Correlation between carotenoid concentrations in serum and normal breast adipose tissue of women with benign breast tumor or breast cancer

To evaluate the relationship between carotenoid concentrations in serum and breast tissue, we measured serum carotenoid concentrations and endogenous carotenoid levels in breast adipose tissue of women with benign breast tumor (n = 46) or breast cancer (n = 44). Before extraction, serum was digested with lipase and cholesterol esterase, and breast adipose tissue was saponified. Serum and tissue carotenoids were extracted with ether/hexane and measured by using HPLC with a C30 column. Serum retinoic acid was extracted with chloroform/methanol and measured using HPLC with a C18 column. There were no significant differences in serum carotenoids [lutein, zeaxanthin, cryptoxanthin (both α- and β-), α-carotene, all-trans β-carotene, 13-cis β-carotene and lycopene], retinoids (retinol, all-trans and 13-cis retinoic acids), and α- and -γ- tocopherol concentrations between benign breast tumor patients and breast cancer patients. A substantial amount of 9-cis β- carotene was present in adipose tissue and was the only carotenoid that had a significantly lower level in benign breast tumor patients than in breast cancer patients. Correlations between carotenoid concentrations in serum and in breast adipose tissue were determined by combining the data of the two groups. Concentrations of the major serum carotenoids except cryptoxanthin showed significant correlations with breast adipose tissue carotenoid levels. When the concentrations of serum carotenoids were adjusted for serum triglycerides or LDL, correlations between serum carotenoid concentrations and breast adipose tissue carotenoid levels markedly increased, including that of cryptoxanthin (P <0.001). The strong correlation between serum carotenoid concentrations and endogenous breast adipose tissue carotenoid levels indicate that dietary intake influences adipose tissue carotenoid levels as well as serum concentrations, and that adipose tissue is a dynamic reservoir of fat-soluble nutrients.

Market-driven security-constrained transmission network expansion planning

This paper presents a Bi-level Programming (BP) approach to solve the Transmission Network Expansion Planning (TNEP) problem. The proposed model is envisaged under a market environment and considers security constraints. The upper-level of the BP problem corresponds to the transmission planner which procures the minimization of the total investment and load shedding cost. This upper-level problem is constrained by a single lower-level optimization problem which models a market clearing mechanism that includes security constraints. Results on the Garver's 6-bus and IEEE 24-bus RTS test systems are presented and discussed. Finally, some conclusions are drawn. © 2011 IEEE.

Methodology analysis of a computational tool used in electronic circuit design

This paper considers the importance of using a top-down methodology and suitable CAD tools in the development of electronic circuits. The paper presents an evaluation of the methodology used in a computational tool created to support the synthesis of digital to analog converter models by translating between different tools used in a wide variety of applications. This tool is named MS 2SV and works directly with the following two commercial tools: MATLAB/Simulink and SystemVision. Model translation of an electronic circuit is achieved by translating a mixed-signal block diagram developed in Simulink into a lower level of abstraction in VHDL-AMS and the simulation project support structure in SystemVision. The method validation was performed by analyzing the power spectral of the signal obtained by the discrete Fourier transform of a digital to analog converter simulation model. © 2011 IEEE.

Sexual differences in parental feeding effort during the nestling period of the White-headed Marsh-Tyrant (Arundinicola leucocephala)

Parental effort may influence the fitness and survivorship of adult birds and their offspring from one breeding season to the next. Although much is known about parental feeding effort in tyrant flycatchers, many species remain understudied. In this study, I examined parental feeding effort of the White-headed Marsh-Tyrant (Awndinicola leucocephala) at a pond in southeastern Brazil. I conducted 10.3 hrs of observations from two locations: a high place with all view of the whole pond, that allowed me to observe flight distances of parents hunting for prey; and from near the nest to observe frequency of visits to the nest. The female marsh-tyrant flew farther while hunting prey and made more visits to the nest than did the male. The adults (mainly the female) provided a variety of terrestrial and aquatic arthropods to the nestlings. Additionally, parents removed fecal sacs from the nest and nestlings eliminated arthropod remains from the nest, the first records of nest sanitation activities by this species. Nonexclusive hypotheses that may explain the lower level of parental care provided by the male include: higher predation risk due its more conspicuous plumage, commitment of male to territory defense, and its selfish behavior influenced by indirect genotype fitness inherited by the offspring. © The Neotropical Ornithological Society.

The effect of muscle fatigue on the last stride before stepping down a curb

The stride before landing may be important during stepping down. The aim of this study was to analyze variability of the kinematics and muscle activity in the final stride before stepping down a curb, with and without ankle and knee muscle fatigue. Ten young participants walked at self-selected speed and stepped down a height difference (10-cm) in ongoing gait. Five trials were performed before and after a muscle fatigue protocol (one day: ankle muscle fatigue, another day: knee muscle fatigue). The analysis focused on the trailing leg during the last but one and the last step on the higher level. Kinematics and muscle activity were recorded. Fatigue increased variability of foot-step horizontal distance in the last step on the higher level of the trailing limb, as well as in the first steps on the lower level for both limbs. This appeared due to an increase in the range of motion of the knee joint after both fatigue protocols. Participants additionally showed an increased ankle and hip ROM and decreased knee ROM. Our results suggest a loss of control under fatigue reflected in a higher variability of trailing and leading limb-step horizontal distances, with compensatory changes to limit fatigue effects, such as a redistribution of movement over joints. © 2012 Elsevier B.V.

Bilevel approach for optimal location and contract pricing of distributed generation in radial distribution systems using mixed-integer linear programming

In this study, a novel approach for the optimal location and contract pricing of distributed generation (DG) is presented. Such an approach is designed for a market environment in which the distribution company (DisCo) can buy energy either from the wholesale energy market or from the DG units within its network. The location and contract pricing of DG is determined by the interaction between the DisCo and the owner of the distributed generators. The DisCo intends to minimise the payments incurred in meeting the expected demand, whereas the owner of the DG intends to maximise the profits obtained from the energy sold to the DisCo. This two-agent relationship is modelled in a bilevel scheme. The upper-level optimisation is for determining the allocation and contract prices of the DG units, whereas the lower-level optimisation is for modelling the reaction of the DisCo. The bilevel programming problem is turned into an equivalent single-level mixed-integer linear optimisation problem using duality properties, which is then solved using commercially available software. Results show the robustness and efficiency of the proposed model compared with other existing models. As regards to contract pricing, the proposed approach allowed to find better solutions than those reported in previous works. © The Institution of Engineering and Technology 2013.

Efeitos do glyphosate sobre o crescimento e absorção de fósforo pela soja

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Avaliação dos efeitos citotóxicos, genotóxicos e mutagênicos de efluentes de refinaria de petróleo, por meio dos sistemas testes de Allium cepa e Oreochromis niloticus

Pós-graduação em Ciências Biológicas (Biologia Celular e Molecular) - IBRC

Compostos bioativos e atividade antioxidante em bananas (Musa sp.)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Valor prognóstico da expressão gênica e proteica do ATM, p53 e VEGF em cadelas com neoplasias mamárias

Pós-graduação em Medicina Veterinária - FCAV

Sequenciamento do RNAm codificante da hepcidina e análise de sua expressão gênica em diferentes tecidos de ovinos saudáveis

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Stress e coping em crianças hospitalizadas em situação pré-cirúrgica e stress do acompanhante: estabelecendo relações

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Influência da deficiência de taurina no coração

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Níveis de fósforo no desenvolvimento e produção de óleo essencial de Mentha piperita L. cultivada em solução nutritiva

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Relações entre a rede de drenagem e as superfícies de aplainamento no semiárido: a bacia hidrográfica do rio Bom Sucesso (Bahia)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)