22 resultados para Nascent Ventures


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This work aims to investigate more deeply the concept of Newsgame in order to map essencial features for this new type of media product. Based on several examples, we will analyze the different ways in which a game can behave journalistically. We shall seek the author who coined the term “newsgame”, Gonzalo Frasca, and other international authors, based or not on the first, that attempt to point out limits for these electronic games that aspire Journalism. Some models are harsh, while others are more embracing, but all are intended to achieve a new paradigm in communication that releases itself from static representation stemmed from analog media and ventures into the potential of simulation brought from the digital platform. Examples of newsgames and its theories set forth herein also include Brazilian cases, which we will try to prove to be the most laymen on the subject

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This scientific research focus on the “Estudo de Impacto de Vizinhança” (EIV, Neighborhood Impact Study), a legal instrument instituted by federal law, and regulated by municipal law, that aims to evaluate the impacts in the neighborhood caused by the implantation or expansion of ventures within the urban zone. The main objective of this research was the formulation of general guidelines for EIV elaboration. Therefore, the following steps were considered: review of the legislation and literature on the theme; assessment of existing municipal legislation about this theme; assessment of EIVs elaborated within Rio Claro (SP); elaboration of the general guidelines for EIV elaboration, which were summarized in a flowchart

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Pós-graduação em História - FCHS

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Pós-graduação em Educação - FFC

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In the early vertebrate embryo, cardiac progenitor/precursor cells (CPs) give rise to cardiac structures. Better understanding their biological character is critical to understand the heart development and to apply CPs for the clinical arena. However, our knowledge remains incomplete. With the use of single-cell expression profiling, we have now revealed rapid and dynamic changes in gene expression profiles of the embryonic CPs during the early phase after their segregation from the cardiac mesoderm. Progressively, the nascent mesodermal gene Mesp1 terminated, and Nkx2-5+/Tbx5+ population rapidly replaced the Tbx5low+ population as the expression of the cardiac genes Tbx5 and Nkx2-5 increased. At the Early Headfold stage, Tbx5-expressing CPs gradually showed a unique molecular signature with signs of cardiomyocyte differentiation. Lineage-tracing revealed a developmentally distinct characteristic of this population. They underwent progressive differentiation only towards the cardiomyocyte lineage corresponding to the first heart field rather than being maintained as a progenitor pool. More importantly, Tbx5 likely plays an important role in a transcriptional network to regulate the distinct character of the FHF via a positive feedback loop to activate the robust expression of Tbx5 in CPs. These data expands our knowledge on the behavior of CPs during the early phase of cardiac development, subsequently providing a platform for further study.