323 resultados para Proposição


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Pós-graduação em Serviço Social - FCHS

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Pós-graduação em Estudos Linguísticos - IBILCE

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Coordination compounds of trivalent lanthanides cations with diphenylphosphinate are originated from direct reaction between a lanthanide salt and diphenylphosphinic acid. These complexes have peculiar and intriguing features, as (i) quickly obtainment through wet process precipitation, (ii) appreciable thermal stability, similar to inorganic phosphates, (iii) polymeric structure, and consequently, (iv) low solubility in both polar and non-polar solvents. Nowadays, coordination polymers are classified as coordination networks or, in case of porous materials, as metal-organic frameworks (MOFs). By this study, we aim to determine some optical properties of rare-earth diphenylphosphinate (RE = La3+, Eu3+, Gd3+, Lu3+) and conduct an updated classification of these compounds, bringing more details of its structure and the possible proposal of new materials with applications in lighting, detection of ionizing radiation and magnetism. The complexes of trivalent rare-earth cation with diphenylphosphinate were prepared by direct mixture of diphenylphosphinic acid with rare-earth metal chloride, both in ethanolic solution. The solution of diphenylphosphinic acid was kept in a beaker under constant stirring with pH measurements of the solution and gadolinium chloride solution was then dripped slowly with the aid of a burette until its complete addition; the following metal:ligand molar ratios were tested: 1:1, 1:2, 1:3, 2:1 e 3:1. The compounds were characterized by spectroscopic and structural techniques. By Fourier Transform Infrared Spectroscopy (FT-IR), it was possible to check the total ionization of diphenylphosphinic acid in synthesized complexes, confirmed by the absence of the band type A, B, C related to ѵ(O-H) of the acid (2663 cm-1, 2168 cm-1, 1684 cm-1), as well as the disappearance of ѵ(P-OH)=961 cm-1. Furthermore, the occurrence of bands shifts of ѵ(POO-) [symmetrical and asymmetrical] of...

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Survivin protein is an inhibitor of apoptosis that plays a role in cell cycle control and the mechanism of carcinogenesis. The aim of this study was to verify the clinic pathological correlation of survivin expression in exfoliative cytology of chronic smokers, mucosa of patients with intra-oral squamous cell carcinoma (OSCC) and also from mucosa after surgical removal of OSCC. Patients were divided in 03 groups: Group 1: 26 patients who smoked more than 20 cigarettes/day/10years with no history of oral malignant neoplasm, or any clinical sign visible at examination. Group 2: 26 patients who had OSCC and Group 3: 22 patients surgically treated of OSCC for at least 01 month. Immunohistochemistry of the smears from each group was analyzed by light microscopy to extent and intensity of survivin positive cells. Survivin expression was observed in 100% of cases in group 1, 88.5% in group 2 and 100% in group 3. Groups 1 and 3 showed cytoplasmic expression in 100% of the cases, while group 2 showed it in 87.5%. Cytoplasmic and nuclear expression was 7.69% observed only in group 2. The results were association with clinicopathological data by Fisher's exact test and it was significant to smoke cessation in group 2 on intensity (p=0.015) of survivin expression. The intensity of survivin expression was related to smoking cessation in group 2. Smoking history (pack/years) showed no influence survivin expression

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O Brasil é considerado um grande produtor e consumidor de carnes, leite e alimentos de origem animal e os medicamentos veterinários têm sido amplamente utilizados na criação dos animais destinados ao consumo humano, com o intuito de prevenir o aparecimento de doenças e também como promotores de crescimento. Os fármacos utilizados para esta finalidade, no entanto, podem ocorrer nos alimentos derivados desses animais tratados, com conseqüências sobre a saúde humana. Além das substâncias utilizadas intencionalmente, a contaminação ambiental ou a presença de contaminantes em rações constitui uma fonte potencial de compostos cuja concentração no alimento final processado pode exceder os limites de segurança estabelecidos para garantir a saúde humana. Com o intuito de promover maior segurança alimentar, no Brasil, foram estabelecidos os programas PNCRC e o PAMVet, que são responsáveis pelo monitoramento da presença de substâncias ilegais (como os antimicrobianos nitrofuranos) e também, visam o controle do Limite Máximo de Resíduos (LMR). O objetivo do presente trabalho é reunir e discutir as informações sobre os principais resíduos e contaminantes de medicamentos veterinários em alimentos de origem animal no Brasil, assim como as publicações referentes às avaliações mais recentes desses produtos alimentícios presentes no mercado brasileiro. Estas informações serão utilizadas para novas discussões relacionadas ao uso adequado de medicamentos veterinários e à proposição de estudos de farmacocinética que poderão fundamentar o estabelecimento do período de carência para esses produtos farmacêuticos.

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Pós-graduação em Geografia - IGCE