Glargine vs. NPH insulin therapy in pregnancies complicated by diabetes: An observational cohort study

Aims: The effects of glargine insulin therapy in pregnancies are not well established. We compared maternal and neonatal outcomes of women with pregestational and gestational diabetes treated with glargine or NPH insulin.Methods: A prospective cohort study was conducted analyzing outcomes from 56 women with pregestational and 82 with gestational diabetes treated with either insulin regimen.Results: Comparisons were performed among 138 women: 56 with pregestational and 82 with gestational diabetes. In relation to maternal complications, worsening of retinopathy and nephropathy, preeclampsia, micro and macroalbuminuria, and all kinds of hypoglycemia were found higher in women with pregestational diabetes NPH-treated vs. glargine-treated. In women with gestational diabetes NPH-treated, it was observed increased incidence of prepregnancy and new-onset pregnancy hypertension, micro and macroalbuminuria, as well as mild and frequent hypoglycemia, compared to glargine-treated. Among the neonatal outcomes, 1-min Apgar score <7, necessity of intensive care unit and fetal death in pregestational, while jaundice and congenital malformations in gestational diabetes, respectively, were more frequently observed in infants born to NPH-treated, compared to glargine-treated.Conclusions: Glargine use during pregnancy from preconception through delivery, showed to be safe since it is associated with decreased maternal and neonatal adverse outcomes compared with NPH insulin-treated patients. (C) 2010 Elsevier B.V. All rights reserved.

Influence of Heat Treatment and Oxygen Doping on the Mechanical Properties and Biocompatibility of Titanium-Niobium Binary Alloys

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Influence of the Substitutional Solute on the Mechanical Properties of Ti-Nb Binary Alloys for Biomedical Use

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Recovery of silver residues from dental amalgam

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Preparation and Characterization of Ti-15Mo Alloy used as Biomaterial

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Desempenho de escolares com dislexia do desenvolvimento em tarefas fonológicas e silábicas

OBJETIVO: caracterizar o desempenho em tarefas fonológicas e silábicas de escolares com dislexia do desenvolvimento e comparar estes achados com o desempenho de discentes com bom desempenho escolar. MÉTODOS: participaram do estudo 26 alunos de oito a 12 anos de idade, de ambos os sexos, de 2ª. a 4ª. séries do Ensino Fundamental municipal na cidade de Marilia-SP, divididas em GI: composto por 13 escolares com dislexia atendidos no Centro de Estudos da Educação e Saúde - CEES/UNESP e GII: composto por 13 alunos com bom desempenho acadêmico, pareados segundo sexo, idade e escolaridade com o GI. Como procedimento foi utilizada a Prova de Consciência Fonológica - Instrumento de Avaliação Seqüencial - CONFIAS. Os resultados foram analisados estatisticamente pelo Teste Mann-Whitney (comparação entre os grupos) e Teste dos Postos Sinalizados-Wilcoxon (comparação entre as variáveis). RESULTADOS: os resultados evidenciaram diferença estatisticamente significante, sugerindo melhor desempenho do GII em relação ao GI quanto às tarefas fonêmicas e silábicas. O GI apresentou diferença estatisticamente significativa nas tarefas silábicas e fonêmicas, com melhor desempenho nas primeiras. Entre os escolares do GII não houve grande diferença estatística entre tarefas silábicas, apenas entre tarefas fonêmicas. CONCLUSÃO: o estudo concluiu que escolares com dislexia do desenvolvimento apresentam dificuldades quanto à identificação de rima e produção de palavras com o som dado, apontando para um déficit em acessar os códigos e as representações fonológicas.

Dysglycemias in pregnancy: from diagnosis to treatment. Brazilian consensus statement

There is an urgent need to find consensus on screening, diagnosing and treating all degrees of DYSGLYCEMIA that may occur during pregnancies in Brazil, considering that many cases of DYSGLYCEMIA in pregnant women are currently not diagnosed, leading to maternal and fetal complications. For this reason the Brazilian Diabetes Society (SBD) and the Brazilian Federation of Gynecology and Obstetrics Societies (FEBRASGO), got together to introduce this proposal. We present here a joint consensus regarding the standardization of clinical management for pregnant women with any degree of Dysglycemia, on the basis of current information, to improve medical assistance and to avoid related complications of Dysglycemia in pregnancy to the mother and the fetus. This consensus aims to standardize the diagnosis among general practitioners, endocrinologists and obstetricians allowing the dissemination of information in basic health units, public and private services, that are responsible for screening, diagnosing and treating disglycemic pregnant patients.

Hormone profile in juvenile systemic lupus erythematosus with previous or current amenorrhea

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

O leucograma como indicador de estresse no desmame e no transporte rodoviário de bovinos da raça Nelore

Stress can cause economic losses due to lower weight gain and increased susceptibility of animal diseases. Among the events that cause stress in calves, stand out weaning and road transport, which can result in increased serum concentrations of adrenaline and / or cortisol. This study evaluated the influence of weaning and road transport on the leukogram of Nelore calves. With this purpose, 30 calves with seven to eight months of age, divided into three groups, the first being composed of lactating animals (GL), the second by weaning animals (GD) and the third by weaning animals subjected to road transport for four hours (GDT). The first day of weaning, but not in subsequent days, there were changes in GD and GDT leukogram compatible with the action of adrenaline, as significant increases counts of WBC and neutrophils (p < 0.05), without changing in the neutrophil lymphocytes ratio (NL). In the GDT, immediately after transport, but not in subsequent days, leukogram changes were (p < 0.05) compatible with the action of cortisol, as higher N: L ratio and decreased eosinophil count. It was concluded that, under the conditions of this experiment, there are changes in leukocytes on weaning and road transport related to the action of adrenaline and road transport, respectively, and that the WBC can be used as an indicator of stress in this species.

Etiologia, perfil de sensibilidade aos antimicrobianos e aspectos epidemiológicos na otite canina: estudo retrospectivo de 616 casos

A retrospective study of etiology, antimicrobial susceptibility profile and multiple drug resistance, and major epidemiological aspects were investigated in 616 cases of canine otitis. Staphylococcus beta hemolitic (26.27%), Malassezia pachydermatis (12.35%), and Pseudomonas aeruginosa (8.8%) were the most common microorganisms identified. The isolates were susceptible mainly to norfloxacin (89.62%), gentamicin (83.25%), and ofloxacin (80.16%). High occurrence of resistance of isolates was observed to neomicin (30.84%) and cephalexin (27.63%). Multiple drug resistance to three or more and five or more of antimicrobials tested was observed in 34.9% and 15.5% of isolates, respectively. The cases of canine otitis occurred predominantly in first years of age, in mixed breeds animals, at autumn season. The presence of itch, bad smell, and secretion in ear conduct were the major signs observed at clinical examination.

Effect of iron on enamel demineralization and remineralization in vitro

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

In vitro assessment of an experimental coat applied over fluoride varnishes

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Short-term in situ/ex vivo study of the anticariogenic potential of a resin-modified glass-ionomer cement associated with adhesive systems

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)