Self-assembling of phenothiazine compounds investigated by small-angle X-ray scattering and electron paramagnetic resonance spectroscopy

Small-angle X-ray scattering (SAXS) and electron paramagnetic resonance (EPR) have been carried out to investigate the structure of the self-aggregates of two phenothiazine drugs, chlorpromazine (CPZ) and trifluoperazine (TFP), in aqueous solution. In the SAXS studies, drug solutions of 20 and 60 mM, at pH 4.0 and 7.0, were investigated and the best data fittings were achieved assuming several different particle form factors with a homogeneous electron density distribution in respect to the water environment. Because of the limitation of scattering intensity in the q range above 0.15 angstrom(-1), precise determination of the aggregate shape was not possible and all of the tested models for ellipsoids, cylinders, or parallelepipeds fitted the experimental data equally well. The SAXS data allows inferring, however, that CPZ molecules might self-assemble in a basis set of an orthorhombic cell, remaining as nanocrystallites in solution. Such nanocrystals are composed of a small number of unit cells (up to 10, in c-direction), with CPZ aggregation numbers of 60-80. EPR spectra of 5- and 16-doxyl stearic acids bound to the aggregates were analyzed through simulation, and the dynamic and magnetic parameters were obtained. The phenothiazine concentration in EPR experiments was in the range of 5-60 mM. Critical aggregation concentration of TFP is lower than that for CPZ, consistent with a higher hydrophobicity of TFP. At acidic pH 4.0 a significant residual motion of the nitroxide relative to the aggregate is observed, and the EPR spectra and corresponding parameters are similar to those reported for aqueous surfactant micelles. However, at pH 6.5 a significant motional restriction is observed, and the nitroxide rotational correlation times correlate very well with those estimated for the whole aggregated particle from SAXS data. This implies that the aggregate is densely packed at this pH and that the nitroxide is tightly bound to it producing a strongly immobilized EPR spectrum. Besides that, at pH 6.5 the differences in motional restriction observed between 5- and 16-DSA are small, which is different from that observed for aqueous surfactant micelles.

The omega DD vertex in a sum rule approach

The study of charmonium dissociation in heavy ion collisions is generally performed in the framework of effective Lagrangians with meson exchange. Some studies are also developed with the intention of calculate form factors and coupling constants related with charmed and light mesons. These quantifies are important in the evaluation of charmonium cross sections. In this Letter we present a calculation of the omega DD vertex that is a possible interaction vertex in some meson-exchange models spread in the literature. We used the standard method of QCD sum rules in order to obtain the vertex form factor as a function of the transferred momentum. Our results are compatible with the value of this vertex form factor (at zero momentum transfer) obtained in the vector-meson dominance model. (c) 2006 Elsevier B.V. All rights reserved.

Semiclassical particle spectrum of double sine-Gordon model

We present new theoretical results on the spectrum of the quantum field theory of the double sine-Gordon model. This non-integrable model displays different varieties of kink excitations and bound states thereof. Their mass can be obtained by using a semiclassical expression of the matrix elements of the local fields. In certain regions of the coupling-constants space the semiclassical method provides a picture which is complementary to the one of the form factor perturbation theory, since the two techniques give information about the mass of different types of excitations. In other regions the two methods are comparable, since they describe the same kind of particles. Furthermore, the semiclassical picture is particularly suited to describe the phenomenon of false vacuum decay, and it also accounts in a natural way the presence of resonance states and the occurrence of a phase transition. (C) 2004 Elsevier B.V. All rights reserved.

Semiclassical scaling functions of sine-Gordon model

We present an analytic study of the finite size effects in sine-Gordon model, based on the semi-classical quantization of an appropriate kink background defined on a cylindrical geometry. The quasi-periodic kink is realized as an elliptic function with its real period related to the size of the system. The stability equation for the small quantum fluctuations around this classical background is of Lame type and the corresponding energy eigenvalues are selected inside the allowed bands by imposing periodic boundary conditions. We derive analytical expressions for the ground state and excited states scaling functions, which provide an explicit description of the flow between the IR and UV regimes of the model. Finally, the semiclassical form factors and two-point functions of the basic field and of the energy operator are obtained, completing the semiclassical quantization of the sine-Gordon model on the cylinder. (C) 2004 Elsevier B.V. All rights reserved.

Can the meson cloud explain the nucleon strangeness?

We use a version of the meson cloud model, including the kaon and the K-* contributions, to estimate the electric and magnetic strange form factors of the nucleon. We compare our results with the recent measurements of the strange quark contribution to parity-violating asymmetries in the forward G0 electron-proton scattering experiment. We conclude that it is very important to determine experimentally the electric and magnetic strange form factors, and not only the combination G(E)(s)+eta G(M)(s), if one does really intend to understand the strangeness of the nucleon.

New physics in B-s(0) -> J/psi phi decays?

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Collective Perspective on Advances in Dyson-Schwinger Equation QCD

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

J/Psi mass shift in nuclear matter

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Spin-1 particle in the light-front approach

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Compositeness effects in the anomalous weak-magnetic moment of leptons

We investigate the effects induced by excited leptons, at the one-loop level, in the anomalous magnetic and weak-magnetic form factors of the leptons. In particular, we compute their contributions to the weak-magnetic moment of the tau lepton, which can be measured on the Z peak, and we compare it with the contributions to g(mu) - 2, measured at low energies.

Renormalization in non-relativistic quantum mechanics

The importance and usefulness of renormalization are emphasized in non-relativistic quantum mechanics. The momentum space treatment of both two-body bound state and scattering problems involving some potentials singular at the origin exhibits ultraviolet divergence. The use of renormalization techniques in these problems leads to finite converged results for both the exact and perturbative solutions. The renormalization procedure is carried out for the quantum two-body problem in different partial waves for a minimal potential possessing only the threshold behaviour and no form factors. The renormalized perturbative and exact solutions for this problem are found to be consistent with each other. The useful role of the renormalization group equations for this problem is also pointed out.

Ghost poles in the nucleon propagator in the linear sigma model approach and its role in pi N low-energy theorems

Complex mass poles, or ghost poles, are present in the Hartree-Fock solution of the Schwinger-Dyson equation for the nucleon propagator in renormalizable models with Yukawa-type meson-nucleon couplings, as shown many years ago by Brown, Puff and Wilets (BPW), These ghosts violate basic theorems of quantum field theory and their origin is related to the ultraviolet behavior of the model interactions, Recently, Krein et.al, proved that the ghosts disappear when vertex corrections are included in a self-consistent way, softening the interaction sufficiently in the ultraviolet region. In previous studies of pi N scattering using ''dressed'' nucleon propagator and bare vertices, did by Nutt and Wilets in the 70's (NW), it was found that if these poles are explicitly included, the value of the isospin-even amplitude A((+)) is satisfied within 20% at threshold. The absence of a theoretical explanation for the ghosts and the lack of chiral symmetry in these previous studies led us to re-investigate the subject using the approach of the linear sigma-model and study the interplay of low-energy theorems for pi N scattering and ghost poles. For bare interaction vertices we find that ghosts are present in this model as well and that the A((+)) value is badly described, As a first approach to remove these complex poles, we dress the vertices with phenomenological form factors and a reasonable agreement with experiment is achieved, In order to fix the two cutoff parameters, we use the A((+)) value for the chiral limit (m(pi) --> 0) and the experimental value of the isoscalar scattering length, Finally, we test our model by calculating the phase shifts for the S waves and we find a good agreement at threshold. (C) 1997 Elsevier B.V. B.V.

Quark-antiquark correlation in the pion

The electromagnetic tensor for inclusive electron scattering off the pion Wμν for momentum transfers such that q+ = 0, (q+ = q0 + q3) is shown to obey a sum-rule for the component W++. From this sum-rule, one can define the quark-antiquark correlation function in the pion, which characterizes the transverse distance distribution between the quark and antiquark in the light-front pion wave-function. Within the realistic models of the relativistic pion wave function (including instanton vacuum inspired wave function) it is shown that the value of the two-quark correlation radius (rqq̄) is near twice the pion electromagnetic radius (rπ), where rπ ≈ 2/3 fm. We also define the correlation length lcorr where the two-particle correlation have an extremum. The estimation of lcorr ≈ 0.3-0,5 fm is very close to estimations from instanton models of QCD vacuum. It is also shown that the above correlation is very sensitive to the pion light-front wave-function models. © 1997 Elsevier Science B.V.

Heavy-quark symmetries in the light of nonperturbative QCD approaches

We critically review the validity of heavy-quark spin and flavor symmetries in heavy-light decay constants, form factors and effective couplings obtained within a nonperturbative framework, the ingredients of which are all motivated by Dyson-Schwinger equations studies of QCD. Along the way, we make new predictions for two effective nonphysical couplings: gDsDK = 24.1-1.6 +2.5 and gBsBK = 33.3 -3.7 +4.0. © Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike Licence.

Ideas of four-fermion operators in hadron physics

Four-fermion operators have been utilized in the past to link the quarkexchange processes in the interaction of hadrons with the effective mesonexchange amplitudes. In this paper, we apply the similar idea of Fierz rearrangement to the electromagnetic processes and focus on the electromagnetic form factors of nucleon and electron. We explain the motivation of using four-fermion operators and discuss the advantage of this method in computing electromagnetic processes.