Remodelamento parenquimatoso pulmonar em dois modelos experimentais de fibrose

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Biotechnology of polyketides: new breath of life for the novel antibiotic genetic pathways discovery through metagenomics

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Nanometer Scale Titanium Surface Texturing Are Detected by Signaling Pathways Involving Transient FAK and Src Activations

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

From west to east: Environmental influences on the rate and pathways of Polynesian colonization

The prime movers behind the prehistoric colonization of Remote Oceania, and in particular the large c. 2000-year temporal gap (i.e. long pause') seen between West and East Polynesia, has long been major point of interest in the Pacific. To address these events and the processes that may have led to the known chronological disparity of these diasporas, we present results from two different, but equally powerful, analytical tools which are used to examine Polynesian seafaring capabilities and trajectories. The first is a statistical model known as Seascape, which simulates voyages, while the second uses ease of eastward travel estimates based on land distribution and wind pattern analysis. These analyses were done with the goal of determining the potential role of environmental factors in the colonization process, particularly as they relate to the long pause. We show that the eastern boundary of West Polynesia, the limit of the initial colonization pulse, is marked by a discontinuity in land distribution, where the distances travelers would have to cross in order to reach islands further to the east become significantly larger. At the same time, in West Polynesia, the frequency and intensity of winds favorable to eastward displacement decrease continuously from west to east. As far as winds are concerned, eastward travel in West Polynesia is favored in the northern and southern areas and much more difficult across the central portion. Favorable winds have a clear seasonality, and eastward displacement along the northern area is much easier under El Nino conditions. Voyaging simulations show that intentional eastward voyages departing from Tonga and Samoa, when undertaken with vessels capable of sailing efficiently against the wind, afford a viable route toward several island groups in East Polynesia, with trips starting in Samoa having a higher probability of success.

Molecular properties of the PCO radical: heat of formation and the isomerization pathways

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Population Parameters Based on Known Pedigree Records from Brazilian Jaffarabadi Buffaloes

The objective of this study was to evaluate the effective number of founders and ancestors, generation intervals and completeness of pedigree in Jaffarabadi breed buffaloes raised in Brazil. Pedigree records of 1,272 animals born from 1966 were used. The parameters were estimated using ENDOG, computational population genetic software. The obtained value for completeness of pedigree was 99.5, 50.9, and 20.5 for, the first, second and third generations, respectively. Generation interval estimates expressed in years and considering different pathways were 12.28 +/- 6.90 (sire-son), 11.55 +/- 6.07 (sire-daughter), 8.20 +/- 2.63 (dam-son) and 8.794 +/-.33 (dam-daughter). The overall average generation interval was 10.17 +/- 5.43 years. The number of founders, equivalent founders and ancestor animals that contributed for the genetic diversity in the reference population (1059) were 136, 130 and 134, respectively. Effective number of founder (f(e)=8) and ancestors (f(a)=7) were small, and the calculated expected inbreeding increase per generation was 4.99%. Four ancestors explained 50% of the genetic variability in the population and the major ancestor contributed with approximately 33% of the total population genetic variation. The genetic diversity within the current population is low as a consequence of a reduced number of ancestors.

Effect of menthol in experimentally induced ulcers: Pathways of gastroprotection

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Signaling Pathways Activation by Primary Endodontic Infectious Contents and Production of Inflammatory Mediators

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Acerola (Malpighia emarginata DC.) juice intake protects against alterations to proteins involved in inflammatory and lipolysis pathways in the adipose tissue of obese mice fed a cafeteria diet

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Effects of Physical Exercise on the P38MAPK/REDD1/14-3-3 Pathways in the Myocardium of Diet-Induced Obesity Rats

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Novel bioassay for the discovery of inhibitors of the 2-C-Methyl-D-erythritol 4-Phosphate (MEP) and terpenoid pathways leading to carotenoid biosynthesis

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Endothelial AT(1) and AT(2) pathways in aortic responses to angiotensin II after stress and ethanol consumption in rats

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Análise do esforço amostral para ecologia comportamental: onças pardas como exemplo

Pós-graduação em Biociências - FCLAS

Melatonin attenuates the TLR4-mediated inflammatory response through MyD88-and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Growth hormone influences atrophy pathways in skeletal muscle of heart failure rats

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)