24 resultados para representación de roles


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The most visible researchers in Knowledge Organization and Representation were identified, from the perspective of Brazilian researchers, based on cocitations from the papers presented in the last five meetings of the Encontros Nacionais de Pesquisa of the Associação Nacional de Pesquisa e Pós- Graduação em Ciência da Informação (ENANCIBs) from 2003 to 2008. First, the total number of references was identified, a total of 134 articles. Second, a citation analysis was conducted, being considered the most cited authors those who received 12 citations or more, which resulted in 31 most cited authors. Third, the Pajek software was used for the construction of the co-citation network and, thereafter, some indicators were calculated with the Ucinet software, which describe the structure and cohesion of the generated network, and, particularly, its density, and its degree of centrality, betweenness and proximity. The high cohesion of the network and the compliance between the most co-cited authors and the calculated indicators were verified.

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Paracoccidioides species are dimorphic fungi and are the etiologic agents of paracoccidioidomycosis, which is a serious disease that involves multiple organs. The many tissues colonized by this fungus suggest a variety of surface molecules involved in adhesion. A surprising finding is that most enzymes in the glycolytic pathway, tricarboxylic acid (TCA) cycle and glyoxylate cycle in Paracoccidioides spp. have adhesive properties that aid in interacting with the host extracellular matrix and thus act as 'moonlighting'proteins. Moonlighting proteins have multiple functions, which adds a dimension to cellular complexity and benefit cells in several ways. This phenomenon occurs in both eukaryotes and prokaryotes. For example, moonlighting proteins from the glycolytic pathway or TCA cycle can play a role in bacterial pathogenesis by either acting as proteins secreted in a conventional pathway and/or as cell surface components that facilitate adhesion or adherence. This review outlines the multifunctionality exhibited by many Paracoccidioides spp. enzymes, including aconitase, aldolase, glyceraldehyde-3-phosphate dehydrogenase, isocitratelyase, malatesynthase, triose phosphate isomerase, fumarase, and enolase. We discuss the roles that moonlighting activities play in the virulence characteristics of this fungus and several other human pathogens during their interactions with the host.

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Conselho Nacional de Desenvolvimento Científico e Tecnologico (CNPq)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)