Duality of osculating developables of projective curves

We give a description of the dual varieties of all developables of osculating linear spaces to a projective curve in terms of the higher order dual varieties of the curve, in arbitrary characteristic. We also determine for these varieties the inseparable degrees of the projections from the conormal varieties onto their dual varieties.

Molecular hybridization: A useful tool in the design of new drug prototypes

Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hyrid compound with improved affinity and efficacy, when compared to the parent drugs. Additionally, this strategy can results in compounds presenting modified selectivity profile, different and/or dual modes of action and reduced undesired side effects. So, in this described several example of different strategies for drug design, discovery and pharmacomodulation focused on new innovative hybrid compounds presenting analgesic, anti-inflammatory, platelet anti-aggregating, anti-infections, anticancer, cardio- and neuroactive properties.

Um método previsor-corretor primal-dual de pontos interiores barreira logarítmica modificada, com estratégias de convergência global e de ajuste cúbico, para problemas de programação não-linear e não-convexa

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Um estudo sobre certos invariantes homológicos relativos duais

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Towards criterion validity in classroom language analysis: methodological constraints of metadiscourse and inter-rater agreement

This paper reports on a process to validate a revised version of a system for coding classroom discourse in foreign language lessons, a context in which the dual role of language (as content and means of communication) and the speakers' specific pedagogical aims lead to a certain degree of ambiguity in language analysis. The language used by teachers and students has been extensively studied, and a framework of concepts concerning classroom discourse well-established. Models for coding classroom language need, however, to be revised when they are applied to specific research contexts. The application and revision of an initial framework can lead to the development of earlier models, and to the re-definition of previously established categories of analysis that have to be validated. The procedures followed to validate a coding system are related here as guidelines for conducting research under similar circumstances. The advantages of using instruments that incorporate two types of data, that is, quantitative measures and qualitative information from raters' metadiscourse, are discussed, and it is suggested that such procedure can contribute to the process of validation itself, towards attaining reliability of research results, as well as indicate some constraints of the adopted research methodology.

eIF5A has a function in the cotranslational translocation of proteins into the ER

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Efeito tardio e imediato da sutura em tendão extrassinovial íntegro: estudo biomecânico em ratos

OBJETIVO: O objetivo do estudo foi avaliar o efeito, nas propriedades mecânicas, do arranjo de reparo com material de sutura, no tendão calcâneo de rato, na ausência de processo de cicatrização. MÉTODO: Foram utilizados 12 ratos machos da linhagem Wistar. Os animais foram submetidos à colocação de ponto de sutura tipo Kessler modificado no tendão calcâneo. Os sacrifícios foram realizados nos períodos imediato e com seis semanas de pós-operatório. As propriedades mecânicas estudadas foram: carga máxima, tensão na carga máxima e módulo de elasticidade. O tendão contralateral foi usado como controle. RESULTADOS: A análise estatística indicou que, em relação aos períodos estudados, os valores das propriedades mecânicas não apresentaram diferenças significativas. em relação ao controle, isto é, tendão contralateral sem sutura, os resultados demonstram que, com seis semanas de pós-operatório, houve queda dos valores do módulo de elasticidade, enquanto a carga máxima e a tensão na carga máxima não apresentaram variações significativas. CONCLUSÃO: A colocação de material de sutura em tendão extrassinovial não lesado provocou queda do módulo de elasticidade, porém não interferiu na carga máxima e na tensão na carga máxima após seis semanas de pós-operatório.

Propolis: lymphocyte proliferation and IFN-gamma production

We evaluated propolis influence on polyclonal activation of lymphocytes by concanavalin A (Con A). The in vitro experiments showed that propolis decreases splenocyte proliferation both in the absence or presence of Con A. The supression in mitogen-induced splenocyte proliferation also occurred when mice were treated intraperitoneally with propolis for 3 days. An increased of IFN-gamma production in the culture supernatants of the same cells was, observed. A dual action of propolis on lymphocyte activation was proposed: it decreases splenocyte proliferation in the presence or absence of Con A and stimulates IFN-gamma production by spleen cells. These results are important to understand the immunomodulatory action of propolis on the host's specific and non-specific immunity. (C) 2003 Elsevier B.V. Ireland Ltd. All rights reserved.

Nodulação e micorrização em Anadenanthera peregrina var. falcata em solo de cerrado autoclavado e não autoclavado

Anadenanthera peregrina var. falcata (angico-do-cerrado), uma leguminosa arbórea, forma associações simbióticas com bactérias fixadoras de nitrogênio (rizóbios) e com fungos micorrízicos arbusculares. Com o objetivo de avaliar a eficiência da inoculação de fungos micorrízicos e rizóbios no crescimento inicial de plantas de angico-do-cerrado, crescidas em solo autoclavado e em solo não autoclavado com e sem inoculação, foi desenvolvido um experimento em casa de vegetação, utilizando raízes micorrizadas de milho e uma mistura de isolados de rizóbios como inoculantes. O crescimento das plantas foi influenciado positivamente pela concomitante inoculação do fungo micorrízico e do rizóbio, tendo as plantas desse tratamento apresentado biomassa cerca de 60 % maior do que o controle no décimo mês. A inoculação de apenas um dos microssimbiontes, entretanto, não provocou diferença na produção de biomassa das plantas. A percentagem de colonização micorrízica foi significativamente mais alta e o número de nódulos maior nas raízes das plantas crescidas no solo não autoclavado, ocasionados pela população de fungos e rizóbios nativos. Nesse tratamento, houve pequeno acúmulo de matéria no xilopódio, provavelmente em virtude do dreno fotossintético por parte dos microssimbiontes, e a concentração de P na parte aérea e xilopódio dessas plantas foi cerca de 1,2 e 8 vezes maior, respectivamente, por causa da colonização micorrízica.

Generalized sine-Gordon/massive Thirring models and soliton/particle correspondences

We consider a real Lagrangian off-critical submodel describing the soliton sector of the so-called conformal affine sl(3)((1)) Toda model coupled to matter fields. The theory is treated as a constrained system in the context of Faddeev-Jackiw and the symplectic schemes. We exhibit the parent Lagrangian nature of the model from which generalizations of the sine-Gordon (GSG) or the massive Thirring (GMT) models are derivable. The dual description of the model is further emphasized by providing the relationships between bilinears of GMT spinors and relevant expressions of the GSG fields. In this way we exhibit the strong/weak coupling phases and the (generalized) soliton/particle correspondences of the model. The sl(n)((1)) case is also outlined. (C) 2002 American Institute of Physics.

Associação entre deficiências físicas e hospitalizações na população da cidade de São Paulo, Brasil

O objetivo foi verificar a associação entre presença de deficiências físicas e hospitalizações na cidade de São Paulo, Brasil. Foi realizado inquérito de saúde na cidade de São Paulo em 2008. Utilizou-se processo de amostragem probabilística, estratificada (sexo/idade) e por conglomerados em dois estágios (setores censitários e domicílios). Os dados foram coletados por entrevistas por meio de um questionário estruturado, com 21 blocos, com a maioria das questões fechadas. A análise inferencial foi realizada com o uso de razões de prevalência (RP) bruta e ajustada e intervalo de 95% de confiança (IC95%) pelo método de regressão de Poisson. O módulo survey do programa Stata 9.2 foi usado para as análises, com significância de 5%. Foram entrevistadas 2.690 pessoas, com idade média de 38,75 anos (IC95%: 37,54-39,96). A hospitalização foi associada à deficiência (auditiva, RP = 1,59; física, RP = 3,77; múltipla, RP = 3,26). As pessoas com deficiência (auditiva, física - paralisia/amputação e múltipla) relataram internações com mais frequência que aquelas sem deficiência.

Virtual simulator for mobile robots navigation systems

This paper presents the virtual environment implementation for project simulation and conception of supervision and control systems for mobile robots, that are capable to operate and adapting in different environments and conditions. This virtual system has as purpose to facilitate the development of embedded architecture systems, emphasizing the implementation of tools that allow the simulation of the kinematic conditions, dynamic and control, with real time monitoring of all important system points. For this, an open control architecture is proposal, integrating the two main techniques of robotic control implementation in the hardware level: systems microprocessors and reconfigurable hardware devices. The implemented simulator system is composed of a trajectory generating module, a kinematic and dynamic simulator module and of a analysis module of results and errors. All the kinematic and dynamic results shown during the simulation can be evaluated and visualized in graphs and tables formats, in the results analysis module, allowing an improvement in the system, minimizing the errors with the necessary adjustments optimization. For controller implementation in the embedded system, it uses the rapid prototyping, that is the technology that allows, in set with the virtual simulation environment, the development of a controller project for mobile robots. The validation and tests had been accomplish with nonholonomics mobile robots models with diferencial transmission. © 2008 IEEE.

Influência da posição e tempo de irradiação sobre a capacidade de desinfecção em forno de micro-ondas

Objective: To evaluate the variations of temperature in 2 models of domestic micro-wave ovens, single emission (F 1) and dual emission of waves (F 2), to investigate areas of higher and lower intensity of the electromagnetic field. Materials and methods: A beaker containing water (60mL, 26°C) was irradiated into each of 5 positions (front - P 1; right - P 2; posterior - P 3; left - P 4; central - P 5) within each oven (900W/ 2min). To evaluate the effectiveness of disinfection in F 2, Bacillus subtilis suspension was irradiated in each of the 5 positions for 2, 4 and 6minutes. Data were analyzed by Kruskal-Wallis and nonparametric multiple comparisons at 5% significance level. Results: 84.80°C (F 1) and 92.01°C (F 2) were mean levels of temperature. For F 1, the positions P 1, P 2, P 3 and P 5 showed similar values among them and upper than P 4, while for F 2, the positions P 1, P 2 and P 4 were similar among them and upper than P 3 and P 5. Kruskal-Wallis test found significant differences between positions and models of ovens (p<0.05). It was observed that P 2 promoted bacterial death from 4min of irradiation, while the other positions promoted disinfection at 6min of irradiation. Conclusion: The protocols of position and time specified for the various procedures in microwave ovens can be different according to the characteristics of each device due to the electromagnetic field heterogeneity. © 2011 Sociedade Portuguesa de Estomatologia e Medicina Dentária.

Dynamics and coexistence in a system with intraguild mutualism

It is a tenet of ecological theory that two competing consumers cannot stably coexist on a single limiting resource in a homogeneous environment. Many mechanisms and processes have since been evoked and studied, empirically and theoretically, to explain species coexistence and the observed biological diversity. Facilitative interactions clearly have the potential to enhance coexistence. Yet, even though mutual facilitation between species of the same guild is widely documented empirically, the subject has received very little theoretical attention. Here, we study one form of intraguild mutualism in the simplest possibly community module of one resource and two consumers. We incorporate mutualism as enhanced consumption in the presence of the other consumers. We find that intraguild mutualism can (a) significantly enhance coexistence of consumers, (b) induce cyclic dynamics, and (c) give rise to a bi-stability (a 'joint' Allee effect) and potentially catastrophic collapse of both consumer species. © 2012 Elsevier B.V.