Optical density of bone repair after implantation of homogenous demineralized dentin matrix in diabetic rabbits

This research evaluated the bone repair process after implantation of homogenous demineralized dentin matrix (HDDM) in surgical defects in the parietal bone of rabbits with alloxan-induced diabetes, using a polytetrafluorethylene (PTFe) barrier for guided bone regeneration. Thirty-six rabbits were used and divided into four groups: control (C, n = 12), diabetic (D, n = 12, left parietal bone), diabetic with PTFe (DPTFe, same 12 rabbits, right parietal bone), and diabetic with PTFe associated to HDDM (D-PTFe+HDDM, n = 12). Bone defects were created in the parietal bone of the rabbits and the experimental treatments were performed, where applicable. The rabbits were sacrificed after 15, 30, 60 and 90 days. The bone defects were examined radiographically and by optical density (ANOVA and Tukey test, p < .05). The radiographic findings showed that the D-PTFe+HDDM group presented greater radiopacity and better trabecular bone arrangement when compared to that of the C, D and D-PTFe groups. The statistical analysis showed significant differences in the optical density of the newly formed bone among the studied groups. It was possible to conclude that HDDM was biocompatible in diabetic rabbits.

Efeito do comprimento e da polaridade do espa��ador entre cadeias do pept��deo Hylina-C na forma dim��rica

Coordena����o de Aperfei��oamento de Pessoal de N��vel Superior (CAPES)

Express��o de fator de crescimento semelhante �� insulina (IGF-1), alvo da rapamicina em mam��feros (M-TOR), fator de c��lula tronco (SCF) e receptor C-KIT (CD117) em mastocitomas cut��nios caninos em l��minas de arranjo de matriz tecidual (TMA)

Coordena����o de Aperfei��oamento de Pessoal de N��vel Superior (CAPES)

Complementa����o do seq��enciamento do genoma do Southern bean mosaic virus, isolado S��o Paulo, express��o da por����o C-terminal da polimerase e produ����o de anti-soro policlonal

Coordena����o de Aperfei��oamento de Pessoal de N��vel Superior (CAPES)

An��lise comparativa da varia����o entre quasiespecies do V��rus da Hepatite C gen��tipo 1 em amostras pr��tratamento de pacientes tratados com Peginterferon

P��s-gradua����o em Gen��tica - IBILCE

Efeito do estado nutricional na resposta imunol��gica de camundongos BALB/c inoculados com Lacazia loboi

Coordena����o de Aperfei��oamento de Pessoal de N��vel Superior (CAPES)

Efici��ncia reprodutiva de camundongos endog��micos balb/c em diferentes idades de acasalamento, com ou sem enriquecimento ambiental

P��s-gradua����o em Zootecnia - FMVZ

An��lise da preval��ncia e de fatores de risco para as hepatites virais cr��nicas B e C em idosos residentes no munic��pio de Botucatu-SP

P��s-gradua����o em Fisiopatologia em Cl��nica M��dica - FMB

Influ��ncia do tratamento dentin��rio com Clorexidina, ��cido Hialur��nico ou Vitamina C na resist��ncia adesiva e propriedades mec��nicas da camada h��brida

P��s-gradua����o em Odontologia Restauradora - ICT

Estudo in vitro do efeito da interfer��ncia por RNA (RNAi) na replica����o do v��rus da hepatite C

Funda����o de Amparo �� Pesquisa do Estado de S��o Paulo (FAPESP)

Inibi����o do v��rus da hepatite C utilizando siRNAs direcionados para o genoma viral e prote��nas celulares Hsps

P��s-gradua����o em Microbiologia - IBILCE

Perfil imunofenot��pico e n��vel de citocinas pl��sm��ticas em portadores de hepatite C cr��nica com diferentes graus de comprometimento hep��tico

P��s-gradua����o em Pesquisa e Desenvolvimento (Biotecnologia M��dica) - FMB

Intera����o da proteina e2 do v��rus da hepatite c com o receptor de ldl e cd81 presentes em c��lulas endoteliais e ativa����o da resposta inflamat��ria

Funda����o de Amparo �� Pesquisa do Estado de S��o Paulo (FAPESP)

Vertical transmission of hepatitis C virus: A tale of multiple outcomes

Globally, hepatitis C virus (HCV) infection affects approximately 130 million people and 3 million new infections occur annually. HCV is also recognized as an important cause of chronic liver disease in children. The absence of proofreading properties of the HCV RNA polymerase leads to a highly error prone replication process, allowing HCV to escape host immune response. The adaptive nature of HCV evolution dictates the outcome of the disease in many ways. Here, we investigated the molecular evolution of HCV in three unrelated children who acquired chronic HCV infection as a result of mother-to-child transmission, two of whom were also coinfected with HIV-1. The persistence of discrete HCV variants and their population structure were assessed using median joining network and Bayesian approaches. While patterns of viral evolution clearly differed between subjects, immune system dysfunction related to HIV coinfection or persistent HCV seronegativity stand as potential mechanisms to explain the lack of molecular evolution observed in these three cases. In contrast, treatment of HCV infection with PegIFN, which did not lead to sustained virologic responses in all 3 cases, was not associated with commensurate variations in the complexity of the variant spectrum. Finally, the differences in the degree of divergence suggest that the mode of transmission of the virus was not the main factor driving viral evolution. (C) 2013 Elsevier B. V. All rights reserved.

Inflammatory response of endothelial cells to hepatitis C virus recombinant envelope glycoprotein 2 protein exposure

Funda����o de Amparo �� Pesquisa do Estado de S��o Paulo (FAPESP)