Atividade de estudo como fundamento do desenvolvimento do pensamento teórico de crianças em idade escolar inicial

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

O trabalho de Sísifo no sertão: uma análise de Vidas Secas

This paper revisits the work Vidas Secas, by Graciliano Ramos, in search of a literary analysis, observing the narrative aspects of time, space and characters, from the myth of Sisyphus's perspective, the existentialist philosophy of Sartre and Camus and theory the eternal return of Nietzsche. With the use of these special lenses, intended to show how this work is able to generate the effect of absurdity in the reader, through a narrative construction that brings out the absolute lack of meaning and purpose of those lives, but still, unlike than one would tend to conclude, builds characters who pass by a mere determinism of the environment and act in the world through freedom possible within all disturbing limitations imposed on them

Educação, verdade e valor: diálogo com Nietzsche

This article shows some reflections on the dilemmas of contemporary education, especially those that go without a horizon of truth and value, that are foundation and justification for the setting up of the modern school. Such reflections are grounded in the texts of Friedrich Nietzsche to discuss the dissolution of metaphysics, regarded here as an element of destabilization of the symbolic repertoire of the school. It is suggested at the end, the recovery of the interpretive act as an alternative to the emptying of the concepts of truth and value and recognition of dialogue as a privileged place to get closer to temporary and circumstantial truth.

Green tea polyphenol epigallocatechin-3-gallate and cranberry proanthocyanidins act in synergy with cathelicidin (LL-37) to reduce the LPS-induced inflammatory response in a three-dimensional co-culture model of gingival epithelial cells and fibroblasts

Objectives: The human antimicrobial peptide cathelicidin (LL-37) possesses anti-inflammatory properties that may contribute to attenuating the inflammatory process associated with chronic periodontitis. Plant polyphenols, including those from cranberry and green tea, have been reported to reduce inflammatory cytokine secretion by host cells. In the present study, we hypothesized that A-type cranberry proanthocyanidins (AC-PACs) and green tea epigallocatechin-3-gallate (EGCG) act in synergy with LL-37 to reduce the secretion of inflammatory mediators by oral mucosal cells. Methods: A three-dimensional (3D) co-culture model of gingival epithelial cells and fibroblasts treated with non-cytotoxic concentrations of AC-PACs (25 and 50 mg/ml), EGCG (1 and 5 mg/ml), and LL-37 (0.1 and 0.2 mM) individually and in combination (AC-PACs + LL-37 and EGCG + LL-37) were stimulated with Aggregatibacter actinomycetemcomitans lipopolysaccharide (LPS). Multiplex ELISA assays were used to quantify the secretion of 54 host factors, including chemokines, cytokines, growth factors, matrix metalloproteinases (MMPs), and tissue inhibitors of metalloproteinases (TIMPs). Results: LL-37, AC-PACs, and EGCG, individually or in combination, had no effect on the regulation of MMP and TIMP secretion but inhibited the secretion of several cytokines. ACPACs and LL-37 acted in synergy to reduce the secretion of CXC-chemokine ligand 1 (GRO-a), granulocyte colony-stimulating factor (G-CSF), and interleukin-6 (IL-6), and had an additive effect on reducing the secretion of interleukin-8 (IL-8), interferon-g inducible protein 10 (IP-10), and monocyte chemoattractant protein-1 (MCP-1) in response to LPS stimulation. EGCG and LL-37 acted in synergy to reduce the secretion of GRO-a, G-CSF, IL-6, IL-8, and IP-10, and had an additive effect on MCP-1 secretion. Conclusion: The combination of LL-37 and natural polyphenols from cranberry and green tea acted in synergy to reduce the secretion of several cytokines by an LPS-stimulated 3D coculture model of oral mucosal cells. Such combinations show promising results as potential adjunctive therapies for treating inflammatory periodontitis.

A abdução em Peirce: um estudo hermenêutico

Pós-graduação em Educação Matemática - IGCE

A assistência social e o trabalho com as pessoas em situação de rua no CREAS: um campo de intercessão

Pós-graduação em Psicologia - FCLAS

Pedagogical practices carried out during an in-service teachers education project: approaching history and philosophy of science to physics teaching

We report here part of a research project developed by the Science Education Research Group, titled: "Teachers’ Pedagogical Practices and formative processes in Science and Mathematics Education" which main goal is the development of coordinated research that can generate a set of subsidies for a reflection on the processes of teacher training in Sciences and Mathematics Education. One of the objectives was to develop continuing education activities with Physics teachers, using the History and Philosophy of Science as conductors of the discussions and focus of teaching experiences carried out by them in the classroom. From data collected through a survey among local Science, Physics, Chemistry, Biology and Mathematics teachers in Bauru, a São Paulo State city, we developed a continuing education proposal titled “The History and Philosophy of Science in the Physics teachers’ pedagogical practice”, lasting 40 hours of lessons. We followed the performance of five teachers who participated in activities during the 2008 first semester and were teaching Physics at High School level. They designed proposals for short courses, taking into consideration aspects of History and Philosophy of Science and students’ alternative conceptions. Short courses were applied in real classrooms situations and accompanied by reflection meetings. This is a qualitative research, and treatment of data collected was based on content analysis, according to Bardin [1].

Política, resistência e vida na função-educador: contribuições de Foucault

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Um exercício de pensamento: entre a fotografia e a escrita

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)