Comprimidos de HPMC contendo nimesulida: preparação, caracterização e estudo dos mecanismos que regem a liberação do fármaco

The pharmaceutical innovations, such as the use of polymers to control drug release, create possibilities for a better action of the drug in the body, which causes a a more effective therapeutic effect and a safer treatment for the patient. In this work, were prepared and characterized matrix tablets of hydroxypropylmethylcellulose (HPMC) containing nimesulide as model drug to evaluate the performance as a controlled release system. HPMC, a cellulose ester, is a hydrophilic polymer that undergoes swelling, i.e., absorbs water and forms a gel layer controlling drug release. The characterization of powders was performed by analysis of particle size and morphology, density, compressibility index determination, flow properties and determination of swelling profile. The tablets were evaluated according to their physical parameters of quality and to the in vitro release of nimesulide, as well as the analysis of the mechanisms of drug release by appropriate mathematical models. The set of results showed that the HPMC/Nimesulide mixture exhibited satisfactory physical characteristics (size, shape, density and flow). The release profile demonstrated an effective control upon drug release in enteric environment and presented more correlation with Korsmeyer-Peppas’ and Weibull’s mathematical models, indicating that the release of nimesulide occurs through the relaxation of the polymer chains

Diagnóstico ambiental do Córrego Bandeirantes, município de Rio Claro, SP: parâmetros biológicos e metais-traço

This study was conducted to verify water quality and environmental impacts related to the occupation of the watershed of the Bandeirantes stream, located in Rio Claro, SP. The intention is to propose measures to enable the mitigation of negative impacts, and boosting the recovery and maintenance of the quality of water resources, preventing its complete degradation. Water analysis were performed at three different points, east, crossing the Ring Road (dirt road) and near the confluence with the Ribeirão Claro. The results indicated significant degradation of water, especially after the crossing, where it witnessed the accumulation of solid waste and easy access to the stream, both for animals as for people, due to limited riparian it. Another impact was observed the current construction of the Forum of Rio Claro in the right side of the stream studied, causing change in the landscape, change the flow properties and removal of existing vegetation at the site of work, defined as an environmentally protected area, as determined by existing law. Measures such as: restoration of riparian zones, effluent treatment, planned urban growth and environmental education of the population, would be essential to mitigate the environmental impacts of watershed Bandeirantes stream

Aplicação de princípios do pensamento enxuto no processo de envio e devolução de correspondências em um banco privado

The success obtained by the Toyota Company in implementing the Toyota Production System was a global case of study that generated different new approaches, such as Lean Thinking. This approach was already successfully applied to various sectors, breeding methodologies as Lean Service, Lean Office or Lean IT. In this paper, the main concepts of Lean Thinking were applied in an information flow through an action research, more specifically in the sending and return of mailing process from a bank. The objectives were to create changes that led to the decrease of the mail returning indexes and ultimately to cost reduction and waste elimination. For this purpose the actual situation was mapped, and after data collection and analysis, a future proposed state was generated for the information flow. Alongside, indicators were conceived for managing process control and a set of implemented and proposed improvements were delivered. The applied Lean Thinking concepts were considered efficient for the application, and the proposed objectives were achieved

Gestão de imagens em movimento de matérias jornalísticas em banco de dados na TV Digital

Pós-graduação em Televisão Digital: Informação e Conhecimento - FAAC

Comparative analysis of different meat traceability systems using multiple criteria and a social network approach

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Número Irracionais e transcendentes

Pós-graduação em Matemática - IBILCE

Meio ambiente e desenvolvimento: a construção do debate ambiental em O Correio da UNESCO (1972-1992)

Pós-graduação em História - FCLAS

Fluxo e tecnologias de informação no contexto brasileiro de inventário de ciclo de vida

Pós-graduação em Ciência da Informação - FFC

O papel da comunicação no processo de transferência de tecnologia da Embrapa para a comunidade indígena Campo Alegre de Boa Vista, RR

Pós-graduação em Comunicação - FAAC

Comunicação pública e acesso à informação: análise da atuação da SABESP em plataformas virtuais

This undergraduate research final paper analyzed the communication process carried out by the São Paulo State Water and Sanitation Company - Sabesp from the perspective of public communication, social capital and right to information theories. By monitoring Sabesp's institutional fanpage and website from 24 to 30 August 2015, it sought to assess the performance of Sabesp in disclosing public information on the context of the water supply crisis in São Paulo, concerning the fulfillment of requirements of the Right to Information Law (12.527/2011) and the need for interaction and dialogue between the institution and its stakeholders, taken as principles of public communication. The results suggest that digital media can enhance information flow and contribute to foster public relations and civic participation, but there are opportunities for Sabesp to improve communication and reach greater transparency

A gestão do fluxo das informações contábeis-financeiras como subsídio do processo de decisão: estudo de caso em uma instituição de ensino superior do terceiro setor

Pós-graduação em Ciência da Informação - FFC

O atraso na retroalimentação auditiva e seus efeitos nas disfluências típicas da gagueira

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Projeto de adaptação do sistema de injeção do túnel transônico para ensaios em bocais de foguete

In this work, the project of a new experimental facility to be installed at the Aerodynamics Division of the Institute of Aeronautics and Space is presented. This new facility will provide means to perform experimental campaigns to analyze the flow behavior at different rocket nozzle concepts using cold gas that will be obtained from a modification of the Pilot Transonic Wind Tunnel air system. The new installation will enable less expensive experiments in a more secure environment, since the cold gas experimental procedures do not demand fuel storage and burn and security procedures are much less severe. Furthermore, experiments can be carried with different types of sensors, commonly used in wind tunnel tests. Also, the optical access is facilitated enabling the use of optical techniques for the characterization of flow properties inside the nozzles, such as pressure and temperature sensitive painting. The full project design and the operation conditions will be showed, as also some technical considerations about the flor behavior in the facility

A criança nativa digital no contexto de filmes publicitários

Pós-graduação em Psicologia - FCLAS

Physicothermal properties of aqueous sodium chloride solutions

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)