Ocorrência de microrganismos periodontopatogênicos em pacientes com dependência química

Drug addiction won dramatic aspects in terms of its dimensions and the effects that it imposes. These chemical agents are able to reduce the immune reactivity and tissue repair, and enhance microbial aggression, aggravating the destruction of the periodontium and other side effects. This study aimed to evaluate the presence of key periodontal pathogens in the mouth of drug addiction patients, comparing it with individuals who do not exhibit this dependence, as well as assess the influence of oral conditions on the occurrence of such microorganisms. For this purpose, data on systemic health conditions, socioeconomic, patterns of licit or illicit drug consumption of 100 patients with chemical dependency kept in rehabilitation clinics and an equal number of non-dependent patients, who formed the control group were obtained. Intra and extraoral clinical examinations were performed and samples of supragingival and subgingival biofilm, saliva and mucous membranes were collected. The presence of the targeted microorganism was assessed by polymerase chain reaction (PCR). It was found that Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola showed close correlation with bone loss and gingival bleeding in drug addiction dependents and control group, but the oral mucous membranes and saliva of addicts showed higher occurrence of these pathogens.

Toxicity and loss of mitochondrial membrane potential induced by Alkyl Gallates in Trypanosoma cruzi

American trypanosomiasis or Chagas disease is a debilitating disease representing an important social problem that affects, approximately, 10 million people in the world. The main aggravating factor of this situation is the lack of an effective drug to treat the different stages of this disease. In this context, the search for trypanocidal substances isolated from plants, synthetic or semi synthetic molecules, is an important strategy. Here, the trypanocidal potential of gallates was assayed in epimastigotes forms of T. cruzi and also, the interference of these substances on the mitochondrial membrane potential of the parasites was assessed, allowing the study of the mechanism of action of the gallates in the T. cruzi organisms. Regarding the preliminary structure-activity relationships, the side chain length of gallates plays crucial role for activity. Nonyl, decyl, undecyl, and dodecyl gallates showed potent antitrypanosomal effect (IC50 from 1.46 to 2.90 μM) in contrast with benznidazole (IC50 = 34.0 μM). Heptyl gallate showed a strong synergistic activity with benznidazole, reducing by 105-fold the IC50 of benznidazole. Loss of mitochondrial membrane potential induced by these esters was revealed. Tetradecyl gallate induced a loss of 53% of the mitochondrial membrane potential, at IC50 value.

Microbiota bucal e sua relação com infecções oportunistas em pacientes edêntulos mantidos em unidades de terapia intensiva

Pós-graduação em Odontologia - FOA

Caracterização dos compostos derivados de furoxano como inibidores da atividade de bombas de efluxo em Mycobacterium tuberculosis e estudo da influência do efluxo e da halotolerância nos perfis de resistência do bacilo

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Identificação de cavidades naturais por meio de eletrorresistividade na região de São Pedro (SP)

The scope of this work is the study of natural cavities in gullies through geophysics. The studied area is located in the city of São Pedro (SP) more precisely in the gully of Tucunzinho. The historic of the area shows that, since the 60s there were problems with the high rate of erosion in the gully. In addition to increased erosion, there is the appearance of cavities inside responsible for rebates, aggravating the situation. Geophysical methods have been successfully applied in environmental studies since they are noninvasive, are fast and relatively inexpensive. In order to better understand the context of formation of the pipes in relation to local geology, three arrangements were compared for the method of Electrical Resistivity, Schlumberger, Wenner and Dipole-dipole. Then, it was possible to determine which one is the best for this type of study. According to the data obtained in the field, the Schlumberger array presents more consistent results in relation to the erosive context analyzed

Adequabilidade das áreas de vegetação ripária da microbacia do Córrego Comur - Botucatu (SP) em função da legislação ambiental

The inadequate soil use is an aggravating factor of the environmental degradation and ecological unbalance. The analysis of the use and covering of the soil, by information of Remote Sensing, constitutes a technique of great usefulness to the planning and administration of the ordered occupation and rational of the physical middle, besides making possible to evaluate and to monitor the preservation of areas of natural vegetation. This work sought to evaluate the conflicts of soil use in permanent preservation areas (PPA) in Stream Comur watershed - Botucatu (SP) through Geographical Information System and satellite image of 2009. The study area is located among the geographical coordinates 48o 23’ 04” to 48o 25’ 54” of longitude WGr. and 22o 44’ 42” to 22o 48” 12” of latitude S with an area of 1,719.6 ha. The results allowed to verify that the geoprocessing techniques were of fundamental importance in the identification of the areas of soil use, of APP and of conflicts among use and PPA where it leaves of the areas of APP is being used inadequately. In terms of environmental sustainability, it can be deduced that the watershed is very unfavorable, once it presents 70.67% of area used inadequately with sugarcane and pasture.

Planejamento do meio físico a partir de uma abordagem da técnica de capacidade de uso da terra na sub-bacia dso Rio das Pedras - Itatinga - SP

The study aimed mapping of the land use capacity classes for the Rio das Pedras watershed, Itatinga-SP in order to provide another mechanism of environmental planning for the studied area. It was used 1:10,000 topographic letters for the slope map generation which was overlaid with the studied area soil map. It was applied the judgment table criteria method, for generation of land use capacity map of the studied area. It were identified the following results: First, class III with constraints in relation of low fertility and restrictions about erosion risks on high slope areas. Second, class VI with the same characteristics of class III however with the presence of an aggravating factor of sand texture in all horizons, resulting in high risks of erosion events, especially in high slopes areas, and contamination by pollutants due the high soil permeability. Conclusions: It was verified that the more critical regions for land use capacity classes were VIs and mainly VIes class. The last one has more high relief areas and the presence of Neossolo Quartzarenico soil, with a big erosion propensity. The land use capacity map allow making different decisions for each region of the watershed respecting their individual characteristics.

Avaliação da atividade anti-hRSV da quercetina e seus derivados acetilados

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)