Síntese, caracterização e avaliação farmacológica de derivados N-acilhidrazônicos para a prevenção de aterotrombose

Atherosclerosis is a chronic inflammatory disease characterized by accumulation of lipid and fibrous components in arterial vessels, giving rise to atheromas. Development of Atheromatou plaques leads to arterial steatosis, triggering ischemic events. Atherotrombosis has a strong correlation with atherosclerosis, where rupture of atheromatous plaques cause release of vessel wall's pro-thrombotic components, activating platelet aggregation and thromosis. Due to the major role played by platelets on thrombus-embolic conditions, drugs that inhibit platelet aggregation demonstrate great relevance for atherothrombosis prevention, reducing patient mortality. Currently, there are a variety of drugs acting on several different targets, preventing platelet activation. However, these therapies demosntrate side effects such as thrombocytopenia, neutropenia, hemorrhage and low oral availability. Thus, the application of molecular modifications such as hybridization can produce novel, more efficient antiplatelet aggregation inhibitors. In this project we describe the synthesis and characterization of novel N-acilhydrazone compounds, acting through multiple mechanisms such as platelet calcium chelation and nitric oxide donation by furoxanic subunits. Furthermore, we demonstrate that such compounds exhibit biological activity in in vivo bleeding time, in vitro antiplatelet aggregation and in vivo antinociceptive assays. Therefore, novel N-acilhydrazone compounds demonstrate potential as antiplatelet drugs for atherothrombosis prevention.

Caracterização de estruturas de óxido de estanho modificado como sensores de gases

Pós-graduação em Química - IQ

Materiais híbridos argila-poli(metil metacrilato) obtidos através do método grafting

Pós-graduação em Química - IQ

Equipamento para realização de ensaios de tração confinada e aquecida em geossintéticos

Pós-graduação em Engenharia Civil - FEIS

Espectroscopia de impedância eletroquímica da biodissolução da calcopirita na presença de íons ferrosos

Pós-graduação em Química - IQ

Escola Pacheco e Silva anexada ao Hospital de Juqueri (1929-1940)

This article presents the results of research on the Hall-School installed in the Juqueri Hospital, São Paulo, in 1929, by initiative of the psychiatrist Antonio Carlos Pacheco e Silva, and organized by the pediatrician Vicente Baptista da Silva and professors Norberto de Souza Pinto and Celso Guimarães da Fonseca. It is regarded as a real pioneer project for the development of Special Education and of Psychology, formerly named as for the abnormals. One can neatly perceive the change in the treatment of a medical origin only to that of an inclusion of Psychology and Education in the development of children affected by mental deficiency or by psychopathies. The influence of the ideas of educators, such as the ones mentioned above, were fundamental for the changes.

A transexualidade hoje:questões para pensar o corpo e o gênero na psicanáise

Esse artigo propõe que a noção de transexualidade seja discutida a partir de vários aspectos que ela implica. O objetivo é problematizar a escuta clínica que poderia se deixar influenciar apenas pelo viés patológico, sem levar em conta o panorama atual em que a transexualidade se insere. Propomos que a transexualidade seja entendida como um conceito guarda-chuva, que abriga diferentes formas de manifestar o gênero e com variado grau de intervenção ou modificação corporal. Abordamos a rigidez dos critérios diagnósticos, a concepção de gênero, a precocidade no tratamento da transexualidade, a influência da mídia e teorizações sobre a origem da transexualidade. Destacamos o sofrimento psíquico imposto pelo campo da saúde ao estabelecer padrões de coerência entre sexo e gênero como sendo da ordem do impossível. Escutar cada pessoa transexual em sua singularidade, sem descartar a cirurgia de redesignação sexual como possível solução, nos parece ser a postura mais adequada ao trabalho psicanalítico.

Manejo das fraturas nasais com manutenção das vias aéreas superiores

Nasal fractures are extremely frequent. The nasal bones are the third most frequently fractured bones in the human skeleton. This is due to their prominent position on the face and to the diminished bone thickness. As a result, weak forces can cause nasal fractures, while stronger forces can comminute the nasal bones. In general, assaults, falls and sports injuries are the etiologies most commonly involved in nasal trauma. The diagnosis of such fractures is basically clinical and their treatment is usually by closed reduction with good results reported in all the relevant literature. Thus, the aim of this paper is to report a modification of the closed reduction technique for the treatment of these fractures.

Aspectos biológico-celulares da osseointegração baseados nas superfícies de implantes

Osseointegration involves a cascade of biological events, which can be accelerated by modifying the micro and/or nanometric topography of dental implant surfaces. Considering that different treatment types modify the titanium surface giving it a more pronounced rough topography, and physicochemical changes that appear to positively influence the osseointegration process, a literature review was made on the main types of surface treatments and their influence on the biological and cellular aspects of osseointegration, with publications dating from 1969 until the present moment. Although the precise role of the implant surface on the osseointegration of dental implants is not completely clear, the specific effects of implant surface on bone regeneration, initial kinetics, and evolution of mechanical properties have shown to be quite promising. Thus, based on dental implant surface modifications, osseointegration can be defined as a process by which rigid asymptomatic fixation of an alloplastic material can be achieved and kept in close contact with bone tissue, being resistant to early and late functional loads. This process can be modulated by an appropriate treatment of the alloplastic material surface.

Estudo do papel da proteína eIF5A na elongação da tradução em S. cerevisiae: análise da relação funcional com o trna de alanina e sua participação na síntese proteica geral da célula

Pós-graduação em Biotecnologia - IQ

Adaptação e instrumentação de um esqui ergométrico para pessoas com deficiência motora dos membros inferiores

Pós-graduação em Engenharia Elétrica - FEIS

Um estudo sobre a influência do sistema de gestão ambiental ISO 14001 sobre a imagem de organizações industriais e o papel das relações públicas

The consumers' requirements are constantly growing, as well as the concern for the environment. Considering this change of scenario, industrial companies started paying more attention to environmental issues and decided to resort to solutions such as the adoption of the Environmental Management System based on the ISO 14001 model. It is believed that the adoption of this model changes the organizational image, both internally and externally. This possible change was the focus of this research, considering that many publics related to certified companies may have the wrong idea about what being a green company really means. The objective of this study is to verify, through a survey research, the relation between the Environmental Management System based on ISO 14001 with organizational image of Brazilian firms. At first, this paper presents a theoretical review on Environmental Management System, IS0 14001, Organizational image, green Marketing, Greenwashing and Public Relations. Next, the research method is presented, as well as the results obtained through theoretical study, the research application and data analysis, and a brief analysis of the Public Relations' role in the organizational environment at issue. Finally, it presents the results obtained by tabulating the questionnaires, analysis of related data, and consideration about these

Cuidadores informais de idosos em pós-operatório de cirurgia de fêmur proximal: prevenção de novas quedas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Dysarthria and quality of life in neurologically healthy elderly and patients with Parkinson's disease

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Implementation of physiotherapeutic shares in the prevention of diabetes complications in a Family Health Strategy

Introduction In the Family Health Strategy (FHS), the treatment of Diabetes Mellitus (DM) includes education and lifestyle change strategies. Physiotherapists have a key role in this health setting. Objectives To implement actions of evaluation and guidelines for patients with type 2 DM who attend a Family Health Strategy (FHS), regarding diabetic foot and the practice of regular physical exercise in the control and prevention of the complications of Diabetes Mellitus. Methods 17 individuals from an FHS were evaluated, with the following procedures: clinical and anthropometric parameters, inspection, a questionnaire on diabetic neuropathy, tests of vibratory and tactile sensitivity, muscle function, range of motion, functional analysis, questions about exercise practice and guidance regarding controlling blood glucose and foot care. Results Deformities, dry skin, calluses, dehydration, ulceration, cracking and brittle nails were found. Peripheral neuropathy was not observed; tactile sensitivity was altered in the heel region and the vibratory sense was absent in 5% of individuals. A decrease in functionality of ankle movements was verified. Of the participants, 76% were sedentary, 24% knew about the benefits of practicing regular exercise, 25% had undergone a medical evaluation prior to performing physical exercise and, of these, 25% were supervised by a qualified professional. Discussion The implementation of physiotherapy actions in diabetics from an FHS was important for highlighting the presence of risk factors for diabetic complications. Conclusions Individuals attending the FHS need more information and programs for the prevention of diabetic complications.