The Genome of Anopheles darlingi, the main neotropical malaria vector

Anopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors ∼100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vectorhuman and vectorparasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at www.labinfo.lncc.br/index.php/anopheles- darlingi. © 2013 The Author(s).

Fraturas de rádio e ulna em cães no período de janeiro de 2001 a dezembro de 2011

Pós-graduação em Cirurgia Veterinária - FCAV

Variabilidade genética de caracteres relacionados ao enraizamento de estacas de progênies e clones de guanandi (Calophyllum brasiliense Cambess

Pós-graduação em Ciência Florestal - FCA

Estudo da influência da flexibilidade dos discos nas rotações críticas de rotores

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Dynamical evolution of V-type asteroids in the central main belt

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Entoepidemiology of Chagas disease in northwest Sao Paulo and cytogenetic analysis of its main vector, Triatoma sordida (Hemiptera: Triatominae)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Genetic Variability and Geographical Diversity of the Main Chagas' Disease Vector Panstrongylus megistus (Hemiptera: Triatominae) in Brazil Based on Ribosomal DNA Intergenic Sequences

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A study of the main oxidation products of natural pyrite by voltammetric and photoelectrochemical responses

(Photo)electrochemical experiments on pyrite electrodes in acetic acid-acetate buffer (pH = 4.5) are conducted to clarify the main oxidation reactions and the nature of the products. Electrochemical reactions in the -0.40 to 1.25 V (SHE) potential range are studied, and the production of iron (III) polysulfide from anodically formed iron oxides and polysulfides is discussed. Charges experimentally obtained are considered for the estimation of the most likely stoichiometry of the metallic polysulfide. The photoselectivity of the pyrite corrosion process indicates that the oxidation reactions of Fe2+ and S-2(2-) an not consecutive. The changes in stoichiometry and/or annihilation of crystalline structure defects are responsible for the observed photosensitivity of pyrite. A description of light effects on the interfacial behaviour and stability of pyrite is presented in terms of conduction and valence band energies, and thermodynamic potentials. (C) 2001 Elsevier Science B.V. All rights reserved.

Dynamical evolution of V-type photometric candidates in the outer main belt

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

The Relationship between Authors and Main Thematic Categories in the Field of Knowledge Organization: A Bibliometric Approach

This is a study about the relationships between authors and the main thematic categories in the papers published in the last five International ISKO Conferences, held between 2002 and 2010. The aim is to map the domain as ISKO conferences are considered the most representative forum in the field. The published papers are considered to indicate the relationships between authors and themes. The Classification Scheme for Knowledge Organization Error! Bookmark not defined Literature (CSKOL) was used to categorize the papers. The theoretical and methodological foundations of the study can be found in the concept of domain analysis proposed by Hjorland. The analysis of the papers (n=146) led to the identification of the most productive authors, the networks representing the relationships between the authors as also the categories that constitute the primary areas of research.

Um Estudo de caso sobre a fabricação de engrenagens

Human evolution has always been linked to personal or group needs. This statement is based on observations of the day to day. With time, we can now choose from among many excellent techniques and materials that can be employed in the construction of this part of the machinery so important to the functionality of machines and equipment. When we look at a machine, we see that this is usually designed by combining a set of pre-determined in your project. Among the many pieces that we can highlight one of them is of fundamental importance, the gear. Gears are an example of the mechanical devices used by the older man, and are currently the most important components in the transmission technique. This is responsible for transmitting rotary motion from one shaft to another. Gears are one of the best among the various means available for the transmission of motion. Gears are the most important components of modern technique of transmission. The main purpose of a transmission gear is precisely transmit torque and speed. The requirements have increased significantly due to pollution and energy conservation. Nowadays, gear transmissions are required to transmit high strength through all his life together with the high demand on performance and sound properties. An optimal design for the gear you need a set of the most modern fabrication machines and cutting tools. In the following work is studied on the manufacture of gears, making the monitoring of a case study of the try out the installation of a gear grinding machine

Radiographic evaluation of root canal cleaning, main and laterals, using different methods of final irrigation

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Organisation and tyrosine hydroxylase and calretinin immunoreactivity in the main olfactory bulb of paca (cuniculus paca): a large caviomorph rodent

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A kinetic study of the main guaco metabolites using syrup formulation and the identification of an alternative route of coumarin metabolism in humans

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Fluorescent antibody test, quantitative polymerase chain reaction pattern and clinical aspects of rabies virus strains isolated from main reservoirs in Brazil

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)