418 resultados para RECEPTORES OPIÓIDES
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Pós-graduação em Patologia - FMB
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundamento: Estresse e etanol são ambos, independentemente, importantes fatores de risco cardiovascular. Objetivo: avaliar o risco cardiovascular do consumo de etanol e exposição ao estresse, isolados e em associação, em ratos machos adultos. Métodos: Os ratos foram separados em quatro grupos: controle, etanol (20% na água de beber durante seis semanas), estresse (imobilização 1h dia/5 dias por semana/ 6 semanas) e estresse/etanol. As curvas de concentração-resposta à noradrenalina - na ausência e na presença de ioimbina, L-NAME ou indometacina - ou fenilefrina foram determinadas em aortas torácicas com e sem endotélio. EC50 e resposta máxima (n = 8-12) foram comparadas através de ANOVA de dois fatores (two-way) / método de Bonferroni. Resultados: Estresse ou estresse em associação com o consumo de etanol aumentaram as respostas máximas de noradrenalina em aortas intactas. Essa hiper-reatividade foi eliminada pela remoção do endotélio, ou pela presença da indometacina ou ioimbina, mas não foi alterada pela presença de L-NAME. Enquanto isso, o consumo de etanol não alterou a reatividade à noradrenalina. As respostas da fenilefrina em aortas com e sem endotélio também permaneceram inalteradas independentemente do protocolo. Conclusão: O estresse crônico aumentou as respostas aórticas dos ratos à noradrenalina. Esse efeito é dependente do endotélio vascular e envolve a liberação de prostanóides vasoconstritores através da estimulação de α-2 adrenoceptores endoteliais. Além disso, o consumo crônico de etanol pareceu não influenciar as respostas de noradrenalina em aorta de rato, nem modificar o aumento de tais respostas observadas em consequência da exposição ao estresse.
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The implementation of local geodetic networks for georeferencing of rural properties has become a requirement after publication of the Georeferencing Technical Standard by INCRA. According to this standard, the maximum distance of baselines to GNSS L1 receivers is of 20 km. Besides the length of the baseline, the geometry and the number of geodetic control stations are other factors to be considered in the implementation of geodetic networks. Thus, this research aimed to examine the influence of baseline lengths higher than the regulated limit of 20 km, the geometry and the number of control stations on quality of local geodetic networks for georeferencing, and also to demonstrate the importance of using specific tests to evaluate the solution of ambiguities and on the quality of the adjustment. The results indicated that the increasing number of control stations has improved the quality of the network, the geometry has not influenced on the quality and the baseline length has influenced on the quality; however, lengths higher than 20 km has not interrupted the implementation, with GPS L1 receiver, of the local geodetic network for the purpose of georeferencing. Also, the use of different statistical tests, both for the evaluation of the resolution of ambiguities and for the adjustment, have enabled greater clearness in analyzing the results, which allow that unsuitable observations may be eliminated.
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Since 2000 the use of the GPS navigation increases considerably. The reason for that was the deactivation of the selective availability in May 2000. However, these receivers do not register the observables, they just estimate and store them and that prevents the post-processing data. Based in this aspect some softwares were developed and are available for free. They allow recording the GPS observables, pseudorange and carrier phase. These programs are able to read in binary files and record information concerning the GPS observables and to convert binary format to a RINEX format. This study presents the GPS Garmin 12 XL evaluation using free programs. Two experiments were carried out in Presidente Prudente-SP region using the relative static survey. The processing was carried out with intervals of 30, 15, 10 and 5 minutes. The results were compared with the coordinates from a geodetic receiver and show that 98.9 % of the points, the values in relation to the planimetric accuracy were better than 0.50 m. The only baseline which the value was larger or equal to 0.50 m is the point M0001 (baseline lesser than 2 km) referred to the first experiment. In terms of precision the values did not exceeded 0.30 m.
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The main topic of this paper is the Ambiguity Dilution of Precision known as ADOP. Basically, ADOP is defined as a diagnostic measure for assessing the precision of the float scalar ambiguities. Among the several possibilities, the ADOP can provide help in predicting the behavior of a baseline or a network of GNSS receivers, concerning the problem of ambiguity resolution, either in real-time (instantaneous) or in the post-processing mode. The main advantage of using ADOP is possibility of the extraction of a closed analytical expression, considering various factors that affect the ambiguity resolution. Furthermore, the ADOP is related to the success rate of ambiguity resolution. The expressions here used, takes into account several factors, for example, a priori information of the measurement precision of GNSS carrier phase and pseudorange, the number of stations and satellites, the number of available frequencies and the behavior of the atmosphere (ionosphere and troposphere). Several scenarios were established so as to analyze the impact of each factor in ambiguities resolution, within the context of some stations of the São Paulo GNSS network (GNSS-SP).
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Pós-graduação em Biologia Geral e Aplicada - IBB
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Pós-graduação em Ciências Biológicas (Farmacologia) - IBB
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Pós-graduação em Ciências Biológicas (Farmacologia) - IBB
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Pós-graduação em Cirurgia Veterinária - FCAV
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Pós-graduação em Doenças Tropicais - FMB
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Pós-graduação em Química - IQ