189 resultados para Negative Binomial Regression Model (NBRM)


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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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The objective of this study was to estimate (co)variance components using random regression on B-spline functions to weight records obtained from birth to adulthood. A total of 82 064 weight records of 8145 females obtained from the data bank of the Nellore Breeding Program (PMGRN/Nellore Brazil) which started in 1987, were used. The models included direct additive and maternal genetic effects and animal and maternal permanent environmental effects as random. Contemporary group and dam age at calving (linear and quadratic effect) were included as fixed effects, and orthogonal Legendre polynomials of age (cubic regression) were considered as random covariate. The random effects were modeled using B-spline functions considering linear, quadratic and cubic polynomials for each individual segment. Residual variances were grouped in five age classes. Direct additive genetic and animal permanent environmental effects were modeled using up to seven knots (six segments). A single segment with two knots at the end points of the curve was used for the estimation of maternal genetic and maternal permanent environmental effects. A total of 15 models were studied, with the number of parameters ranging from 17 to 81. The models that used B-splines were compared with multi-trait analyses with nine weight traits and to a random regression model that used orthogonal Legendre polynomials. A model fitting quadratic B-splines, with four knots or three segments for direct additive genetic effect and animal permanent environmental effect and two knots for maternal additive genetic effect and maternal permanent environmental effect, was the most appropriate and parsimonious model to describe the covariance structure of the data. Selection for higher weight, such as at young ages, should be performed taking into account an increase in mature cow weight. Particularly, this is important in most of Nellore beef cattle production systems, where the cow herd is maintained on range conditions. There is limited modification of the growth curve of Nellore cattle with respect to the aim of selecting them for rapid growth at young ages while maintaining constant adult weight.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Random regression models have been widely used to estimate genetic parameters that influence milk production in Bos taurus breeds, and more recently in B. indicus breeds. With the aim of finding appropriate random regression model to analyze milk yield, different parametric functions were compared, applied to 20,524 test-day milk yield records of 2816 first-lactation Guzerat (B. indicus) cows in Brazilian herds. The records were analyzed by random regression models whose random effects were additive genetic, permanent environmental and residual, and whose fixed effects were contemporary group, the covariable cow age at calving (linear and quadratic effects), and the herd lactation curve. The additive genetic and permanent environmental effects were modeled by the Wilmink function, a modified Wilmink function (with the second term divided by 100), a function that combined third-order Legendre polynomials with the last term of the Wilmink function, and the Ali and Schaeffer function. The residual variances were modeled by means of 1, 4, 6, or 10 heterogeneous classes, with the exception of the last term of the Wilmink function, for which there were 1, from 0.20 to 0.33. Genetic correlations between adjacent records were high values (0.83-0.99), but they declined when the interval between the test-day records increased, and were negative between the first and last records. The model employing the Ali and Schaeffer function with six residual variance classes was the most suitable for fitting the data. © FUNPEC-RP.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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O conhecimento do modelo de distribuição espacial de pragas na cultura é fundamental para estabelecer um plano adequado de amostragem seqüencial e, assim, permitir a correta utilização das estratégias de controle e a otimização das técnicas de amostragem. Esta pesquisa objetivou estudar a distribuição espacial de lagartas de Alabama argillacea (Hübner) na cultura do algodoeiro, cultivar CNPA ITA-90. A coleta de dados ocorreu durante o ano agrícola de 1998/99 na Fazenda Itamarati Sul S.A., localizada no município de Ponta Porã, MS, em três diferentes áreas de 10.000 m² cada uma. Cada área amostral foi composta de 100 parcelas com 100 m² cada. Foi realizada semanalmente a contagem das lagartas pequenas, médias e grandes, encontradas em cinco plantas por parcela. Os índices de agregação (razão variância/média e índice de Morisita), o teste de qui-quadrado com o ajuste dos valores encontrados e esperados às distribuições teóricas de freqüência (Poisson, binomial positiva e binomial negativa), mostraram que todos os estádios das lagartas estão distribuídos de acordo com o modelo de distribuição contagiosa, ajustando-se ao padrão da Distribuição Binomial Negativa durante todo o período de infestação.

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Para implantar o manejo apropriado do curuquerê-do-algodoeiro, é necessário construir um plano de amostragem que permita estimar, de forma rápida e precisa, a densidade populacional da praga. Esta pesquisa objetivou determinar o plano de amostragem seqüencial de Alabama argillacea (Hübner) em algodoeiro, cultivar CNPA ITA-90. Os dados foram coletados no ano agrícola de 1998/99 na Fazenda Itamarati Sul S/A, localizada no município de Ponta Porã, MS, em três áreas de 10.000 m² cada. As áreas amostrais foram compostas de 100 parcelas de 100 m². O número de lagartas pequenas, médias e grandes foi determinado semanalmente em cinco plantas tomadas ao acaso por parcela. Após verificado que todos os instares das lagartas estavam distribuídos de acordo com o modelo de distribuição agregada, ajustando-se à Distribuição Binomial Negativa durante todo o período de infestação, construiu-se um plano de amostragem seqüencial de acordo com o Teste Seqüencial da Razão de Probabilidade (TSRP). Adotou-se o nível de controle de duas lagartas por planta para a construção do plano de amostragem. A análise dos dados indicou duas linhas de decisão: a superior, que representa a condição de que a adoção de um método de controle é recomendado, definida por S1= 4,8784+1,4227n; e a inferior representando que a adoção de algum método de controle não é necessário, definida por S0= -4,8784+1,4227n. A amostragem seqüencial estimou o número máximo esperado de 16 unidades amostrais para se definir a necessidade ou não do controle.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Objective: To identify potential prognostic factors for pulmonary thromboembolism (PTE), establishing a mathematical model to predict the risk for fatal PTE and nonfatal PTE.Method: the reports on 4,813 consecutive autopsies performed from 1979 to 1998 in a Brazilian tertiary referral medical school were reviewed for a retrospective study. From the medical records and autopsy reports of the 512 patients found with macroscopically and/or microscopically,documented PTE, data on demographics, underlying diseases, and probable PTE site of origin were gathered and studied by multiple logistic regression. Thereafter, the jackknife method, a statistical cross-validation technique that uses the original study patients to validate a clinical prediction rule, was performed.Results: the autopsy rate was 50.2%, and PTE prevalence was 10.6%. In 212 cases, PTE was the main cause of death (fatal PTE). The independent variables selected by the regression significance criteria that were more likely to be associated with fatal PTE were age (odds ratio [OR], 1.02; 95% confidence interval [CI], 1.00 to 1.03), trauma (OR, 8.5; 95% CI, 2.20 to 32.81), right-sided cardiac thrombi (OR, 1.96; 95% CI, 1.02 to 3.77), pelvic vein thrombi (OR, 3.46; 95% CI, 1.19 to 10.05); those most likely to be associated with nonfatal PTE were systemic arterial hypertension (OR, 0.51; 95% CI, 0.33 to 0.80), pneumonia (OR, 0.46; 95% CI, 0.30 to 0.71), and sepsis (OR, 0.16; 95% CI, 0.06 to 0.40). The results obtained from the application of the equation in the 512 cases studied using logistic regression analysis suggest the range in which logit p > 0.336 favors the occurrence of fatal PTE, logit p < - 1.142 favors nonfatal PTE, and logit P with intermediate values is not conclusive. The cross-validation prediction misclassification rate was 25.6%, meaning that the prediction equation correctly classified the majority of the cases (74.4%).Conclusions: Although the usefulness of this method in everyday medical practice needs to be confirmed by a prospective study, for the time being our results suggest that concerning prevention, diagnosis, and treatment of PTE, strict attention should be given to those patients presenting the variables that are significant in the logistic regression model.