Progression of articular and extraarticular damage in oligoarticular juvenile idiopathic arthritis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudo de simulação de modelos lineares mistos com distribuição normal contaminada no melhoramento genético animal

Objetivou-se com esse trabalho comparar estimativas de componentes de variâncias obtidas por meio de modelos lineares mistos Gaussianos e Robustos, via Amostrador de Gibbs, em dados simulados. Foram simulados 50 arquivos de dados com 1.000 animais cada um, distribuídos em cinco gerações, em dois níveis de efeito fixo e três valores fenotípicos distintos para uma característica hipotética, com diferentes níveis de contaminação. Exceto para os dados sem contaminação, quando os modelos foram iguais, o modelo Robusto apresentou melhores estimativas da variância residual. As estimativas de herdabilidade foram semelhantes em todos os modelos, mas as análises de regressão mostraram que os valores genéticos preditos com uso do modelo Robusto foram mais próximos dos valores genéticos verdadeiros. Esses resultados sugerem que o modelo linear normal contaminado oferece uma alternativa flexível para estimação robusta em melhoramento genético animal.

The effect of implant design on insertion torque and immediate micromotion

Objectives: To evaluate the effect of insertion torque on micromotion to a lateral force in three different implant designs. Material and methods: Thirty-six implants with identical thread design, but different cutting groove design were divided in three groups: (1) non-fluted (no cutting groove, solid screw-form); (2) fluted (901 cut at the apex, tap design); and (3) Blossomt (Patent pending) (non-fluted with engineered trimmed thread design). The implants were screwed into polyurethane foam blocks and the insertion torque was recorded after each turn of 901 by a digital torque gauge. Controlled lateral loads of 10N followed by increments of 5 up to 100N were sequentially applied by a digital force gauge on a titanium abutment. Statistical comparison was performed with two-way mixed model ANOVA that evaluated implant design group, linear effects of turns and displacement loads, and their interaction. Results: While insertion torque increased as a function of number of turns for each design, the slope and final values increased (Po0.001) progressively from the Blossomt to the fluted to the non-fluted design (M +/- standard deviation [SD] = 64.1 +/- 26.8, 139.4 +/- 17.2, and 205.23 +/- 24.3 Ncm, respectively). While a linear relationship between horizontal displacement and lateral force was observed for each design, the slope and maximal displacement increased (Po0.001) progressively from the Blossomt to the fluted to the non-fluted design (M +/- SD 530 +/- 57.7, 585.9 +/- 82.4, and 782.33 +/- 269.4 mm, respectively). There was negligible to moderate levels of association between insertion torque and lateral displacement in the Blossomt, fluted and non-fluted design groups, respectively. Conclusion: Insertion torque was reduced in implant macrodesigns that incorporated cutting edges, and lesser insertion torque was generally associated with decreased micromovement. However, insertion torque and micromotion were unrelated within implant designs, particularly for those designs showing the least insertion torque.

Uma abordagem fuzzy para a avaliação técnico-econômica de redes de acesso

O surgimento de novas tecnologias e serviços vem impondo mudanças substanciais ao tradicional sistema de telecomunicações. Múltiplas possibilidades de evolução do sistema fazem da etapa de planejamento um procedimento não só desejável como necessário, principalmente num ambiente de competitividade. A utilização de metodologias abrangentes e flexíveis que possam auxiliar no processo de decisão, fundadas em modelos de otimização, parece um caminho inevitável. Este artigo propõe um modelo de programação linear inteiro misto para ajudar no planejamento estratégico de sistemas de telecomunicações, e em particular da rede de acesso. Os principais componentes de custo e receita são identificados e o modelo é desenvolvido para determinar a configuração da rede (serviços, tecnologias, etc) que maximize a receita esperada pelo operador do sistema. O conceito de números fuzzy é adotado para avaliar o risco técnico-econômico em situações de imprecisão nos dados de demanda. Resultados de experimentos computacionais são apresentados e discutidos.

ANÁLISE DE REGRESSÃO em EXPERIMENTOS em PARCELAS SUBDIVIDIDAS COM DADOS NÃO-BALANCEADOS: UMA SOLUÇÃO NA LINGUAGEM GLIM

São estabelecidas as matrizes necessárias para a realização da análise de variância de experimentos em parcelas subdivididas, com dados não-balanceados e balanceados, quando os tratamentos aplicados às parcelas e os tratamentos aplicados às subparcelas são ambos fatores quantitativos, usando a teoria de modelos lineares e de modelos lineares generalizados. Foi desenvolvido um programa computacional, na linguagem GLIM, para a realização da análise.

Narrativas orais de crianças com desenvolvimento típico de linguagem

TEMA: desenvolvimento da narrativa oral. OBJETIVO: verificar o tempo de narrativa e de pausa, o número de palavras e de intervenções do interlocutor em narrativas orais de crianças com desenvolvimento típico. MÉTODO: participaram do estudo 31 crianças divididas em quatro grupos etários: GI (3:1 a 4:0 anos), GII (4:1 a 5:0 anos), GIII (5:1 a 6:0 anos) e GIV (6:1 a 7:0 anos). Amostras de narrativa espontânea e narrativa com livro sem palavras foram coletadas em vídeo, transcritas e analisadas estatisticamente por meio de teste exato de Fisher (não-paramétrico) e modelo de regressão linear com efeitos mistos. RESULTADOS: os valores de tempo de pausa, tempo de narrativa, e o número de palavras no contexto de livro foram significativamente maiores em relação à narrativa espontânea (p-valor < 0,01). Quanto ao número de intervenções, houve correlação (p-valor = 0,03) entre idade e intervenção no contexto de livro com diminuição da intervenção na media que aumentou a idade. CONCLUSÃO: as crianças apresentaram uma narrativa mais extensa no contexto de relato com livro sem palavras em relação ao contexto de narrativa espontânea, porém, sem diferenças significativas entre as idades. O estudo permitiu ainda concluir que a participação do interlocutor faz-se menos necessária conforme aumenta a idade do narrador.

Optimized Allocation of Control and Protective Devices in Electric Distribution Systems

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Droplet formation in cold asymmetric nuclear matter in the quark-meson-coupling model

The quark-meson-coupling model is used to study droplet formation from the liquid-gas phase transition in cold asymmetric nuclear matter. The critical density and proton fraction for the phase transition are determined in the mean field approximation. Droplet properties are calculated in the Thomas-Fermi approximation. The electromagnetic field is explicitly included and its effects on droplet properties are studied. The results are compared with the ones obtained with the NL1 parametrization of the non-linear Walecka model. © 2000 Elsevier Science B.V.

Design of microirrigation systems in sloping lands using linear programming

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Environmental factors influencing foraging activity in the social wasp Polybia paulista (Hymenoptera: Vespidae: Epiponini)

Foraging behavior in social wasps is important in the development of the colony and reflects an important ecological interaction between the colony and the environment. Although the social traits of the colony play a role in the foraging activities, the conditions that establish the space and time limits are mainly physical. Here, we evaluate colonies of Polybia paulista throughout one year in order to verify the foraging activities and the items collected, as well as the importance of temperature, relative humidity, and solar radiation on motivating foraging. Collection of liquids was always higher than that of solids; preys were collected all year long, and nests showed two annual episodic expansions. The linear mixed effects (LME) model used to analyze which weather factors influence the foraging showed temperature as the most influencing factor on the collection of materials. © 2011 Naila Cristina de Souza Canevazzi and Fernando Barbosa Noll.

Linear and Poisson models for genetic evaluation of tick resistance in cross-bred Hereford x Nellore cattle

Cattle resistance to ticks is measured by the number of ticks infesting the animal. The model used for the genetic analysis of cattle resistance to ticks frequently requires logarithmic transformation of the observations. The objective of this study was to evaluate the predictive ability and goodness of fit of different models for the analysis of this trait in cross-bred Hereford x Nellore cattle. Three models were tested: a linear model using logarithmic transformation of the observations (MLOG); a linear model without transformation of the observations (MLIN); and a generalized linear Poisson model with residual term (MPOI). All models included the classificatory effects of contemporary group and genetic group and the covariates age of animal at the time of recording and individual heterozygosis, as well as additive genetic effects as random effects. Heritability estimates were 0.08 ± 0.02, 0.10 ± 0.02 and 0.14 ± 0.04 for MLIN, MLOG and MPOI models, respectively. The model fit quality, verified by deviance information criterion (DIC) and residual mean square, indicated fit superiority of MPOI model. The predictive ability of the models was compared by validation test in independent sample. The MPOI model was slightly superior in terms of goodness of fit and predictive ability, whereas the correlations between observed and predicted tick counts were practically the same for all models. A higher rank correlation between breeding values was observed between models MLOG and MPOI. Poisson model can be used for the selection of tick-resistant animals. © 2013 Blackwell Verlag GmbH.

Genetic parameter estimates and principal component analysis of breeding values of reproduction and growth traits in female Canchim cattle

Phenotypic data from female Canchim beef cattle were used to obtain estimates of genetic parameters for reproduction and growth traits using a linear animal mixed model. In addition, relationships among animal estimated breeding values (EBVs) for these traits were explored using principal component analysis. The traits studied in female Canchim cattle were age at first calving (AFC), age at second calving (ASC), calving interval (CI), and bodyweight at 420 days of age (BW420). The heritability estimates for AFC, ASC, CI and BW420 were 0.03±0.01, 0.07±0.01, 0.06±0.02, and 0.24±0.02, respectively. The genetic correlations for AFC with ASC, AFC with CI, AFC with BW420, ASC with CI, ASC with BW420, and CI with BW420 were 0.87±0.07, 0.23±0.02, -0.15±0.01, 0.67±0.13, -0.07±0.13, and 0.02±0.14, respectively. Standardised EBVs for AFC, ASC and CI exhibited a high association with the first principal component, whereas the standardised EBV for BW420 was closely associated with the second principal component. The heritability estimates for AFC, ASC and CI suggest that these traits would respond slowly to selection. However, selection response could be enhanced by constructing selection indices based on the principal components. © CSIRO 2013.

Modelos matemáticos para problemas de dimensionamento de lotes com restrições de capacidade e custos de transporte

In this paper, capacitated lot sizing problems in which the classical lot sizing decisions are made considering the transportation costs of the manufactured products were studied. These costs are related to the necessary number of pallets or trucks to pack and/or transport the products from the factory to the warehouse. Three extensions of a mixed integer linear programming model from the literature are considered, representing general cases that are commonly found in companies. These models are tested and evaluated using an optimization package, and a Lagrangian heuristic was developed for one of the extensions proposed.

Influência do modelo de análise estatística e da forma das parcelas experimentais na seleção de clones de Eucalyptus spp

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estimativas de parâmetros genéticos para escores visuais e características de crescimento na raça Nelore

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)