Validation of analytical methodology for quantification of cefazolin sodium pharmaceutical dosage form by high performance liquid chromatography to be applied for quality control in pharmaceutical industry

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Stability-indicating LC method for the determination of cephalothin in lyophilized powder for injection

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Concepção e implementação de um serviço baseado em localização na plataforma ANDROID/GOOGLE

The mobile application proposed in this undergraduate project, classified as a Location-Based Service and named Traveller, was developed to support users of mobile phones equipped with GPS in unknown locations by providing information about weather, location of users and stores in urban areas. The mobile devices whose this project is intended are those equipped with Android. The programming language Java was selected and the Eclipse development environment was used along with the toolkit for developing Android (ADT - Android Development Tools)

Televisão digital interativa na educação: desenvolvimento de um conteúdo. complementar ao ensino

This work had as objective the development of a prototype of educational content, as an experimental process, making use of resources from Interactive Digital TV. The characteristics of interactive digital terrestrial television are presented, in the form of a media mode capable of performing as a complementary source to education. The methodology used is composed of four phases: deduction, analysis, induction and synthesis. Its conception takes as issue the expressed need stated by UNESCO to use ICT (Information and Communications Technology) towards education, as well as the possibility of applying digital television in an educational process. The content is structured in the form of a quiz, a type of question-answer game as an informal way of education for high school students. The prototype developed in this work is presented as a structural script and map, taking into account the necessary activities and routines to put it into operation in the tested environments, eclipse, virtual set-top-box and Developer Box. The practice of prototyping was carried out in NCLua, based on middleware Ginga. As a result, we concluded that Ginga offers enough support to carry out the task, providing characteristics of interaction to publish the proposed content, at the moment of the actual practice.

Aplicativo Android para aquisição de dados de um baropodômetro via Bluetooth para apoio na análise de escoliose

Pós-graduação em Engenharia Elétrica - FEIS

Desenvolvimento de uma aplicação para suporte ao t-learning

Pós-graduação em Televisão Digital: Informação e Conhecimento - FAAC

Desenvolvimento de método analítico para estudo de degradação forçada de cefalotina sódica na forma farmacêutica pó liofilizado para solução injetável

Pós-graduação em Ciências Farmacêuticas - FCFAR

Development and validation of a simple, rapid and stability-indicating high performance liquid chromatography method for quantification of norfloxacin in a pharmaceutical product

A stability-indication high performance liquid chromatographic method has been developed for the determination of norfloxacin in tablet dosage forms. Optimum separation was achieved in less than 7 minutes using Eclipse Plus Zorbax C18 Agilent, 150 mm×4.6 mm i.d., 5 μm particle size column. The analyte was resolved by using a mobile phase 5% acetic acid aqueous solution and methanol (80:20, v/v) at a flow rate 1.0 ml/min on an isocratic high performance liquid chromatographic system at a wavelength of 277 nm. Linearity, system suitability, precision, sensitivity, selectivity, specific, and robustness were established by International Conference Harmonization guidelines. For stress studies the drug was subjected to photolysis, oxidation, acid, alkaline and neutral conditions. The analytical conditions and the solvent developed provided good resolution within a short analysis time and economic advantages. The proposed method not required sophisticated and expensive instrumentation.

Validation of analytical methodology for quantification of cefazolin sodium by liquid chromatography

A reversed-phase high performance liquid chromatography method was validated for the determination of cefazolin sodium in lyophilized powder for solution for injection to be applied for quality control in pharmaceutical industry. The liquid chromatography method was conducted on a Zorbax Eclipse Plus C18 column (250 x 4.6 mm, 5 μm), maintained at room temperature. The mobile phase consisted of purified water: acetonitrile (60: 40 v/v), adjusted to pH 8 with triethylamine. The flow rate was of 0.5 mL min-1 and effluents were monitored at 270 nm. The retention time for cefazolin sodium was 3.6 min. The method proved to be linear (r2 =0.9999) over the concentration range of 30-80 µg mL-1. The selectivity of the method was proven through degradation studies. The method demonstrated satisfactory results for precision, accuracy, limits of detection and quantitation. The robustness of this method was evaluated using the Plackett–Burman fractional factorial experimental design with a matrix of 15 experiments and the statistical treatment proposed by Youden and Steiner. Finally, the proposed method could be also an advantageous option for the analysis of cefazolin sodium, contributing to improve the quality control and to assure the therapeutic efficacy

Validation of a stability-indicating HPLC method with diode array detection for the determination of beclomethasone dipropionate in aqueous suspension for nebulizer

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Development and validation of an LC-MS/MS method for quantitative analysis of mirtazapine in human plasma

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Inclusão digital no ensino de iluminação natural

The teaching/learning activities of the daylighting built environment require from the Architecture and Urbanism undergraduate student the ability to abstract the effects of daylight distributed in three-dimensional space that is being designed. Several tools and techniques can be used to facilitate the understanding of the involved phenomena, among which the computational simulation. This paper reports the digital inclusion of the daylighting teaching in the Architecture and Urbanism undergraduate course at the School of Architecture, Arts and Social Communication of Bauru (FAAC) of UNESP – Sao Paulo State University, that began in 2010. The inclusion process involved free software use, specifically the programs DIALux and SketchUp+Radiance, both with graphical output for the illuminated scenes visualization and for result analysis. The graphic model is converted from SketchUp to Radiance by a plugin and a user-friendly interface for Windows was developed to simulate the lighting. The process of digital inclusion is consolidated, with wide acceptance by students, for which computational simulation facilitates understanding of relation between daylight and built environment and helps the design process of elements for daylighting control.

Desenvolvimento de um protótipo de revista hipermidiática para tablet: um estudo experimental com a UNESP Ciência

Pós-graduação em Televisão Digital: Informação e Conhecimento - FAAC