A gestão do patrimônio documental arquivístico em instituições públicas: considerações sobre uma eficaz fiscalização

The purpose of this study revolves around understanding the mechanisms of control over the management of documentary heritage. Was used as a methodological procedure the theoretical research. hus, from the analysis of documentary heritage as a category of cultural heritage, was used as theoretical and methodological substantiations Federal Constitution of 1988, the Law of Archives, the Fiscal Responsibility Law, as well as texts of authors that study about the concept and management of cultural heritage in order to obtain a theoretical study on the subject treated. It was found, with the analysis of legal and scientiic texts, the absence of preventive inspection by the public administrators in relation to the documentary heritage. hus, it was realized the need for efective supervision of acts performed towards preservation and management of public documents. Based on the assumption that the “Tribunal de Contas” is the public agency responsible for enforcement of accounting standards, iscal, budgetary and environmental, it is concluded that to it also would attribute the power to enforce compliance with rules concerning the protection and management of heritage archival documents.

A extensão da racionalidade econômico-privatistica ao conhecimento produzido pela subjetividade emancipada: paradoxo da modernidade

This paper aims to present a study of the social relationships around the production, circulation and the eventual possibility of appropriation of knowledge in social systems of the pre-modern world and in a social organization of Western capitalist modernity. In this specific universe of relationships, it was also important to noticed that there is a paradoxical role of rationality that served to the emancipation of instruments of control’s knowledge of pre-modern period as in the same time it was favored by the construction of new bonds that were made in the Western modernity through the modern legal system, inserting the knowledge in the domain of the economy and private logic of the capitalist’s system through intellectual property. This research was made from a review of the literature, using specialized books of the theme. It was concluded that there is a paradox in the social relationships about the knowledge, whose cause is related to the unfolding of rationality in the development of Western civilization.

Ensino médio e ensino superior em São Paulo: notas críticas sobre o Pimesp

This article discusses the relationships between the educational levels in São Paulo, focusing in some aspects such as the integration process (higher and basic education) and the access to the public higher education institutions. Starting on analyses of those relations in the context of the educational policy of the last decades, we question the eicacy of the recent proposition named Pimesp (Program of inclusion with merit in the public higher education of São Paulo) to transform the great structural lines of these access mechanisms and integration. It is supported that programs like this, in one hand, are not new and, in the other hand, they reinforce some tendencies which are already in progress in the policies to the Brazilian higher education since 1990s. Besides that, they are not able to improve the efective conditions of the secondary public education. In the inal part we state that to face these conditions of access and the possibility of a greater integration between the levels of teaching is necessary a set of systemic educational policies, with massive public investments, long term planning, among other things that are not on the horizons of Pimesp.

Estado da arte sobre sexualidade e educação sexual: estudo analítico-descritivo de teses e dissertações produzidas na Universidade Estadual Paulista

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Citral and eugenol modulate DNA damage and pro-inflammatory mediator genes in murine peritoneal macrophages

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Mechanisms of action of fluoridated acidic liquid dentifrices against dental caries

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Interfacial integrity of low-shrinkage composite restorations related to the filling technique and consistency

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Pediatric Perioperative Cardiac Arrest and Mortality: A Study From a Tertiary Teaching Hospital

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

GPC3 reduces cell proliferation in renal carcinoma cell lines

Background: Glypican 3 (GPC3) is a member of the family of glypican heparan sulfate proteoglycans (HSPGs). The GPC3 gene may play a role in controlling cell migration, negatively regulating cell growth and inducing apoptosis. GPC3 is downregulated in several cancers, which can result in uncontrolled cell growth and can also contribute to the malignant phenotype of some tumors. The purpose of this study was to analyze the mechanism of action of the GPC3 gene in clear cell renal cell carcinoma.Methods: Five clear cell renal cell carcinoma cell lines and carcinoma samples were used to analyze GPC3 mRNA expression (qRT-PCR). Then, representative cell lines, one primary renal carcinoma (786-O) and one metastatic renal carcinoma (ACHN), were chosen to carry out functional studies. We constructed a GPC3 expression vector and transfected the renal carcinoma cell lines, 786-O and ACHN. GPC3 overexpression was analyzed using qRT-PCR and immunocytochemistry. We evaluated cell proliferation using MTT and colony formation assays. Flow cytometry was used to evaluate apoptosis and perform cell cycle analyses.Results: We observed that GPC3 is downregulated in clear cell renal cell carcinoma samples and cell lines compared with normal renal samples. GPC3 mRNA expression and protein levels in 786-O and ACHN cell lines increased after transfection with the GPC3 expression construct, and the cell proliferation rate decreased in both cell lines following overexpression of GPC3. Further, apoptosis was not induced in the renal cell carcinoma cell lines overexpressing GPC3, and there was an increase in the cell population during the G1 phase in the cell cycle.Conclusion: We suggest that the GPC3 gene reduces the rate of cell proliferation through cell cycle arrest during the G1 phase in renal cell carcinoma.

Proteomic Analysis of Gastrocnemius Muscle in Rats with Streptozotocin-Induced Diabetes and Chronically Exposed to Fluoride

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Evaluation of tensile tetention of Y-TZP crowns after long-term aging: Effect of the core substrate and crown surface conditioning

This study evaluated the effect of the core substrate type (dentin and composite resin) on the retention of crowns made of yttrium oxide stabilized tetragonal zirconia polycrystal (Y-TZP), submitted to three inner surface conditionings. For this purpose, 72 freshly extracted molars were embedded in acrylic resin, perpendicular to the long axis, and prepared for full crowns: 36 specimens had crown preparations in dentin; the remaining 36 teeth had the crowns removed, and crown preparations were reconstructed with composite resin plus fiber posts with dimensions identical to the prepared dentin. The preparations were impressed using addition silicone, and 72 Y-TZP copings for the tensile test were produced. Cementation was performed with a dual-cured cement containing phosphate monomers. For cementation, the crown preparation (dentin or resin) was conditioned with the adhesive system, and the ceramic was subjected to one of three surface treatments: isopropyl alcohol, tribochemical silica coating, or thin low-fusing glassy porcelain layer application plus silanization. After 24 hours, all specimens were submitted to thermocycling (6000 cycles) and placed in a special tensile testing device in a universal testing machine to determine failure loads. The failure modes of all samples were analyzed under a stereomicroscope. Two-way analysis of variance showed that the surface treatment and substrate type (alpha=0.05) affected the tensile retention results. The dentin substrate presented the highest tensile retention values, regardless of the surface treatment. When the substrate was resin, the tribochemical silica coating and low-fusing glaze application plus silanization groups showed the higher retention values.

PSEN1 and PSEN2 Gene Expression in Alzheimer's Disease Brain: A New Approach

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Cardiovascular and respiratory evaluation during cervical myelography using ioversol in dogs

The objective of this study was to evaluate cardiovascular and respiratory effects associated with neck flexion, subarachnoid puncture, cerebrospinal fluid drainage and the subarachnoid infusion of ioversol (320mgl/mL) in dogs under isoflurane general anesthesia. The dogs received infusion of: autologous cerebrospinal fluid at 38 degrees C (GC - control group); ioversol 0.3mL/ Kg at 25 degrees C (GI25) and heated to 38 degrees C (GI38). Heart rate, systolic and diastolic arterial pressure, respiratory rate, oxyhemoglobin saturation and electrocardiography readings were recorded. The results showed that cervical myelography with ioversol 320mgl/mL at 0.3mL/Kg (25 C-degrees and 38C degrees) did not significantly alter recorded parameters, except for an elevation in arterial pressure.