397 resultados para Transplante de Ilhotas de


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Pós-graduação em Agronomia (Horticultura) - FCA

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Hepatitis C virus (HCV) is a serious public health problem and is the leading cause of liver transplantation due to cirrhosis and hepatocellular carcinoma. In Brazil, it is estimated that there are approximately 2 to 3 million HCV chronic carriers. Few data regarding HCV infection are available in West region of Minas Gerais State. Due to the absence of an effective vaccine against this important human pathogen and the high costs of antiviral treatment, it is important to conduct epidemiological studies with the purpose of carry out the planning and implementation of measures to prevent hepatitis C in different populations. Therefore, the aim of this study is to describe the epidemiological aspects of HCV patients from West region of Minas Gerais State, Brazil. Sociodemographic data and risk factors for HCV infection were determined from 74 HCV patients from Uberlandia city (Minas Gerais State). Reactive anti-HCV sera samples were submitted to HCV RNA and genotype detection. Most of individuals were male (63.5%) with mean age of 51 years and presenting low socioeconomic status. HCV genotype was determined among 40 samples and the frequencies were: genotype 2 (45%), 1 (37.5%) and 3 (17.5%). Hepatitis C virus (HCV) infection was common among male and low socioeconomic status individuals.

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Cell therapy has frequently been reported as a possible treatment for spinal trauma in humans and animals; however, without pharmacologically curative action on damage from the primary lesion. In this study, we evaluated the effect of administering human adipose-derived stem cells (hADSC) in rats after spinal cord injury. The hADSC were used between the third and fifth passages and a proportion of cells were transduced for screening in vivo after transplantation. Spinal cord injury was induced with a Fogarty catheter no. 3 inserted into the epidural space with a cuff located at T8 and filled with 80 mu L saline for 5 min. The control group A (n = 12) received culture medium (50 mu L) and group B (n = 12) received hADSC (1.2 x 10(6)) at 7 and 14 days post-injury, in the tail vein. Emptying of the bladder by massage was performed daily for 3 months. Evaluation of functional motor activity was performed daily until 3 months post-injury using the Basso-Beattie-Bresnahan scale. Subsequently, the animals were euthanized and histological analysis of the urinary bladder and spinal cord was performed. Bioluminescence analysis revealed hADSC at the application site and lungs. There was improvement of urinary bladder function in 83.3% animals in group B and 16.66% animals in group A. The analysis of functional motor activity and histology of the spinal cord and urinary bladder demonstrated no significant difference between groups A and B. The results indicate that transplanted hADSC improved urinary function via a telecrine mechanism, namely action at a distance.

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Fueron conducidos dos experimentos individuales en el municipio de Mossoró, Rio Grande do Norte, Brazil. Se empleó dos cultivares de melón, ‘Olimpic express’ (del tipo Cantaloupo) e ‘Iracema’ (del tipo Amarillo), para evaluar el crecimiento y la acumulación de macronutrientes, bajo el diseño de bloques al azar con siete tratamientos (épocas de muestreo) y tres repeticiones. Los muestreos de plantas fueron realizados a los 14, 21, 28, 35, 42, 49 y 56 días después del trasplante (DDT). El crecimiento fue lento hasta 28 DDT en ambos cultivares evaluados, intensificándose en el periodo siguiente, alcanzando a los 56 DDT, 246.4g planta-1 , en ‘Olimpic express’,y 266.9 g planta-1, en ‘Iracema’, siendo la materia seca (MS) de los frutos correspondientes a 60% y 64% de la MS total, respectivamente. Mayores acumulaciones de N, P y K fueron obtenidos en los frutos, mientras de Ca, Mg y S en las hojas. Al final del ciclo, en ‘Olimpic express’, cuya productividad fue de 32 t ha-1, fueron acumulados 173.4, 110.1, 101.1, 26.9, 15.6 y 13.5 kg ha-1 de K, Ca, N, Mg, S y P, respectivamente, y en ‘Iracema’, cuya productividad fue de 38 t ha-1, fueron acumulados 136.0, 93.9, 84.1, 22.6, 15.4 y 9.5 kg ha-1 de K, N, Ca, Mg, S y P, respectivamente. En relación al total acumulado, las exportaciones de N, P, K, Ca, Mg y S en los frutos fueron de 61, 73, 66, 9, 35 y 39% (‘Olimpic express’)y 58, 70, 55, 6, 33 y 41% (‘Iracema’). Con una menor producción de frutos y una mayor acumulación de nutrientes, ‘Olimpic express’ ha demostrado ser menos eficiente en el uso de nutrientes que ‘Iracema’.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Cyclosporin A (CsA) is a potent immunosuppressor used in organ transplantation and in the management of various autoimmune diseases. Recent studies have shown that CsA stimulates deposition of cementum on root surfaces. The aim of this study was to evaluate the periapical cementum thickness and the apical foramen width in CsA-treated rats. Rats weighing 50 g were treated with a daily injection of 10 mg/kg body weight of CsA in the chow for 60 days. The cementum of the mandibular 1st molars was histologically and morphometricaly examined by analysis of 5-microm-thick serial buccolingual paraffin sections stained with hematoxylin and eosin. Histometric and stereologic analyses revealed the presence of large amounts of cementum in all root surfaces, particularly abundant in the periapical region and obliterating the foramen. The volume density of cementoblasts did not increase. Five to 90 days after the termination of CsA therapy, there was no reduction of cementum thickness. These results suggest that cementum deposition is not reversible after cessation of CsA treatment.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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For oral rehabilitation with implant-supported prostheses, there are required procedures to create the bone volume needed for installation of the implants. Thus, bone grafts from intraoral or extraoral donor sites represent a very favorable opportunity. This study aimed to review the literature on the subject, seeking to discuss parameters for the indications, advantages and complications of techniques for autogenous bone grafts.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Objective This study assessed early manifestations of metabolic syndrome determinants in patients submitted to hematopoietic stem cell transplantation. Methods Twenty-seven individuals participated in the study (20 with autologous and 7 with allogeneic hematopoietic stem cell transplantation). Anthropometric variables and biochemical indicators of lipid and glucose metabolism were determined before and 100 days after hematopoietic stem cell transplantation.Results The mean total cholesterol (p=0.086), very low density lipoprotein-cholesterol (p=0.069) and triglycerides (p=0.086) of all patients did not change significantly between the two study periods, but when the patients were separated by type of hematopoietic stem cell transplantation, triglycerides and very low density lipoprotein-cholesterol were close to the critical level of significance for individuals with allogeneic hematopoietic stem cell transplantation (p=0.060) and total cholesterol was significant in individuals with autologous hematopoietic stem cell transplantation (p=0.027). Anthropometric variables did not change significantly between before and 100 days after hematopoietic stem cell transplantation. Conclusion Metabolic syndrome risk factors may be associated with lipid metabolism in the early phase of allogeneic and autologous hematopoietic stem cell transplantation.