CHARACTERISTICS OF ARTERIAL-HYPERTENSION IN RESPONSE TO BOLUS INJECTION OF PHENYLEPHRINE IN ATROPINIZED PATIENTS

The changes of arterial pressure promoted by bolus injection of 50 mg phenylephrine (PHE) were studied in 20 atropinized patients (5 normal subjects, 13 patients with mitral valve disease, 1 patient with essential arterial hypertension and 1 patient with hypertrophic cardiomyopathy) submitted to routine catheterism. Patients with aortic valve disease, left ventricular outflow tract obstruction and intracardiac shunt were excluded from the study. All patients were in sinus rhythm, without heart failure. Arterial pressure started to increase at 14.8 +/- 5.4 s (range, 5.6 to 27 s; mean +/- SD) after PHE. There was an increase of 37.8 +/- 16.7 mmHg (range, 12.5 to 70 mmHg) in systolic pressure and of 26.6 +/- 11.1 mmHg (range, 7.5 to 42.5 mmHg) in diastolic pressure. Peak hypertension was attained at 36.6 +/- 16.4 s (range, 10.8 to 64.9 s) and hypertension continued for 176 +/- 92 s (range, 11 to 365 s). Heart rate was 114 +/- 21 bpm before PHE and 111 +/- 21 bpm (P<0.05) after PHE. There were no adverse events associated with intravenous PHE injection in any patient, in accordance with the general view that bolus injection of PHE is a safe and practical maneuver to promote arterial hypertension.

Role of roscovitine and IBMX on kinetics of nuclear and cytoplasmic maturation of bovine oocytes in vitro

The 3-isobutyl-1-methylxanthine (IBMX) is able to prevent resumption of meiosis by maintaining elevated cyclic AMP (cAMP) concentrations in the oocyte, and roscovitine, a purine known to specifically inhibit MPF kinase activity, maintains bovine oocytes at the germinal vesicle (GV) stage. The present study was conducted to analyze whether cytoplasmic maturation (examined by the pattern of cortical granule (CG) distribution) of bovine oocytes is improved during meiotic arrest with IBMX and roscovitine. Oocytes were matured in vitro in a 10% Knockout(SR) supplemented TCM-199 medium (Control) with either 0.5 mM IBMX or 25 mu M roscovitine (ROSC). Oocytes were stained with fluorescein isothiocyanate conjugated Lens culinaris agglutinin (FITC-LCA) for CG evaluation and with Hoechst 33342 for nuclear stage assessment. At 16 h of culture, the percentage of oocytes remaining in the GV stage was higher (P < 0.05) in the ROSC group (32.41%) compared with the Control and IBMX groups (8.61% and 9.73%, respectively). At 24h of culture, progression of meiosis to M II stage was retarded (P < 0.05) in the ROSC group (24.05%) compared to the Control (60.20%), whereas the IBMX group (33.88%) showed no significant difference to the other two groups. At 16h of maturation, the proportion of oocytes with CG in clusters (immature cytoplasm) was similar between the groups, as was the percentage of peripheral CG (mature) at 24h of maturation. The results of the present study demonstrated that the meiotic inhibitors IBMX and roscovitine delay the progression of nuclear maturation without affecting cytoplasmic maturation, assessed by the analysis of CG repositioning. (c) 2006 Elsevier B.V. All rights reserved.

An analytical and numerical study of plane change maneuvers using aerodynamic force

The goal of the present work is to analyze space missions that use the terrestrial atmosphere to accomplish orbital maneuvers that involve a plane change. A set of analytical solutions is presented for the variation of the orbital elements due to a single passage through the atmosphere, assuming that the interval the spacecraft travels through the atmosphere is not too large. The study considers both the lift influence on the spacecraft orbit as well as drag. The final equations are tested with numerical integration and can be considered in accordance with the numerical results whenever the perigee height is larger than a critical value. Next, a numerical study of the ratio between the velocity increment required to correct the semimajor axis decay due to the atmospheric passage and the velocity variation required to obtain the change in the inclination is also presented. This analysis can be used to decide if a maneuver passing through the atmosphere can decrease the fuel consumption of the mission and, in the cases where this technique can be used, if a multiple passage is more efficient than a single passage.

Effects of the eccentricity on the primaries in the gravitational capture phenomenon

Gravitational capture is a characteristic of some dynamical systems in celestial mechanics, as in the elliptic restricted three-body problem that is considered in this paper. The basic idea is that a spacecraft (or any particle with negligible mass) can change a hyperbolic orbit with a small positive energy around a celestial body into an elliptic orbit with a small negative energy without the use of any propulsive system. The force responsible for this modification in the orbit of the spacecraft is the gravitational force of the third body involved in the dynamics. In this way, this force is used as a zero cost control, equivalent to a continuous thrust applied in the spacecraft. One of the most important applications of this property is the construction of trajectories to the Moon. The objective of the present paper is to study in some detail the effects of the eccentricity of the primaries in this maneuver.

Strategies for plane change of Earth orbits using lunar gravity and derived trajectories of family G

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Alternative Transfers to the NEOs 99942 Apophis, 1994 WR12, and 2007 UW1 via Derived Trajectories from Periodic Orbits of Family G

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Effects of the eccentricity on the primames in the gravitational capture phenomenon

Gravitational capture is a characteristic of some dynamical systems in celestial mechanics, as in the elliptic restricted three-body problem that is considered in this paper. The basic idea is that a spacecraft (or any particle with negligible mass) can change a hyperbolic orbit with a small positive energy around a celestial body into an elliptic orbit with a small negative energy without the use of any propulsive system. The force responsible for this modification in the orbit of the spacecraft is the gravitational force of the third body involved in the dynamics. In this way, this force is used as a zero cost control, equivalent to a continuous thrust applied in the spacecraft. One of the most important applications of this property is the construction of trajectories to the Moon. The objective of the present paper is to study in some detail the effects of the eccentricity of the primaries in this maneuver.

Maxillary canine - First premolar transposition: Restoring normal tooth order with segmented mechanics

Tooth transpositions present at a relatively low incidence in the world population and primarily affect maxillary canines and premolars. Treatment of this disturbance should take into account aspects such as facial pattern, age, malocclusion, tooth-size discrepancy, stage of eruption, and magnitude of the transposition. Mechanics for correction should be entirely individualized, reducing the risks and adverse effects. Practitioners often select simpler options, indicating extraction of permanent teeth, which is an irreversible procedure that may bring about damages to the patient. This study presents a case report and treatment of unilateral transposition of maxillary canine and premolar with repositioning of affected teeth to their respective normal positions. © 2006 by The EH Angle Education and Research Foundation, Inc.

Mandible protrusion and decrease of TMJ sounds: An electrovibratographic examination

This study quantified by, electrovibratography, the amount of mandible protrusion required to decrease significantly temporomandibular joint (TMJ) vibratory energy as an aid in the diagnosis of the recapture of anteriorly displaced disk. Eighteen patients diagnosed as having anterior disk displacement with reduction and TMJ clicking were submitted to electrovibratographic examination at the first appointment and treated with a stabilizing appliance and anterior positioning appliance with 1 to 5 mm protrusion. Vibratory energy was checked in each of these positions. Baseline data were used as control. At the first appointment, the patients had vibrations with more elevated intensities at the middle and late phases of the mouth opening cycle. At only one clinical step, mandible protrusion was obtained with the anterior repositioning appliance, ranging from 1 to 5 mm protusion. At each new position, a new electrovibratographic exam was made. After the 5-mm mandibular projection, only 2 patients presented vibration, with means between 0.6 and 2.8 Hz. Data were analyzed statistically by ANOVA and Tukey's test (α=0.05). The outcomes of this study indicate that 3 mm is the minimum amount of mandible protrusion to significantly decrease the TMJ vibratory energy and to recapture the displaced articular disk.

Interplanetary natural routes via Moon and Lagrangiam points L1 and L2

Swing-by techniques are extensively used in interplanetary missions to minimize fuel consumption and to raise payloads of spaceships. The effectiveness of this type of maneuver has been proven since the beginning of space exploration. According to this premise, we have explored the existence of a natural and direct links between low Earth orbits and the lunar sphere of influence, to obtain low-energy interplanetary trajectories through swing-bys with the Moon and the Earth. The existence of these links are related to a family of retrograde periodic orbits around the Lagrangian equilibrium point L1 predicted for the circular, planar, restricted three-body Earth-Moon-particle problem. The trajectories in these links are sensitive to small disturbances. This enables them to be conveniently diverted reducing so the cost of the swing-by maneuver. These maneuvers allow us a gain in energy sufficient for the trajectories to escape from the Earth-Moon system and to stabilize in heliocentric orbits between the Earth and Venus or Earth and Mars. On the other hand, still within the Earth sphere of influence, and taking advantage of the sensitivity of the trajectories, is possible to design other swing-bys with the Earth or Moon. This allows the trajectories to have larger reach, until they can reach the orbit of other planets as Venus and Mars.(3σ)Broucke, R.A., Periodic Orbits in the Restricted Three-Body Problem with Earth-Moon Masses, JPL Technical Report 32-1168, 1968.

Severe fracture of the maxillary alveolar process associated with extrusive luxation and tooth avulsion: A case report

Aim: The aim of this report is to present a case of severe fracture of the maxillary anterior alveolar process with substantial bone dislodgement associated with extrusive tooth luxation and avulsion. Background: Dentoalveolar trauma is a challenge to dentistry, especially in young patients, for it can lead to early tooth loss which compromises oral function, esthetics, self-esteem, and alter the long-term plan of care for the victim. Case Report: A 12-year-old girl with severe dentoalveolar trauma to the maxillary anterior region presented for emergency care for her injury. Treatment consisted of fracture reduction of the alveolar process, repositioning of the teeth that had suffered extrusive luxation, placement of a semi-rigid splint, and suturing of soft tissue lacerations. The traumatized teeth presented with pulpal necrosis and were treated endodontically. After 24 months of follow up, the fracture of the alveolar process was completely healed and the displaced teeth presented no signs of ankylosis or root resorption. Summary: First-aid care contributed remarkably to this case allowing the re-establishment of esthetics, function, and patient's self-esteem. In spite of trauma extension the treatment outcomes were favorable. Clinical Significance: Cases of dentoalveolar trauma should be evaluated on an individual basis. However, early emergency management and adequate follow-up can prevent further complications and contribute to treatment success.

Bilateral lower second molar impaction in teenagers: An emergent problem

The frequency of simultaneously impacted second and third molars in teenagers is increasing and becoming a common occurrence in adolescent oral surgery practice. The traditional treatment is the removal of the third molar by conventional access but repositioning of the surgical flap to the distal face of the first molar can predispose to complications such as pericoronitis and delayed healing of the attached gingiva. We present a case in which we use the germectomy approach to remove the impacted third molar for the eruption of the second molar through a vestibular incision. This incision offers excellent bone exposure and exit route for the third molar without disturbing the gingiva attached architecture on the distal face of the first molar providing good healing environment.

The swing-by effect in the Vesta-Magnya case. Single and multiple encounters.

It was verified that the asteroid Magnya has some physical and chemical characteristics similar to the bodies from Vesta family. However, astronomical observations revealed that Magnya is distant from these bodies. In the present work, we assumed that Magnya originated from Vesta and we try to justify its current distant orbital location taking into account the effects of close encounters between Magnya and Vesta. The methodology adopted involved an analytical approach considering the technique of the gravity assisted maneuver, also known as swing-by. We found that the energy variation achieved through a single swing-by between Vesta and Magnya are very small when compared to the variation that would be required to change the orbit of Magnya. The effects of multiple close encounters were also considered and discussed. We concluded that the possibility of multiple encounters is limited, and therefore, that Magnya should suffer other perturbations (such as resonances, collisions or close encounters with other bodies, for instance) that would provide the supposed change in its orbit.

Determination of onboard coplanar orbital maneuvers with orbits determined using GPS

In the present paper a study is made in order to find an algorithm that can calculate coplanar orbital maneuvers for an artificial satellite. The idea is to find a method that is fast enough to be combined with onboard orbit determination using GPS data collected from a receiver that is located in the satellite. After a search in the literature, three algorithms are selected to be tested. Preliminary studies show that one of them (the so called Minimum Delta-V Lambert Problem) has several advantages over the two others, both in terms of accuracy and time required for processing. So, this algorithm is implemented and tested numerically combined with the orbit determination procedure. Some adjustments are performed in this algorithm in the present paper to allow its use in real-time onboard applications. Considering the whole maneuver, first of all a simplified and compact algorithm is used to estimate in real-time and onboard the artificial satellite orbit using the GPS measurements. By using the estimated orbit as the initial one and the information of the final desired orbit (from the specification of the mission) as the final one, a coplanar bi-impulsive maneuver is calculated. This maneuver searches for the minimum fuel consumption. Two kinds of maneuvers are performed, one varying only the semi major axis and the other varying the semi major axis and the eccentricity of the orbit, simultaneously. The possibilities of restrictions in the locations to apply the impulses are included, as well as the possibility to control the relation between the processing time and the solution accuracy. Those are the two main reasons to recommend this method for use in the proposed application.

Conservative condylectomy for management of osteochondroma of the mandibular condyle

Osteochondroma is one of the most common benign tumors of the skeleton. This tumor is rare in the craniofacial region, with the most common sites of occurrence being the coronoid process of the mandible and the mandibular condyle. Traditionally, the treatments of these lesions include total condylectomy or local resection of the lesion. Conservative condylectomy procedure with reshaping of the remaining condylar neck and repositioning of the articular disk has been suggested. This article aimed to describe a 35-year-old woman with osteochondroma in the left mandibular condyle who was treated by conservative condylectomy. The patient has been free of recurrence for 2 years, showing good aesthetic and functional stability. Copyright © 2013 by Mutaz B. Habal, MD.