48 resultados para Research Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistry::Polymer chemistry


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Pós-graduação em Geociências e Meio Ambiente - IGCE

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Pós-graduação em História - FCLAS

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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The discussions waged by several authors in the field of philosophy of science about scientificity and scientific work often fall to the shock of Sciences, who had long substantiate their studies from the perspective of Natural Sciences. Fact that the man away from research, transforming it into a simple object of study. Among these questions, it is necessary to think in a very scientificity of the humanities, which considers the various types of knowledge that makes up the formation of the individual. In this way, approaching the experience, treated by Agambem Benjamin Larrosa and the educational research with children presents itself as a chance to rethink the current paradigm of Sciences. This gives rise to the objective of this work reflect, based on a research conducted with children and imagetic production, the idea of 'research and its relation to the concept of experience'. We will take as its starting point the elaborations on this concept as presented by Giorgio Agamben. We are assuming that the images of that research, are configured as research papers or research and, in this sense, the research is defined as a documentary research

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Pós-graduação em Educação Escolar - FCLAR

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Natural killer (NK) cell activity was evaluated after the initiation and promotion steps in a medium-term multi-organ bioassay for carcinogenesis. NK cell activity was assessed in vitro by Cr51 release assay at the 4th and 30th weeks of the experiment. Male Wistar rats were sequentially initiated with N-diethylnitrosamine (DEN i.p.), N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN drinking water), N-methyl-N-nitrosourea (MNU i.p.), dihydroxy-di-N-propylnitrosamine (DHPN drinking water) and N,N'-dimethylhydrazine (DMH s.c.) at subcarcinogenic doses for 4 weeks (DMBDD initiation). One group was evaluated at the 4th week and the other was maintained without any further treatment until the 30th week. Two initiated groups were exposed through the diet to 2-acetylaminofluorene (2-AAF) or phenobarbital (PB), from the 6th until the 30th week. Five additional groups were studied to evaluate the effects of each initiator on NK activity. All groups submitted to initiation only, initiation plus promotion, or promotion only, developed significantly more preneoplastic lesions than the untreated control group. The main target organs for tumor development in the initiated animals were the liver and the colon, irrespective of treatment with 2-AAF or PB. NK cell activity was not affected by exposure to genotoxic carcinogens after initiation, at the 4th week. Treatments only with PB or 2-AAF did not change NK cell activity. However, decreased NK cell activity was registered in the group only initiated with DMBDD and in the group given DMBDD+2-AAF. This late depression of NK cell activity at the 30th week could be related to the production of suppressing molecules by the tumor cells.

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Pós-graduação em Saúde Coletiva - FMB

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Pós-graduação em Educação para a Ciência - FC

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)