Frequency of multiple endocrine neoplasia type 1 in a group of patients with pituitary adenoma: genetic study and familial screening

The purpose of this study it was to evaluate the frequency of Multiple Endocrine Neoplasia type 1 (MEN1) in patients with pituitary adenoma and to perform genetic analysis and familial screening of those individuals afflicted with MEN1. 144 patients with pituitary adenoma at Botucatu Medical School, UNESP-Univ Estadual Paulista, were assessed retrospectively for MEN1 during the years of 2005-2011. The patients were evaluated for the presence of primary hyperparathyroidism (PHP) and enteropancreatic tumors. Genetic analysis was performed for the individuals with clinically diagnosed MEN1. Thirteen patients met the diagnostic criteria for MEN1, but three individuals belong to the same family and they were considered as a single MEN1 event, revealing 7.7 % frequency of MEN1 in this patient group. Genetic analysis showed MEN1 mutations in four index cases: IVS4+1 G>A, IVS3-6 C>T, c.1547insC and a new D180A mutation. One patient did not agree to participate in the genetic study and another one was referred for follow up in other hospital. Only polymorphisms were found in the other individuals, one of which was novel. We identified a high frequency of MEN1 in pituitary adenoma patients. Since PHP is one of the most common MEN1 tumor and patients are mostly asymptomatic, we suggest that all pituitary adenoma patients have their calcium profile analyzed. © 2013 Springer Science+Business Media New York.

Spectroscopic study and thermal behavior of trivalent lanthanides and yttrium(III) chelates of EDTA using TG-DSC, FTIR, and TG-DSC coupled to FTIR

Solid-state compounds of yttrium and lanthanide chelates of ethylenediaminetetraacetic acid have been synthesized. Simultaneous thermogravimetry and differential scanning calorimetry (TG-DSC), theoretical and experimental infrared spectroscopy (FTIR), elemental analysis, complexometry and TG-DSC coupled to FTIR were used to characterize and to study the thermal decomposition of these compounds. The results provided information about the composition, dehydration, thermal stability, thermal decomposition and identification of gaseous products evolved during the thermal decomposition of these compounds. The theoretical and experimental spectroscopic data suggest the possible modes of coordination of the ligand with the lanthanum and terbium metal ions. © 2013 Akadémiai Kiadó, Budapest, Hungary.

Normative study and evaluation of age influence on Brainstem auditory evoked potentials in mixed breed dogs]

The aim of this paper was to obtain normative data of auditory evoked potentials from 34 mixed breed dogs and evaluate the age influence. The animals were divided in two groups of different ages and auditory evoked potential was performed with a 85dB stimulus intensity. Group 1 included 16 dogs between 1 and 8 years of age, and group 2 included 18 dogs with over 8 years of age. The length and head diameter were measured and there was no statistical difference between the two groups. In group 1, mean latencies of waves I, III, and V were 1.13; 2.64, and 3.45ms, and the intervals I-III, III-V, and I-V were 1.51; 0.81, and 2.32 ms, respectively. In group 2, the mean latencies of waves I, III and V were 1.15, 2.62, and 3.55ms, and the intervals I-III, III-V, and I-V were 1.47, 0.93, and 2.40ms, respectively. The latencies observed in this study were similar to previous studies conducted by other authors. It was observed that significant differences were present for wave V and intervals III-V and I-V latencies when comparing groups with different ages, consequently this characteristic must be considered during BAEP result interpretation.

A identidade nacional e a formação do espaço-nação na experiência literária da geografia de Dona Benta, de Monteiro Lobato

Pós-graduação em Educação - IBRC

Professores de matemática e a educação inclusiva: análises de memórias de formação

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Campos de luta: o processo de construção coletiva de um livro didático na educação física no ensino médio

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Planejamento de um ambiente virtual de aprendizagem baseado em interfaces dinâmicas e uma aplicação ao estudo de potência elétrica

Pós-graduação em Engenharia Elétrica - FEIS

O integralismo pliniano: autoritarismo e ordem na defesa da nação

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Jogos digitais no ensino de matemática: o desenvolvimento de um instrumento de apoio ao diagnóstico das concepções dos alunos sobre diferentes representações dos números

Pós-graduação em Educação para a Ciência - FC

Phenomenology of OCD: Lessons from a large multicenter study and implications for ICD-11

This study aimed to investigate the phenomenology of obsessive compulsive disorder (OCD), addressing specific questions about the nature of obsessions and compulsions, and to contribute to the World Health Organization's (WHO) revision of OCD diagnostic guidelines. Data from 1001 patients from the Brazilian Research Consortium on Obsessive Compulsive Spectrum Disorders were used. Patients were evaluated by trained clinicians using validated instruments, including the Dimensional Yale Brown Obsessive Compulsive Scale, the University of Sao Paulo Sensory Phenomena Scale, and the Brown Assessment of Beliefs Scale. The aims were to compare the types of sensory phenomena (SP, subjective experiences that precede or accompany compulsions) in OCD patients with and without tic disorders and to determine the frequency of mental compulsions, the co-occurrence of obsessions and compulsions, and the range of insight. SP were common in the whole sample, but patients with tic disorders were more likely to have physical sensations and urges only. Mental compulsions occurred in the majority of OCD patients. It was extremely rare for OCD patients to have obsessions without compulsions. A wide range of insight into OCD beliefs was observed, with a small subset presenting no insight. The data generated from this large sample will help practicing clinicians appreciate the full range of OCD symptoms and confirm prior studies in smaller samples the degree to which insight varies. These findings also support specific revisions to the WHO's diagnostic guidelines for OCD, such as describing sensory phenomena, mental compulsions and level of insight, so that the world-wide recognition of this disabling disorder is increased. (C) 2014 Elsevier Ltd. All rights reserved.

As TIC nos cursos de pedagogia da UNESP: análise do currículo para formação de professores

Over the years, society changes, renews and creates conditions for the use of new technological devices. The Information and Communication Technologies (ICT) to expand in our society and are used also in teaching and learning, making it necessary that the teacher knows them. This study was first to analyze the curriculum of teacher training at the campus of UNESP, specifically in relation to courses Full Degree in Education in order to understand how these courses are structured in relation to the subjects they deal with ICT. For this, we searched the literature on the main issues involving technology and teacher education, curriculum and document analysis of Pedagogy of UNESP. It was noted that only the Faculty of Education offers the campus of Bauru disciplines working technology issues centrally. From this result, the second objective of this research was to understand, through a questionnaire, the views of students of Bauru, enrolled in these disciplines, on the Distance Education. With the results of the questionnaires it was concluded that students rated as important the knowledge of technological tools, made possible by specific disciplines during their training was noted the positive contribution of a comprehensive curriculum with respect to knowledge of ICT for reflection and formation of critical thinking in teachers training

Recursos tecnológicos: uma abordagem educacional

This study aimed to analyze the use of technological resources by teachers during their daily practice, especially the computer, in public and private elementary schools in Botucatu - SP. We know that today's society, called the Information Society and Knowledge, changes the context of education, since students have access to various information a short time. For this purpose, we use literature as a methodology and data collection through the application of a questionnaire answered by 49 students in public schools, state and private network cited. The choice of the students took place because of the diversity of schools in which they live. Our intention was not to make generalizations, but knowing more about the use of technology in these contexts from the perspective of students. The choice of subject had reason for their timeliness and necessity of knowledge, thus contributing to a comprehensive education and quality. Through data analysis, was explicit the difference between public and private schools, however, student interest was unanimous by the technologies and equitably

A aplicação de tópicos de História da Química no processo de ensino e aprendizagem: dificuldades dos alunos

This research project aims to determine the main way that the inclusion of topics of history and philosophy of science education activities aimed at high school, influence the process of teaching and learning of chemistry. The subject of research will be a teacher, undergraduate student in chemistry and public school students that the teaching units developed will be applied. The literature presents a large of research indicating the need to include these topics in education and present the results of large withdrawals of original sources of the development of scientific knowledge. Despite of the large number of these works are not very common reports of application of the results of these studies on activities of the classroom, which reinforces the importance of this study

Contribuições do PIBID para a formação inicial de professores: um olhar dos licenciandos em física da Faculdade de Engenharia de Guaratinguetá

The current work aims to analyze the contributions of PIBID for initial graduation of the teachers, in view of the undergraduates of Physics Course at UNESP Guaratinguetá . A brief literature survey about the national situation of teacher education was performed, at which the main difficulties and challenges, as well as the solutions stated in place by the government to solve them, have been highlighted. A description of the historical of PIBID at UNESP, from the institutional project to reach the subproject developed by Physics Course of Guaratinguetá, was presented. To characterize the development of the subproject, it was performed a survey on the activities performed by the PIBID’s scholars, since its implementation on campus in 2010 until the end of the year 2013, in order to map the experiences lived by program participants. These data were obtained from the analysis of reports by scholars themselves, video analyzes and record of the weekly meetings held by the group, reading electronic messages exchanged on a specific group of e-mails and written evaluations by members of the program. Completing data collection, eleven scholars undergraduates of the program were interviewed, and the results were classified by topics, defined from recurrence in the interviewees speech. The global analysis of the data was based on theoretical references commonly used in research on graduation of teachers, as Nóvoa (1992), Mizukami (2005, 2006) and Gatti (2008). The results indicate that the licensed ones see in PIBID a differentiated opportunity for initial teaching graduation, for adding practical learning experiences for students of EB within the school context, and especially for creating space for reflection on their experiences with the support of more experienced teachers, committed to the training of all involved ones