36 resultados para Superfamily
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Pós-graduação em Fisiopatologia em Clínica Médica - FMB
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Pós-graduação em Ciências Biológicas (Biologia Celular e Molecular) - IBRC
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Pós-graduação em Biotecnologia - IQ
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Bone Morphogenetic Proteins (BMPs) are multifunctional secreted cytokines, which belong to the TGF-beta superfamily. These glycoproteins act as a disulfide-linked homo- or heterodimers, being potent regulators of bone and cartilage formation and repair, cell proliferation during embryonic development and bone homeostasis in the adult. BMPs are promising molecules for tissue engineering and bone therapy. The present review discusses this family of proteins, their structure and biological function, their therapeutic applications and drawbacks, their effects on mesenchymal stem cells differentiation, and the cell signaling pathways involved in this process. (C) 2014 Published by Elsevier Inc.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Pós-graduação em Ciências Biológicas (Genética) - IBB
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Pós-graduação em Genética e Melhoramento Animal - FCAV
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The article refers to the collective construction performed from the Multicentric Research on Humanization Training of SUS. It is about production and building consensus on different interpretations of the superfamily "expansion of the analysis capability." The methodological approach is related to the creation of analytical reports coming from four sources: Intervention Plans built at the time of training courses offered in three states (Rio Grande do Sul, Santa Catarina and São Paulo) by the institutional supporters in training.Also, there were questionnaires answered via Form-SUS by graduated supporters after four years of the course closing; data and analysis produced by supporters in focus groups and interviews, conducted as the research final stage in the three states.Thus, considering the inclusive methodological framework not only from the courses, but also the research that evaluated them, the participants (graduates from the training courses) produced data and started to play the active role of researchers/panelists because they got “surprised" by partial analyzes.Therefore, the article discusses the analysis capability of demand required by supporters before their working areas and the relationship of that capability with concepts and elements of Institutional Analysis.It was possible to highlight the inseparability between demands of emergency and the exercise of being next to another person and his/her interests. The conclusion is that the methodology proposed by the course allowed the supporters in training to stimulate and develop a critical capacity on their work.However, it is noticed that the expansion of such analytical capability often remained linked to the supporter, without the contagion of other workers in the territories.It was also possible to see that the course and political framework of PNH could equip the supporters, promoting empowerment from their analysis, which is essential to the interventions performance.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)