Environmental adaptation of the source of the subbasin of Rico Stream, Monte Alto - SP, Brazil

Este trabalho teve como principal objetivo definir padrões fotográficos que representem o uso e a ocupação do solo da cabeceira de drenagem do Córrego Rico, localizada no Município de Monte Alto, Estado de São Paulo, para fins de adequação ambiental no que tange à legislação florestal brasileira. O mapeamento foi realizado utilizando técnicas de sensoriamento remoto e interpretação visual da imagem World View, seguida da digitalização da rede de drenagem e vegetações (naturais e agrícolas) no AutoCad, com auxílio de documentos e trabalho de campo. A área de estudo apresenta uma superfície de 2.141,53 ha, e os resultados permitiram constatar que a principal cultura é a cana-de-açúcar, com 546,34 ha, seguida de pastagens, com 251,22 ha, culturas perenes, com 191,71 ha, Eucalipto, com 57,31 ha, e a cebola, com 49,52 ha da área total, confirmando o avanço dos canaviais na região. A área possui 375,04 ha de áreas de preservação permanente (APPs), e desta superfície verificou-se que apenas 72,17 ha (19,24%) encontram-se compostos por vegetação arbórea ou mata, e destas 302,87 ha precisam ser enriquecidos e reflorestados com vegetação nativa da região, de acordo com legislação vigente. Os dados de área possibilitam futuras propostas de modelos de adequação ambiental para a microbacia, de acordo com a legislação ambiental vigente.

DNA bar-coding reveals source and patterns of Thaumastocoris peregrinus invasions in South Africa and South America

Thaumastocoris peregrinus is a recently introduced invertebrate pest of non-native Eucalyptus plantations in the Southern Hemisphere. It was first reported from South Africa in 2003 and in Argentina in 2005. Since then, populations have grown explosively and it has attained an almost ubiquitous distribution over several regions in South Africa on 26 Eucalyptus species. Here we address three key questions regarding this invasion, namely whether only one species has been introduced, whether there were single or multiple introductions into South Africa and South America and what the source of the introduction might have been. To answer these questions, bar-coding using mitochondrial DNA (COI) sequence diversity was used to characterise the populations of this insect from Australia, Argentina, Brazil, South Africa and Uruguay. Analyses revealed three cryptic species in Australia, of which only T. peregrinus is represented in South Africa and South America. Thaumastocoris peregrinus populations contained eight haplotypes, with a pairwise nucleotide distance of 0.2-0.9% from seventeen locations in Australia. Three of these haplotypes are shared with populations in South America and South Africa, but the latter regions do not share haplotypes. These data, together with the current distribution of the haplotypes and the known direction of original spread in these regions, suggest that at least three distinct introductions of the insect occurred in South Africa and South America before 2005. The two most common haplotypes in Sydney, one of which was also found in Brisbane, are shared with the non-native regions. Sydney populations of T. peregrinus, which have regularly reached outbreak levels in recent years, might thus have served as source of these three distinct introductions into other regions of the Southern Hemisphere.

The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review

The modern approach to the development of new chemical entities against complex diseases, especially the neglected endemic diseases such as tuberculosis and malaria, is based on the use of defined molecular targets. Among the advantages, this approach allows (i) the search and identification of lead compounds with defined molecular mechanisms against a defined target (e.g. enzymes from defined pathways), (ii) the analysis of a great number of compounds with a favorable cost/benefit ratio, (iii) the development even in the initial stages of compounds with selective toxicity (the fundamental principle of chemotherapy), (iv) the evaluation of plant extracts as well as of pure substances. The current use of such technology, unfortunately, is concentrated in developed countries, especially in the big pharma. This fact contributes in a significant way to hamper the development of innovative new compounds to treat neglected diseases. The large biodiversity within the territory of Brazil puts the country in a strategic position to develop the rational and sustained exploration of new metabolites of therapeutic value. The extension of the country covers a wide range of climates, soil types, and altitudes, providing a unique set of selective pressures for the adaptation of plant life in these scenarios. Chemical diversity is also driven by these forces, in an attempt to best fit the plant communities to the particular abiotic stresses, fauna, and microbes that co-exist with them. Certain areas of vegetation (Amazonian Forest, Atlantic Forest, Araucaria Forest, Cerrado-Brazilian Savanna, and Caatinga) are rich in species and types of environments to be used to search for natural compounds active against tuberculosis, malaria, and chronic-degenerative diseases. The present review describes some strategies to search for natural compounds, whose choice can be based on ethnobotanical and chemotaxonomical studies, and screen for their ability to bind to immobilized drug targets and to inhibit their activities. Molecular cloning, gene knockout, protein expression and purification, N-terminal sequencing, and mass spectrometry are the methods of choice to provide homogeneous drug targets for immobilization by optimized chemical reactions. Plant extract preparations, fractionation of promising plant extracts, propagation protocols and definition of in planta studies to maximize product yield of plant species producing active compounds have to be performed to provide a continuing supply of bioactive materials. Chemical characterization of natural compounds, determination of mode of action by kinetics and other spectroscopic methods (MS, X-ray, NMR), as well as in vitro and in vivo biological assays, chemical derivatization, and structure-activity relationships have to be carried out to provide a thorough knowledge on which to base the search for natural compounds or their derivatives with biological activity.

Nonlinear Interactions in a Piezoceramic Bar Transducer Powered by a Vacuum Tube Generated by a Nonideal Source

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Programmable PFC based hybrid multipulse power rectifier for ultra clean power application

A novel hybrid three-phase rectifier is proposed. It is capable to achieve high input power factor (PF) and low total harmonic input currents distortion (THDI). The proposed hybrid high power rectifier is composed by a standard three-phase six-pulse diode rectifier (Graetz bridge) with a parallel connection of single-phase Sepic rectifiers in each three-phase rectifier leg. Such topology results in a structure capable of programming the input current waveform and providing conditions for obtaining high input power factor and low harmonic current distortion. In order to validate the proposed hybrid rectifier, this work describes its principles, with detailed operation, simulation, experimental results, and discussions on power rating of the required Sepic converters as related to the desired total harmonic current distortion. It is demonstrated that only a fraction of the output power is processed through the Sepic converters, making the proposed solution economically viable for very high power installations, with fast investment payback. Moreover, retrofitting to existing installations is also feasible since the parallel path can be easily controlled by integration with the existing dc-link. A prototype has been implemented in the laboratory and it was fully demonstrated to both operate with excellent performance and be feasibly implemented in higher power applications.

The role of Mab as a source for the mu ring of Uranus (Research Note)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A novel programmable PFC based hybrid rectifier for ultra clean power application

A novel hybrid high power rectifier capable to achieve unity power factor is proposed in this paper. Single-phase SEPIC rectifiers are associated in parallel with each leg of three-phase 6-pulse diode rectifier resulting in a programmable input current waveform structure. In this paper it is described the principles of operation of the proposed converter with detailed simulation and experimental results. For a total harmonic distortion of the input line current (THDI) less than 2% the rated power of the SEPIC rectifiers is 33%. Therefore, power rating of the SEPIC parallel converters is a fraction of the output power, on the range of 20% to 33% of the nominal output power, making the proposed solution economically viable for high power installations, with fast pay back of the investment. Moreover, retrofits to existing installations are also possible with this proposed topology, since the parallel path can be easily controlled by integration with the already existing de-link. Experimental results are presented for a 3 kW implemented prototype, in order to verify the developed analysis.

Programmable PFC based hybrid multipulse power rectifier for utility interface of power electronic converters

In this paper it is proposed a novel hybrid three-phase rectifier capable to achieve high input power factor (PF), and low total harmonic distortion in the input currents (THDI). The proposed hybrid high power rectifier is composed by a standard three-phase 6-pulses diode rectifier (Graetz bridge) with a parallel connection of single-phase Boost rectifiers in each three-phase rectifier leg. Such topology results in a structure capable of programming the input current waveform and providing conditions for obtaining high input power factor and low harmonic current distortion. In order to validate the proposed hybrid rectifier, this paper describes its principles of operation, with detailed experimental results and discussions on power rating of the required Boost converters as related to the desired total harmonic current distortion. It is demonstrated that only a fraction of the output power is processed through the Boost converters, making the proposed solution economically viable for very high power installations, with fast pay back of the investment. Moreover, retrofitting to existing installations is also feasible since the parallel path can be easily controlled by integration with the existing de-link. A prototype rated at 6 kW has been implemented in laboratory and fully demonstrated its operation, performance and feasibility to high power applications. © 2005 IEEE.

A true programmable HPF hybrid three-phase rectifier

In this paper is proposed and analyzed a digital hysteresis modulation using a FPGA (Field Programmable Gate Array) device and VHDL (Hardware Description Language), applied at a hybrid three-phase rectifier with almost unitary input power factor, composed by parallel SEPIC controlled single-phase rectifiers connected to each leg of a standard 6-pulses uncontrolled diode rectifier. The digital control allows a programmable THD (Total Harmonic Distortion) at the input currents, and it makes possible that the power rating of the switching-mode converters, connected in parallel, can be a small fraction of the total average output power, in order to obtain a compact converter, reduced input current THD and almost unitary input power factor. The proposed digital control, using a FPGA device and VHDL, offers an important flexibility for the associated control technique, in order to obtain a programmable PFC (Power Factor Correction) hybrid three-phase rectifier, in agreement with the international standards (IEC, and IEEE), which impose limits for the THD of the AC (Alternate Current) line input currents. Finally, the proposed control strategy is verified through experimental results from an implemented prototype. ©2008 IEEE.

Hardware implementation of type-2 programmable fuzzifier

The design of full programmable type-2 membership function circuit is presented in this paper. This circuit is used to implement the fuzzifier block of Type-2 Fuzzy Logic Controller chip. In this paper the type-2 fuzzy set was obtained by blurring the width of the type-1 fuzzy set. This circuit allows programming the height and the shape of the membership function. It operates in current mode, with supply voltage of 3.3V. The simulation results of interval type-2 membership function circuit have been done in CMOS 0.35μm technology using Mentor Graphics software. © 2011 IEEE.

Resonant (P+RES) controller applied to voltage source inverter with minimum DC link capacitor

Voltage source inverters use large electrolytic capacitors in order to decouple the energy between the utility and the load, keeping the DC link voltage constant. Decreasing the capacitance reduces the distortion in the inverter input current but this also affects the load with low-order harmonics and generate disturbances at the input voltage. This paper applies the P+RES controller to solve the challenge of regulating the output current by means of controlling the magnitude of the current space vector, keeping it constant thus rejecting harmonic disturbances that would otherwise propagate to the load. This work presents a discussion of the switching and control strategy. © 2011 IEEE.

Oxidative stress in sickle cell disease: An overview of erythrocyte redox metabolism and current antioxidant therapeutic strategies

Erythrocytes have an environment of continuous pro-oxidant generation due to the presence of hemoglobin (Hb), which represents an additional and quantitatively significant source of superoxide (O2 •-) generation in biological systems. To counteract oxidative stress, erythrocytes have a self-sustaining antioxidant defense system. Thus, red blood cells uniquely function to protect Hb via a selective barrier allowing gaseous and other ligand transport as well as providing antioxidant protection not only to themselves but also to other tissues and organs in the body. Sickle hemoglobin molecules suffer repeated polymerization/depolymerization generating greater amounts of reactive oxygen species, which can lead to a cyclic cascade characterized by blood cell adhesion, hemolysis, vaso-occlusion, and ischemia-reperfusion injury. In other words, sickle cell disease is intimately linked to a pathophysiologic condition of multiple sources of pro-oxidant processes with consequent chronic and systemic oxidative stress. For this reason, newer therapeutic agents that can target oxidative stress may constitute a valuable means for preventing or delaying the development of organ complications. © © 2013 Elsevier Inc. All rights reserved.

Um novo sistema de refrigeração com controle de temperatura, compressor aberto, máquina de indução trifásica com velocidade variável e correção ativa do fator de potência do estágio de entrada

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Nubbe natural products, source of molecular diversity for the design of new anticancer agents

Pós-graduação em Química - IQ

Determinants of bird species richness, endemism, and island network roles in Wallacea and the West Indies: is geography sufficient or does current and historical climate matter?

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)