67 resultados para Genomic data integration


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This paper presents a multi-agent architecture that was designed to develop processes supervision and control systems, with the main objective to automate tasks that are repetitive and stressful, and error prone when performed by humans. A set of agents were identified, based on the study of a number of applications found in the literature, that use the approach of multi-agent systems for data integration and process monitoring to faults detection and diagnosis, these agents are used as basis of the proposed multi-agent architecture. A prototype system for the analysis of abnormalities during oil wells drilling was developed.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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This study is based on the mapping of occurrences associated with social vulnerability and natural risks, which refer to the resilience of populations and territories, regarding natural hazards associated with the functioning of natural systems (eg, earthquakes, flood, mass movements). According to UNISDR (2014), the state of São Paulo is a reference in working with Urban Resilience and Disaster in the Resilient Cities Campaign (2014), considering the high investment in Risk Areas Mapping and Public Education Campaigns implemented by the Civil Defense. Thus, this study aims to mapping the occurrence of events related to Tree Falls, Erosion, Landslides, Irregular Housing, Rocky Blocks Falls, Wall Falls, Unroofing and Irregular Construction, attended by the Civil Defense in the city of Santos, São Paulo State, from 2011 to 2014. Thereafter, correlated analyzes to the Environmental Vulnerabilities were generated. The Environmental Vulnerability databases used in this dissertation compose the results of the CNPQ Project - Environmental Vulnerability Mapping of the State of Sao Paulo - Brazil: a methodological contribution of Freitas (2013) and Bortolettoet al (2014), with information collected from the 2010 Census (IBGE, 2010), on a census sectors scale. The adopted methodological procedure involves document analysis followed by data integration in Geographic Information System, through algorithms analysis and mapscrossing.The results obtained in Maps of Social and Environmental Vulnerability Occurrences presented areas of High or Very High Vulnerability. The main variables obtained with such characteristics are Irregular Housing, Landslides and Rocky Blocks Falls, which was associated with hilly terrain formations, with slopes above 30%. To the areas of Medium, Low and Very Low Vulnerability were associated the variables Tree Falls, Wall Falls, Erosion, Unroofing and Irregular Construction, which are spatially distributed without an...

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Pós-graduação em Ciência da Computação - IBILCE

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The objectives of this study were to evaluate land use and occupation of Permanent Preservation Areas (PPA) as well as its use conflicts by TM (Thematic Mapper) image of the 2010 Landsat-5 satellite, according to the Forest Code. For that purpose, Geographic Information Systems in the Ribeirão Paraíso watershed, São Manuel, SP were used. The combination of Remote Sensing and Geographic Information System technologies allowed representation of spatial distribution of the landscape and data integration in the diagnosis of geographic interest. The 2010 mapping showed 12 use categories, and the sugar cane crop had the largest land occupation, 48.25% of the area. The areas of permanent preservation amounted to 925.74 ha, which is an ideal value based on the Brazilian legislation. Mapping of land use conflicts showed intensive anthropic actions going 80.13% forward on PPAs, with only 19.87% remaining forests, which highlights their negative impact and illegal situations in these areas.

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The use of geographic information systems (GIS), combined with advanced analysis technique, enables the standardization and data integration, which are usually from different sources, allowing you to conduct a joint evaluation of the same, providing more efficiency and reliability in the decision-making process to promote the adequacy of land use. This study aimed to analyze the priority areas of the basin agricultural use of the Capivara River, Botucatu, SP, through multicriterial analysis, aiming at conservation of water resources. The results showed that the Geographic Information System Idrisi Selva combined with advanced analysis technique and the weighted linear combination method proved to be an effective tool in the combination of different criteria, allowing the determination of the adequacy of agricultural land use less subjective way. Environmental criteria were shown to be suitable for the combination and multi-criteria analysis, allowing the preparation of the statement of suitability classes for agricultural use and can be useful for regional planning and decision-making by public bodies and environmental agents because the method takes into account the rational use of land and allowing the conservation of hydrics resources.

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This study used a multi-analytical approach based on traditional microbiological methods for cultivation and isolation of heterotrophic bacteria in the laboratory associated with the molecular identification of the isolates and physicochemical analysis of environmental samples. The model chosen for data integration was supported by knowledge from computational neuroscience, and composed by three modules: (i) microbiological parameters, contemplating taxonomic data obtained from the partial sequencing of the 16S rRNA gene from 80 colonies of heterotrophic bacteria isolated by plating method in PCA media. For bacterial colonies isolation were used water samples from Atibaia and Jaguarí rivers collected at the site of water captation for use in effluent treatment, upstream from the entrance of treated effluent from the Paulínia refinery (REPLAN/Petrobras) located in the Paulínia-SP municipality, from the output of the biological treatment plant with stabilization pond and from the raw refinery wastewater; (ii) chemical parameters, ending measures of dissolved oxygen (DO), chemical oxygen demand (COD), biochemical oxygen demand (BOD), chloride, acidity CaCO3, alkalinity, ammonia, nitrite, nitrate, dissolved ions, sulfides, oils and greases; and (iii) physical parameters, comprising the pH determination, conductivity, temperature, transparency, settleable solids, suspended and soluble solids, volatile material, remaining fixing material (RFM), apparent color and turbidity. The results revealed interesting theoretical relationships involving two families of bacteria (Carnobacteriaceae and Aeromonadaceae). Carnobacteriaceae revealed positive theoretical relationships with COD, BOD, nitrate, chloride, temperature, conductivity and apparent color and negative theoretical relationships with the OD. Positive theoretical relationships were shown between Aeromonadaceae and OD and nitrate, while this bacterial family showed negative theoretical...

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Pós-graduação em Geografia - IGCE

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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GPS precise point positioning (PPP) can provide high precision 3-D coordinates. Combined pseudorange and carrier phase observables, precise ephemeris and satellite clock corrections, together with data from dual frequency receivers, are the key factors for providing such levels of precision (few centimeters). In general, results obtained from PPP are referenced to an arbitrary reference frame, realized from a previous free network adjustment, in which satellite state vectors, station coordinates and other biases are estimated together. In order to obtain consistent results, the coordinates have to be transformed to the relevant reference frame and the appropriate daily transformation parameters must be available. Furthermore, the coordinates have to be mapped to a chosen reference epoch. If a velocity field is not available, an appropriated model, such as NNR-NUVEL-IA, has to be used. The quality of the results provided by this approach was evaluated using data from the Brazilian Network for Continuous Monitoring of the Global Positioning System (RBMC), which was processed using GIPSY-OASIS 11 software. The results obtained were compared to SIRGAS 1995.4 and ITRF2000, and reached precision better than 2cm. A description of the fundamentals of the PPP approach and its application in the integration of regional GPS networks with ITRF is the main purpose of this paper.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Genetic variation in the transcription factor interferon regulatory factor 6 (IRF6) causes and contributes risk for oral clefting disorders. We hypothesized that genes regulated by IRF6 are also involved in oral clefting disorders. We used five criteria to identify potential IRF6 target genes; differential gene expression in skin taken from wild-type and Irf6-deficient murine embryos, localization to the Van der Woude syndrome 2 (VWS2) locus at 1p36-1p32, overlapping expression with Irf6, presence of a conserved predicted-binding site in the promoter region, and a mutant murine phenotype that was similar to the Irf6 mutant mouse. Previously, we observed altered expression for 573 genes; 13 were located in the murine region syntenic to the VWS2 locus. Two of these genes, Wdr65 and Stratifin, met 4 of 5 criteria. Wdr65 was a novel gene that encoded a predicted protein of 1,250 amino acids with two WD domains. As potential targets for Irf6 regulation, we hypothesized that disease-causing mutations will be found in WDR65 and Stratifin in individuals with VWS or VWS-like syndromes. We identified a potentially etiologic missense mutation in WDR65 in a person with VWS who does not have an exonic mutation in IRF6. The expression and mutation data were consistent with the hypothesis that WDR65 was a novel gene involved in oral clefting. (C) 2011 Wiley-Liss, Inc.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)