Exploring the multifactorial nature of autism through computational systems biology: Calcium and the Rho GTPase RAC1 under the spotlight

Autism is a neurodevelopmental disorder characterized by impaired social interaction and communication accompanied with repetitive behavioral patterns and unusual stereotyped interests. Autism is considered a highly heterogeneous disorder with diverse putative causes and associated factors giving rise to variable ranges of symptomatology. Incidence seems to be increasing with time, while the underlying pathophysiological mechanisms remain virtually uncharacterized (or unknown). By systematic review of the literature and a systems biology approach, our aims were to examine the multifactorial nature of autism with its broad range of severity, to ascertain the predominant biological processes, cellular components, and molecular functions integral to the disorder, and finally, to elucidate the most central contributions (genetic and/or environmental) in silico. With this goal, we developed an integrative network model for gene-environment interactions (GENVI model) where calcium (Ca2+) was shown to be its most relevant node. Moreover, considering the present data from our systems biology approach together with the results from the differential gene expression analysis of cerebellar samples from autistic patients, we believe that RAC1, in particular, and the RHO family of GTPases, in general, could play a critical role in the neuropathological events associated with autism. © 2013 Springer Science+Business Media New York.

Study of Brazilian commercial Oriented Strand Board panels using stress wave

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Proteome and phosphoproteome of Africanized and European honeybee venoms

Honey bee venom toxins trigger immunological, physiological, and neurological responses within victims. The high occurrence of bee attacks involving potentially fatal toxic and allergic reactions in humans and the prospect of developing novel pharmaceuticals make honey bee venom an attractive target for proteomic studies. Using label-free quantification, we compared the proteome and phosphoproteome of the venom of Africanized honeybees with that of two European subspecies, namely Apis mellifera ligustica and A. m. carnica. From the total of 51 proteins, 42 were common to all three subspecies. Remarkably, the toxins melittin and icarapin were phosphorylated. In all venoms, icarapin was phosphorylated at the 205Ser residue, which is located in close proximity to its known antigenic site. Melittin, the major toxin of honeybee venoms, was phosphorylated in all venoms at the 10Thr and 18Ser residues. 18Ser phosphorylated melittin-the major of its two phosphorylated forms-was less toxic compared to the native peptide. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Doença de Parkinson: deslizamentos do dizer marcados por hesitações em contexto fonético-fonológico recorrente

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

O processo de individualização do sujeito no discurso publicitário

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Características dos enunciados dispersos de uma criança com diagnóstico fonoaudiológico de distúrbio de linguagem

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O político, o jurídico e o assistencial no discurso administrativo sobre a mulher

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Análise discursiva de dicionários de língua portuguesa

Pós-graduação em Estudos Linguísticos - IBILCE

Análise discursiva de dicionários bilíngues Português-Espanhol

Pós-graduação em Estudos Linguísticos - IBILCE

A realidade-ficção do discurso televisivo

Pós-graduação em Estudos Linguísticos - IBILCE

A obra lexicográfica de Francisco da Silveira Bueno

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação da tromboflebite jugular experimental em equinos tratados com heparina

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A Intertextualidade geradora de sentido no gênero desenho animado de núcleo familiar Os Simpsons

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Carta capital e Veja: a cobertura do discurso ecológico-político do Partido Verde na eleição presidencial de 2010

Pós-graduação em Comunicação - FAAC

Campanha Fome Zero: a construção do sentido na mídia televisiva

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)