Metástase cutânea de osteossarcoma em um cão: relato de caso

Relata-se neste trabalho o caso de um cão Rottweiler, macho, de três anos de idade, com diagnóstico de osteossarcoma fibroblástico em terço distal de fêmur esquerdo, associado a metástase cutânea. Ressalta-se a insólita ocorrência deste achado em cães, sendo este um fator agravante para o prognóstico desta enfermidade.

Leishmaniose cutânea acidental

Os autores relatam o 3º caso de Leishmaniose acidental em laboratório, ocorrido em aluna do curso de Biologia, que contaminou-se por ocasião da passagem de formas amastigotas de Leishmania (Viannia) braziliensis de hamster infectado para hamster são. Chamam atenção de que, apesar de usar toda proteção exigida, a aluna foi mordida pelo hamster são, havendo como conseqüência, ruptura da luva e contágio através do inóculo.

Situacao atual da quimioterapia contra a tuberculose

Actions to overcome a disease are dependant, essentially, on what is known about it. Procedures followed in the past were sometimes bizarre, but justified because of how little was known about the disease. The tuberculosis prechemotherapeutic age was somber due to the high levels of fatalities and morbidity. With the arrival of the chemotherapeutic treatment its prognosis has changed. Tuberculosis declined in the 50's and stabilized in the 80's. Nevertheless, it is back increasing alarming its numbers more than ever; probably because of some factors, among them, the public health system lack of attention and the government's policies, increasing in the migration to and from the endemic areas, development of drug multi-resistant cepa and also to the HIV infection. An universal antimycobacteria chemotherapy treatment is not accepted, maybe because of the number of drugs that are available. Modern chemotherapy, however, has an attack and a maintenance phases with the aim to eliminate the bacillus of fast and slow multiplication, respectively. The treatment period is long, when compared with other infectious diseases, that leads to the lack of compliance. In spite of the available resources in the fight against tuberculosis they seem insufficient to restrain the disease. This has forced the search for new chemotherapy alternatives to avoid strong come back of tuberculosis to the point of being called the 'white plague' well into the 21'st century.

Caracterização da população portadora de tuberculose do município de Américo Brasiliense/SP, no período de 1992 a 2002

Tuberculosis (TB) is a serious public health problem all over the world, which was recognized by the WHO in 1993 as a global emergency because of its very high incidence in the 22 countries that concentrate 80% of TB cases. One of these countries is Brazil, where TB occurrences are well-documented in major cities, but little is known of its spread in rural areas and small towns. Therefore, an epidemiological study was done on medical records of TB sufferers in the rural district and small town of Américo Brasiliense, São Paulo state, from 1992 to 2002, with the aim of improving TB prevention and treatment. The results showed that the incidence of TB peaked in the years of intense migration of rural workers, largely cane-cutters. Among these, the disease attacks mainly the men, in their productive years (20 to 40 years old). The predominant clinical form observed was pulmonary tuberculosis. The treatment abandonment rate was less than 1.8%, while the cure rate was around 90%. The disease detection rate by examination of sputum for acid-fast bacilli was around 60%.

Ocorrência de tuberculose em um hospital psiquiátrico do interior de Goiás

Objective: To investigate the prevalence of infection, disease and eventual institutional outbreak of tuberculosis in a psychiatric hospital using the PPD test, as well as testing for mycobacteria in material collected from the respiratory tree and using molecular tracking technique based on insertion sequence 6110 (IS6110). Methods: Between February and August of 2002, PPD tests were given to 74 inpatients and 31 staff members at a psychiatric hospital in the city of Rio Verde, located in the state of Goiás, Brazil. In addition, respiratory tree material collected from the inpatients was submitted to testing for Mycobacterium tuberculosis. Results: Among the patients analyzed, mycobacteria were isolated from five (6.8%): four identified as M. tuberculosis and one as M. chelonae. The M. tuberculosis isolates were sensitive to isoniazid and rifampicin, and, when submitted to the restriction fragment length polymorphism/IS6110 technique, presented unique genetic profiles, totally distinct from one another, suggesting that all of the tuberculosis cases were due to endogenous reactivation. It was not possible to characterize this group of cases as an institutional outbreak. Performing the two-step tuberculin test in the patients, the infection rates were 23% and 31%, compared with 42% among staff members, who were submitted to the one-step test. Conclusion: The results indicate a high incidence of tuberculosis infection among inpatients and hospital staff, as well as a high occurrence of the disease among inpatients.

Tuberculose e o estudo molecular da sua epidemiologia

Systems that can distinguish epidemiologically-related Mycobacterium tuberculosis strains from unrelated ones are extremely valuable. Molecular biology techniques have allowed a great deal of information to be acquired about the infectious disease tuberculosis (TB) that was very hard or impossible to obtain by conventional epidemiology. A typing method based on bacterial DNA genome differences, known as RFLP (restriction fragment length polymorphism), is widely used to discriminate strains in the epidemiologic study of TB. However, RFLP is laborious and there is a tendency to replace it by other methods. Thus, other DNA sequences have been employed as epidemiological markers, as in Spoligotyping, a fast technique based on PCR followed by differential hybridization of amplified products. The polymorphism observed among different isolates is probably the product of strain-dependent recombination. MIRU (mycobacterial interspersed repetitive unit) typing is a reproducible and fast assay, involving the generation of genotypes based on the study of 12 loci containing VNTRs (variable-number tandem repeats) in strains of the M. tuberculosis complex. It compares strains from different geographic areas and allows the movement of individual lineages to be tracked, as in RFLP. This approach enables a greater number of isolates to be analyzed, leading to the identification of a larger number of foci of transmission within the population and thus to improved ways of slowing the progress of the disease.

Histoplasmose cutânea reveladora de infecção pelo HIV

Histoplasmosis is a systemic mycosis endemic in extensive areas of the Americas. The authors report on an urban adult male patient with uncommon oral-cutaneous lesions proven to be histoplasmosis. Additional investigation revealed unnoticed HIV infection with CD4+ cell count of 7/mm3. The treatment was performed with amphotericin B, a 2065 mg total dose followed by itraconazole 200mg/daily plus antiretroviral therapy with apparent cure. Histoplasmosis is an AIDS-defining opportunistic disease process; therefore, its clinical diagnosis must drive full laboratory investigation looking for unnoted HIV-infection. © 2013 by Anais Brasileiros de Dermatologia.

Efeito de micobactéria ambiental (Mycobacterium avium) na imunidade induzida pela vacina gênica para tuberculose (pVAXhsp65)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Ocorrência da brucelose e tuberculose bovina e percepção de riscos de produtores de leite do município de Paranaíba, Mato Grosso do Sul: Gilson Luiz Piva Filho. -

Pós-graduação em Ciência Animal - FMVA

Desenvolvimento e caracterização de sistemas micro e nanoestruturados para a administração cutânea de acetato de dexametasona

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Desenvolvimento de sistemas para veiculação de vitamina C, avaliação da estabilidade química, permeação e retenção cutânea

Pós-graduação em Ciências Farmacêuticas - FCFAR

Influência da associação de filtros solares sobre a estabilidade, liberação, permeação e retenção cutânea do p-metoxicinamato de octila em formulações fotoprotetoras

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Citocinas e proteínas de fase aguda do soro como marcadores de regressão da resposta inflamatória pelo tratamento, na tuberculose pulmonar

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Efeito da vacina gênica para tuberculose(pVAXhsp65) na encefalite autoimune experiemtal

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Emprego da tomografia computadorizada na detecção de alterações das adrenais em doentes com tuberculose

Pós-graduação em Doenças Tropicais - FMB