Método dos elementos de contorno na resolução do problema de segunda ordem em placas delgadas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Síntese e avaliação farmacológica de novos compostos híbridos úteis para tratamento das complicaçôes da anemia falciforme

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A relação entre a álgebra acadêmica e a álgebra escolar em um curso de licenciatura em matemática: concepções de alunos e professores

Pós-graduação em Educação - FCT

Estudo para determinação de uma metodologia para o ensaio de arrancamento que avalia aderência aço/concreto

This work talks about the importance of the steel adhesion to concrete, reinforced concrete structures, their testing and forms of measurement used and how the results are used in the structural design, which uses as a reference the NBR 6118 and NBR 7480. It also deals with the importance of a reliable assessment, discussing failures that the test used, NBR 7477, features in specific circumstances, as discussed under the EC-094. It also presents an initial proposal for simplified pullout test, which aims to analyze the grip on steel bars with diameter less than 10 mm, which results when used standardized testing by ABNT NBT 7477, has shown excessive variability, the main criticism of the trial today used without distinction to be established thick or thin bars. The proposal also presented methodology is in the consolidation phase, given the time and the volume of necessary tests. For this reason it is not possible to make a comparison between the values obtained and the results of the test used on the basis of the standard in force, this can only be done once the front with a continuation of this work

Considerações sobre a armadura transversal de pilares de concreto armado

There are regulations that establish conditions and enable the design of armor columns. The NBR 6118 features statements relating to the transverse reinforcement as spacing, reinforcement diameters provision in structural elements and others. However, the norm in force does not provide an explicit methodology for the design of stirrups in different situations. We do not propose even a calculation model for this equipment and provides normative considerations for maximum or minimum values of spacings and armor in diameter. It is noteworthy that the classical references also do not provide a calculation routine sizing of transverse reinforcement and only makes the checks as the normative conditions for the given data. Based on this assumption and the problems that may occur in sizing error, both for spacing and for the proposal of the stirrup diameter, this study demonstrates that armor calculation method already established in the literature and then through an intuitive tool and available develops a spreadsheet based on this calculation routine. It takes as reference the one developed by Emil Moersch (1902) and the calculation model proposed by BUFFONI E SILVA (2006). Finally the paper presents a rational design of shear reinforcement and confronts these values with some numerical examples to show its truth

Projeto estrutural de galpão metálico segundo recomendações da NBR8800

This work deals in a general way, the history and advantages of steel buildings, as well as its increasing usage in Brazil in the last century. This work also generally describes some types and its uses of metal frame. It also demonstrates the use of the NBR 8800: 2008 standard and its calculation methods through the scale out materials regulated in Brazil for an industrial warehouse project small and simple portico metal frame. Given that the construction requirements include a locational influence following the normative indications of the NBR 6123, for the winding scale out, since this effect combined with the permanent loads must be seriously evaluated due to the shape type effort about acting simultaneous axial force and bending moments obeying the limitations applied to the structure according to NBR 8800. As it has been explained the calculations that ensures mechanical stability and suggesting an analysis of the efficiency of the used materials

Design, manufacturing, and testing of a Nb3Sn coil employing Ti alloy as structural material

We describe the design, manufacturing, and testing results of a Nb3Sn superconducting coil in which TiAIV alloys were used instead of stainless steel to reduce the magnetization contribution caused by the heat treatment for the A-15 Nb-3 Sn phase formation that affects the magnetic field homogeneity. Prior to the coil manufacturing several structural materials were studied and evaluated in terms of their mechanical and magnetic properties in as-worked, welded, and heat-treated conditions. The manufacturing process employed the wind-and-react technique followed by vacuum-pressure impregnation(VPI) at 1 MPa atm. The critical steps of the manufacturing process, besides the heat treatment and impregnation, are the wire splicing and joint manufacturing in which copper posts supported by Si3N4 ceramic were used. The coil was tested with and without a background NbTi coil and the results have shown performance exceeding the design quench current confirming the successful coil construction.

Design studies of the magnetic properties of structural materials affecting the magnetic field of high-homogeneity superconducting magnets

Austenitic stainless steel presents phase changes caused by heat treatment and welding processes. Because it represents a problem in the design of high-homogeneity magnets, we have been studying the magnetic properties of Ti alloys for their use instead of stainless steel as structural material for superconducting magnet construction. In this work, we present the comparative study of the influence of magnetic properties of steel and Ti alloys on the magnetic-field homogeneity of a superconducting coil through numerical calculation using the measured magnetic properties. © 2001 Elsevier Science B.V. All rights reserved.

Control design applied to a non-ideal structural system with behavior chaotic

In this paper we study the behavior of a structure vulnerable to excessive vibrations caused by an non-ideal power source. To perform this study, the mathematical model is proposed, derive the equations of motion for a simple plane frame excited by an unbalanced rotating machine with limited power (non-ideal motor). The non-linear and non-ideal dynamics in system is demonstrated with a chaotic behavior. We use a State-Dependent Riccati Equation Control technique for regulate the chaotic behavior, in order to obtain a periodic orbit small and to decrease its amplitude. The simulation results show the identification by State-Dependent Riccati Equation Control is very effective. © 2013 Academic Publications, Ltd.

Design and implementation of wireless sensor networks for impedance-based structural health monitoring using ZigBee and Global System for Mobile Communications

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Hypertrophy and neuron loss: structural changes in sheep SCG induced by unilateral sympathectomy

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Structural bioinformatics study of EPSP synthase from Mycobacterium tuberculosis

The shikimate pathway is an attractive target for herbicides and antimicrobial agent development because it is essential in algae, higher plants, bacteria, and fungi, but absent from mammals. Homologues to enzymes in the shikimate pathway have been identified in the genome sequence of Mycobacterium tuberculosis. Among them, the EPSP synthase was proposed to be present by sequence homology. Accordingly, in order to pave the way for structural and functional efforts towards anti-mycobacterial agent development, here we describe the molecular modeling of 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase isolated from M. tuberculosis that should provide a structural framework on which the design of specific inhibitors may be based on. Significant differences in the relative orientation of the domains in the two models result in open and closed conformations. The possible relevance of this structural transition in the ligand biding is discussed. (C) 2003 Elsevier B.V. All rights reserved.

Structural bioinformatics study of PNP from Schistosoma mansoni

The parasite Schistosoma mansoni lacks the de novo pathway for purine biosynthesis and depends on salvage pathways for its purine requirements. Schistosomiasis is endemic in 76 countries and territories and amongst the parasitic diseases ranks second after malaria in terms of social and economic impact and public health importance. The PNP is an attractive target for drug design and it has been submitted to extensive structure-based design. The atomic coordinates of the complex of human PNP with inosine were used as template for starting the modeling of PNP from S. mansoni complexed with inosine. Here we describe the model for the complex SmPNP-inosine and correlate the structure with differences in the affinity for inosine presented by human and S. mansoni PNPs. (C) 2004 Elsevier B.V. All rights reserved.

Determining the structural basis for specificity of ligands using crystallographic screening

Crystallographic screening has been used to identify new inhibitors for potential target for drug development. Here, we describe the application of the crystallographic screening to assess the structural basis of specificity of ligands against a protein target. The method is efficient and results in detailed crystallographic information. The utility of the method is demonstrated in the study of the structural basis for specificity of ligands for human purine nucleoside phosphorylase (PNP). Purine nucleoside phosphorylase catalyzes the phosphorolysis of the N-ribosidic bonds of purine nucleosides and deoxynucleosides. This enzyme is a target for inhibitor development aiming at T-cell immune response modulation and has been submitted to extensive structure-based drug design. This methodology may help in the future development of a new generation of PNP inhibitors.