Frequency of the HFE C282Y and H63D polymorphisms in Brazilian malaria patients and blood donors from the Amazon region

Malaria is an endemic parasitosis and its causitive agent, Plasmodium, has a metabolism linked to iron supply. HFE is a gene with the polymorphisms C282Y and H63D, which are associated with a progressive iron accumulation in the organism leading to a disease called hereditary hemochromatosis. The aim of the present study was to determine the allelic and genotypic frequencies of the HFE gene polymorphisms in malaria patients and blood donors from the Brazilian Amazon region. We screened 400 blood donors and 400 malaria patients for the HFE C282Y and H63D polymorphisms from four states of the Brazilian Amazon region by polymerase chain reaction and restriction fragment length polymorphism analysis. We did not find any C282Y homozygous individuals, and the only five heterozygous individuals detected were from Pará State. The most frequent genotype in the North region of Brazil was the H63D heterozygote, in both study groups. Our results contribute to the concept that the Brazilian Amazon region should not be regarded as a single entity in South America. These polymorphisms did not influence the symptoms of malaria in the population studied, as neither severe signs nor high parasitemia were observed. Therefore, different hereditary hemochromatosis diagnostic and control measures must be developed and applied within its diverse locations. Investigations are currently being carried out in our laboratory in order to determine the importance of the coexistence of hereditary hemochromatosis in patients affected by parasitic diseases, such as malaria. ©FUNPEC-RP.

The application of distributed virtual machines for enterprise computer management: A two-tier network file system for image provisioning and management

In order to simplify computer management, several system administrators are adopting advanced techniques to manage software configuration of enterprise computer networks, but the tight coupling between hardware and software makes every PC an individual managed entity, lowering the scalability and increasing the costs to manage hundreds or thousands of PCs. Virtualization is an established technology, however its use is been more focused on server consolidation and virtual desktop infrastructure, not for managing distributed computers over a network. This paper discusses the feasibility of the Distributed Virtual Machine Environment, a new approach for enterprise computer management that combines virtualization and distributed system architecture as the basis of the management architecture. © 2008 IEEE.

Categorização functional trófica das comunidades de macroinvertebrados de dois reservatórios na região centro-oeste do Estado de São Paulo, Brasil

The use of the concept of guild can be useful for the functional trophic categorization of communities, because there is no requirement identification of organisms in the level of species and not to treat each species as a separate entity. The aim of this study was to analyze the functional feeding groups (collectors-gatherers, collectors-filterers, shredders, predators and grazer-scrapers) of the macroinvertebrate communities of two reservoirs in the Midwestern region of São Paulo State. Sampling was carried out in rainy (March/April - 2001) and dry (July/August - 2001) seasons and the data obtained indicate that 'collectors-gatherers' is the most frequent guild. This fact suggests a great importance of organic matter as a food source in the diet of the macroinvertebrates analyzed.

Valores Referenciais para Procedimentos Odontológicos (VRPO) em Ortodontia

Introduction: The cost of orthodontic treatment is a very important issue. The aim of this study was to analyze the current Indicative Values for Dental Procedures (IVDP) for orthodontic procedures. Methods: Laws, dental entities papers and scientific literature were utilized. Results: Laws are too general and only offer abstract parameters when define remunerations. Current IVDP vary in the same State, according to the consultant entity. Dental entities interpret that general clinicians can practice Corrective Orthodontics, but new scientific studies begin to question this understanding. The Brazilian Association of Orthodontics and Dentofacial Orthopedics (ABOR) suggests that IVDP for orthodontic specialty must be formulated. Conclusion: Current IVDP are not standardized and are below the correct values for orthodontic procedures, because they are the mean of general clinicians and orthodontists remunerations; and ABOR is legally and ethically supported to claim specific IVDP for orthodontic specialty.

A tool to simplify the management of homogeneous and heterogeneous grids

To simplify computer management, several system administrators are adopting advanced techniques to manage software configuration on grids, but the tight coupling between hardware and software makes every PC an individual managed entity, lowering the scalability and increasing the costs to manage hundreds or thousands of PCs. This paper discusses the feasibility of a distributed virtual machine environment, named Flexlab: a new approach for computer management that combines virtualization and distributed system architectures as the basis of a management system. Flexlab is able to extend the coverage of a computer management solution beyond client operating system limitations and also offers a convenient hardware abstraction, decoupling software and hardware, simplifying computer management. The results obtained in this work indicate that FlexLab is able to overcome the limitations imposed by the coupling between software and hardware, simplifying the management of homogeneous and heterogeneous grids. © 2009 IEEE.

Early onset obsessive-compulsive disorder with and without tics

Introduction: Research suggests that obsessive-compulsive disorder (OCD) is not a unitary entity, but rather a highly heterogeneous condition, with complex and variable clinical manifestations. Objective: The aims of this study were to compare clinical and demographic characteristics of OCD patients with early and late age of onset of obsessive-compulsive symptoms (OCS); and to compare the same features in early onset OCD with and without tics. The independent impact of age at onset and presence of tics on comorbidity patterns was investigated. Methods: Three hundred and thirty consecutive outpatients meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for OCD were evaluated: 160 patients belonged to the early onset group (EOG): before 11 years of age, 75 patients had an intermediate onset (IOG), and 95 patients were from the late onset group (LOG): after 18 years of age. From the 160 EOG, 60 had comorbidity with tic disorders. The diagnostic instruments used were: the Yale-Brown Obsessive Compulsive Scale and the Dimensional Yale-Brown Obsessive Compulsive Scale (DY-BOCS), Yale Global Tics Severity Scale; and Structured Clinical Interview for DSM-IV Axis I Disorders-patient edition. Statistical tests used were: Mann-Whitney, full Bayesian significance test, and logistic regression. © MBL Communications Inc.

Úlcera de cameron como causa incomum de anemia por deficiência de ferro

Cameron ulcers are chronic linear lesions willing on the mucosal folds, the level of diaphragmatic impression, in patients with hiatal hernia. Its clinical relevance is due to the potential risk of gastrointestinal complications, such as acute or chronic bleeding and anemia. Usually, the diagnosis is incidental by upper gastrointestinal endoscopy. Proton pump inhibitors are essential for the conduct of cases and the administration of iron when the anemia is associated. Already, the benefit of surgery is in refractory cases. We present a case of this entity of a 50-year-old patient in postmenopausal who developed anemia due to iron deficiency and normal initial endoscopy.

Uma odisséia de quase meio século pelo espaço teatral paulistano, através da memória de um espectador movido a paixão e em permanente processo de formação

Pós-graduação em Artes - IA

Metodologia e diretrizes para desenvolvimento de um ambiente computacional para ensino a distância

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Análises moleculares e da presença de endobactérias de Camponotus textor Forel, 1899 (Hymenoptera, Formicidae)

Pós-graduação em Ciências Biológicas (Biologia Celular e Molecular) - IBRC

Análise, desenvolvimento e implantação de software para monitorização, controle e gerenciamento dos processos na condução de estudos clínicos em cancerologia

Pós-graduação em Pesquisa e Desenvolvimento (Biotecnologia Médica) - FMB

Papel da tomografia torácica e abdominal no estadiamento do carcinoma mamário localmente avançado

Pós-graduação em Cirurgia Veterinária - FCAV

Os não-anistiados: os militares da associação dos marinheiros e fuzileiros navais do Brasil

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Sob a vigência da Ancine (2001-2011): trajetória, mecanismos e a ingerência da economia da cultura na cinematografia

Pós-graduação em Ciências Sociais - FCLAR

A articulação comunitária e o Estado: limites e possibilidades dos CONSEGs em Marília/SP

Pós-graduação em Ciências Sociais - FFC