Estudo sobre o potencial de alguns latossolos da região do Vale do Paraíba, estado de São Paulo, para uso em camadas estruturais de pavimentos de baixo volume de tráfego

The main purpose of this research is to raise, through lab rehearsals, the geometric properties of some oxisols from the region of Vale do Paraíba as well as comparing them to demands prescribed by Technical Specifications ESP08/05 of the Road Department of the State of Paraná, for sub-base or fine grained lateritic soil base (SAFL) and in the Technical Specification ET-DEP00/006 of the Road Department of the State of São Paulo (DER/SP) for subbase or crushed stone base. According to the results that were obtained it will be feasible to appraise the usage of these sorts of soils in structure layers of low-weight traffic pavements

Síntese de pró-fármaco recíproco com potencial atividade anti-psoríase

A psoríase é uma doença inflamatória crônica da pele caracterizada pela hiperproliferação dos queratinócitos. Apesar de não se conhecer a causa da doença, sabe-se que ela envolve uma série de alterações no sistema imune inato e adquirido, principalmente. Entre essas alterações estão o aumento da produção de citocinas pró-inflamatórias como a interleucina 1 e o fator de necrose tumoral α (TNF- α). O metotrexato é um antinéoplásico análogo do ácido fólico, mas que tem seu uso consolidado no tratamento da psoríase. Sua ação principal está na inibição indireta de células em crescimento exponencial, como células tumorais e em proliferação. A modulação dos níveis de TNF-α vem a ser uma boa alternativa para o controle da psoríase. A talidomida foi o primeiro fármaco que desempenhava tal atividade, mas devido a sua teratogenicidade deixou de ser utilizada. Descobriu-se que a função antiinflamatória estava relacionada à parte ftalimídica da molécula. Então, a partir daí passou-se a sintetizar derivados que pudessem ter a mesma atividade, porém com toxicidade reduzida. Esse trabalho visa a síntese de um pró-fármaco recíproco, com a finalidade de uso tópico, unindo as atividades antiinflamatórias e antiproliferativa do metotrexato e imunomoduladora do derivado ftalimídico, o cloreto de 4-(1,3-dioxo-1,3-diidro-2H-isoindol-2-il)benzenosulfonil, para a redução de efeitos adversos e toxicidade decorrente do tratamento, visando a melhora da qualidade de vida do paciente

Híbridos contendo nanopartículas de ZnO dopadas com Co para potencial liberação controlada de fármaco anticancerígeno

O câncer é uma patologia crescente entre a população atual e segundo a Organização Mundial da Saúde (OMS) está entre as principais causa de morte mundialmente. A relevância do perfil epidemiológico dessa doença desperta interesse em desenvolver materiais que forneçam qualidade de diagnóstico e tratamento. Na busca pela qualidade da saúde, o desenvolvimento de materiais que possam liberar fármacos de forma controlada e em um sítio alvo, tem se tornado cada vez mais intensa, pois estes materiais podem diminuir os efeitos colaterais além de aumentar a porcentagem do medicamento em ação direta com o sítio alvo. Neste contexto, materiais poliméricos híbridos orgânico-inorgânicos do tipo ureasil-poliéter que são biocompatíveis, transparentes e flexíveis permitem a incorporação de uma série de compostos, dentre os quais, nanopartículas e fármacos. Com base nestes argumentos, neste trabalho foi desenvolvido dispositivo de liberação controlada de fármacos formado por materiais poliméricos ureasil-poliéter contendo nanopartículas de ZnO dopadas com cobalto. A conjugação destes diferentes materiais teve como objetivo conferir as propriedades individuais de cada componente no mesmo material: o cobalto devido as suas propriedades magnéticas pode guiar o dispositivo de liberação de fármaco até o órgão doente; o ZnO devido às propriedades luminescentes permite monitorar a posição do dispositivo dentro do corpo humano.

O papel do gado como potencial agente dispersor de sementes de leguminosas forrageiras

Não disponível.

Análise do potencial bioindicador do diplópodo Rhinocricus padbergi exposto a substrato contendo lodo de esgoto por meio de estudos histológico e histoquímico do tubo digestivo

Não disponível

Avaliação do potencial anti-inflamtório de extratos isolados de microrganismos marinhos

O Brasil possui cerca de 8.000 quilômetros de costa litorânea, a segunda maior do mundo depois da Austrália. Apesar do território marítimo brasileiro apresentar 3,6 milhões de quilômetros quadrados de extensão, as pesquisas relacionadas ao levantamento de potenciais recursos brasileiros obtidos a partir de espécies marinhas ainda são incipientes. O interesse de empresas farmacêuticas por compostos isolados de microrganismos vem crescendo lentamente devido às dificuldades até então encontradas para o isolamento e cultivo dos mesmos. No entanto, com o avanço destas técnicas, recentes estudos demonstram que compostos isolados de microrganismos marinhos representam uma rica e ainda pouco explorada fonte de novos compostos bioativos (estima-se que apenas 1% dos microrganismos marinhos foram cultivados e identificados). Recentes estudos que apontam para o potencial farmacológico de compostos isolados de microrganismos nos instigaram à busca de novos fármacos com potencial imunoestimulador não apenas a partir de invertebrados, mas também de microrganismos marinhos e seus metabólitos secundários bioativos. Neste trabalho, após avaliação do potencial imunomodulador de extratos brutos derivados de microrganismos marinhos, obteve-se a substância pura Pirenocine A, isolada do fungo Penicillium paxilli, que mostrou-se promissora devido sua capacidade de diminuir a produção de óxido nítrico e citocinas pró-inflamatórias em macrófagos estimulados com LPS tanto no protocolo profilático quanto terapêutico ...

Potencial de aproveitamento de agregados reciclados de resíduos da construção e demolição

CONAMA Resolution 307 / 02, in Article 4, states that the primary goal of those involved in the reuse process of construction and demolition waste is not the generation of such wastes, secondarily is the reduce, reuse, recycling and proper disposal of such material. The disposal problem of large volumes of waste generated coupled with the scarcity of natural resources and environmental degradation involved in the extraction process of such materials resulted in several studies, that after many analyzes proposed various forms of reuse and recycling . The NBR 15.116/04 provides requirements for the use of recycled aggregates in paving and concrete without structural function. This work aims to show the usage potential of recycled aggregates from waste generated in construction and demolition sampled Group AB Areias, Pindamonhangaba (SP) in order to meet the standards in Brazil, as well as the environmental contribution by reducing the use of raw materials extracted from nature. After stabilization and particle size analysis of the California Bearing Ratio and Proctor, obtained mixtures of recycled aggregates showed higher values submitted by the minimum standards related, with excellent potential for use in paving

Avaliação dos resíduos sólidos gerados no Restaurante Universitário da UNESP de Rio Claro: uma análise do potencial de compostagem

A consequence of population growth is the increased generation of solid waste, which requires environmentally and economically viable suitable disposal sites. The scarcity of such sites makes necessary to adopt non-generation measures, reduction, reuse , recycling and treatment of solid waste before final disposal of waste. This paper presents the quantification and qualification of organic waste generated in each sector of the University Restaurant (UR) , by proposing indicators of waste generation per meal (index of waste) . Then, from the characterization of the waste management practices adopted internally, evaluates the potential deployment of the composting process for organic waste, with signaling for opportunities to improve waste management. The diagnosis of waste generation was made based on data collected during the period of 10 days. The waste were classified into 3 groups (organic, recyclable and waste) in each sector of the restaurant ( pre preparation , kitchen and tray return) . The results reveal that 33 % of the waste generated in the UR currently has the potential to be composted in a suitable place on campus. Every meal served generat approximately 124g of waste, of which 35g are organic waste of the pre preparation sector, 49g are remnants of food in the tray’s return and 40g are other kinds of waste, including recyclable and non recyclable. You can still get a higher percentage of compostable if the trays pre-wash is not performed with detergent and water. To minimize the generation of waste trays can be replaced by plates and skimmers and ladles can be replaced by smaller ones. The food exposed in the counter but not consumed, can be distributed to students after the restaurant is closed so this material would not be disposed in the garbage

O potencial transformador das relações públicas comunitárias: um estudo de caso sobre o projeto de extensão Taquara

The present work refers to graduation media with specialization in Public Relations and intends to observe the potential for social transformation present in the work of the Community public relations and critical development of the profession in a community, from the perspective of economics concepts creative. Specifically highlights this practice in the community and region of Bauru from observation and evaluation of the work done by the author for two and a half years in project Taquara extension, along with Project Bamboo, which has bamboo as a focus of study and its extension actions. Encompasses the perceptions of the author on existing work in the third sector challenges and observes the realization of a participatory planning process and creating a communication plan as a contribution to the growth of the project

Mapeamento geológico, caracterização litoquímica e potencial econômico do corpo de cromitito de Cedrolina, Santa Terezinha de Goiás - GO

Studies of mafic-ultramafic bodies have been carried out through the years due to their great use on the interpretation of geochemical and geotectonic processes that took place in Earth's history. Amongst them, chromitites are notably recognized for being excellent indicators of their parental magma chemistry and of different geotectonic environments, as well for frequently containing associated noble metals mineralization. Thus the investigation of one of this ultramafic bodies that occurs inside the Pilar de Goiás Greenstone Belt was proposed, resulting in a detailed map of the chromitites and country rocks, as well as innumerous new data on the chemistry of chromite and associated matrix and accessory minerals. These studies were based upon geological field observations, optic and Scanning Electron Microscope (SEM), besides electron microprobe and cathodoluminescence analysis performed at the “Eugen F. Stumpfl Laboratory” of the Montanuniversität Institute of Resource Mineralogy, University of Leoben - Leoben, Austria. The chromitites are composed of 40-70% in volume of chromite (~50% on average), 14-55% of talc (~30% on average), 3-60% of chromium rich chlorite (~20% on average), traces to 4% of iron hydroxides and traces to 3% of rutile (1,5% on average). The chromite occurs as large spherical aggregates or as fine grained subhedral crystals disseminated in the matrix. This aggregates have diameters of 0.3-1.5 cm (1 cm on average) and are extremely well rounded, massive to intensively fractured, and commonly deformed to ellipsoids. When observed under the microscope, these aggregates show well rounded to slightly irregular borders, but on their interiors, these structures are represented by fine to medium grained euhedral to subhedral chromite crystals that have sharp contacts between themselves. The rock's matrix is basically made of chlorite and talc that define a metamorphic foliation (Sn), being the talc an alteration product ...

Mercado GLS: como obter sucesso com o público de maior potencial da atualidade

The current paper presents itself as a pioneer and innovative initiative of thinking communication applying it to a very specific target audience: the homosexual segment. In the course of this study, peculiar characteristics concerning the needs and aspirations of this group have been analyzed. Data confirm this segment has one of the most meaningful market potential nowadays. In view of this, it has been carried out a detailed analysis about a Brazilian company entrepreneurship which proposed itself to enter into connection with this target. Finally it is made available to the reader a guide containing the guidelines and all the appropriate practices by the time a company decides to encompass the gay segment

Seleção de micro-organismos com potencial de biodegradação de hidrocarbonetos e biodiesel

The oil and biodiesel are oily substances which, if spilled or thrown out in the environment, can cause serious damages. In this context, bioremediation techniques can be used to the recovering of sites degradated by mineral or vegetable oil, besides them, the biodegradation. However, it is necessary that there are microorganism strains used to degradate the contaminant, previously selected for the fast, efficient and minimum impact remediation. The main objective of this study was to isolate microorganism strains coming from different ecological recesses and verify their potentiality on biodegradating oil and biodiesel. Strains of bacteria, fungi and yeasts were isolated from soils contaminated by hydrocarbons (diesel, gasoline, grease) before, by doing striations on culture plates. On the biodegradation tests, it was used the redox indicator, 2,6-dichlorophenol indophenol (DCPIP), then, after the indicador’s discoloration, the absorbance of the suspension obtained was measured. 46 different microorganism strains were isolated, and the oil, when it was used as a carbon resource, it was degradate easier than the biodiesel. The experiments showed that, in a period, the site impacted by oil spills recovers itself by the biodegradation, in aerobic conditions, by the redox activity.

SIG e álgebra de mapas na elaboração de um mapa de potencial de erosão em áreas de silvicultura

Cette étude visait à générer une carte du potentiel d'érosion pour la Ferme Santa Edwirges, située à Lorena /SP. Les résultats ont etés classifiés en faible, modéré, élève et très élève potentiel d'érosion et la carte obtenue a été comparé par rapport aux autres cartes existantes pour la zone d'étude. La méthodologie proposée se basant sur une application qualitative simple L’équation Universelle de Perte de Sol (USLE ou EUPS), en considérant les parties de l'équation: érodibilité, la topographie et l'utilisation des terres. Les donnés ont etés intégrés par l'algèbre de carte dans l’environnement SIG de ArcGIS. Pour la représentation de chacune de ces parcelles, nous avons utilisé une carte des formations superficielles de la ferme, généré à partir d'une ré-interprétation de la carte géologique, une carte de la pente et une carte d'utilisation des terres, attribuant un poids d’important pour chaque catégorie de ces cartes dans le processus d'érosion et dans l'algèbre proposée. Les résultats obtenus sont compatibles avec les zones identifiées comme les plus critiques sur terrain. La ferme a été identifiée comme de potentiel d'érosion modérée et la partie sud de la ferme le plus critique, suivi du groupe conduit par la zone de cisaillement, par contre les plaines proches des rivières ont eté identifié comme la zone plus stable avec moins de potentiel d'érosionDe la comparaison des résultats de ce travail et d'autres qui ont fait antérieurement dans la zone d’intéresse, qui ont utilisé les paramètres géotechniques dans la représentation de l'érosivité des sols, nous avons pu voir des résultats similaires, en particulier dans les zones à potentiel élevé et faible pour l'érosion. De la discussion et analyse des résultats, la méthodologie proposée à eté validée

Um Estudo da modelagem matemática na educação matemática e seu potencial para o desenvolvimento do pensamento crítico

The implementation of mathematical modeling curricula represents a great challenge, both for teachers and students, since it escapes the traditional teaching methodology, i.e. when the teacher speaks to his/her students. This work presents, at least, one possible way of implementing mathematical modeling inside the classroom, and how this way encourage critical thinking in students. I see mathematical modeling as an opportunity to minimize student's rejection and increase their interest for mathematics, promoting their competencies to give points of scene in every day situations. The history of mathematics shows that mathematical modeling had developed since almost the beginning of human live, when men needed to solve problems that arose in the course of his life. Mathematics has become more and more abstract, but it is important to recall what was originated it. In this way, it is possible to make this subject matter more meaningful to students. I will make an introduction of mathematical modeling, presenting some important definitions. Based on this framework, I will present a classroom instruction understand on a 7 th grade classroom by myself. With this in instruction I sustain the idea that mathematical modeling has, in fact, a great potential to improve the quality of mathematics teaching. I also sustain that, the development of critical thinking, as a competence, way be achieved with it

Análise do corpo gorduroso do diplópodo Rhinocricus padbergi para verificação de seu potencial bioindicador de solos impactados

Não disponível