the local soil, cow manure, carbonised rice peel (T4) proved to be the best.

Initial Development and Characterization of PLGA Nanospheres Containing Ropivacaine

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats

Purpose: Ultrasound (US) therapy is an elect rot hermotherapeutic modality that uses US energy to provoke physical and chemical alterations. US therapy has been widely used in physical therapy. However in clinical practice, it is contra-indicated in cancer patients due to the possibility of exacerbating tumor growth.Methods: Sixty-eight female Sprague-Dawley rats bred in UNIFAE vivarium were studied. At 50 days of age, 7, 12-dimetylbenz(a)anthracene (7, 12-DMBA) was administered to 35 rats by gastric gavage to induce mammary cancer After 90 days the mammary glands of the rats belonging to the group with mammary cancer induction and stimulated by US were removed. Animals received either continuous or pulsed US. US waves were generated at a frequency of 1 MHz during 10 days, with an intensity dose of 0.5 W in the continuous group, and 0.9 W (duty cycle: 20%) in the pulsed group.Results: Among the rats treated with continuous US, 44.4% developed local recurrence, while among the rats treated with pulsed US, 22.2% had local tumor recurrence (p < 0.05). No evidence of distant metastases was shown in any of the rats studied.Conclusion: The use ofcontinuous and pulsed therapeutic US promoted the development of local recurrence of mammary cancer in female Sprague-Dawley rats in the postoperative period.