Uma contribuição para a otimização de portfólios de séries heteroscedásticas usando projeto de experimento de misturas: uma abordagem do desirability aplicada a modelos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Os caminhos da poesia em Juan Rámon Jiménez

Pós-graduação em Letras - FCLAS

Avaliação do estado emocional associado à catalepsia causada pela administração intraperitoneal de haloperidol

Haloperidol is a dopamine receptor antagonist used to treat schizophrenia. When systemically administered in rodents, haloperidol induces catalepsy, a state of immobility very similar to that seen in Parkinson's disease. It is known that many of Parkinson's disease symptoms are dependent on the emotional state since patients are still able to respond to external triggers such as loud noise or visual signaling. Recent data highlighted the importance of glutamatergic neurotransmission in the inferior colliculus (IC) on the cataleptic state induced by haloperidol in rats. Given the importance of IC in the brain aversion system and its connections to motor pathways, and based on the clinical reports of the emotional influence on the motor aspect of Parkinson's disease, the objective of the present study was to evaluate the emotional aspect related to catalepsy induced by intraperitoneal administration of haloperidol. To this end, we analysed ultrasonic vocalizations (UVs) of 22 kHz (indicative of aversion) in rats during the tests of catalepsy, open field and contextual conditioned fear. Systemic administration of haloperidol affected the motor activity, inducing catalepsy and decreasing exploratory activity in the open field. There were no UVs of 22 kHz resulting from treatment with haloperidol in catalepsy or open field tests. In the contextual conditioned fear test, haloperidol increased freezing when administered before the test, but decreased freezing on test day when administered before training. In this same test, haloperidol decreased the UVs on the day it was administered (training or test). The catalepsy induced by systemic administration of haloperidol seems to have also affected the motor aspect of UVs. In this way, it was not possible to clarify the existence of an aversive emotional state associated haloperidol induced catalepsy

Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in rats

It has been demonstrated that, on abrupt withdrawal, patients with chronic exposure can experience a number of symptoms indicative of a dependent state. In clinical patients, the earliest to arise and most persistent signal of withdrawal from chronic benzodiazepine (Bzp) treatment is anxiety. In laboratory animals, anxiety-like effects following abrupt interruption of chronic Bzp treatment can also be reproduced. In fact, signs that oscillate from irritability to extreme fear behaviours and seizures have been described already. As anxiety remains one of the most important symptoms of Bzp withdrawal, in this study we evaluated the anxiety levels of rats withdrawn from diazepam. Also studied were the effects on the motor performance and preattentive sensory gating process of rats under diazepam chronic treatment and upon 48-h withdrawal on three animal models of anxiety, the elevated plus-maze (EPM), ultrasonic vocalizations (USV) and startle + prepulse inhibition tests. Data obtained showed an anxiolytic- and anxiogenic-like profile of the chronic intake of and withdrawal from diazepam regimen in the EPM test, 22-KHz USV and startle reflex. Diazepam chronic effects or its withdrawal were ineffective in promoting any alteration in the prepulse inhibition (PPI). However, an increase of PPI was achieved in both sucrose and diazepam pretreated rats on 48-h withdrawal, suggesting a procedural rather than a specific effect of withdrawal on sensory gating processes. It is also possible that the prepulse can function as a conditioned stimulus to informing the delivery of an aversive event, as the auditory startling-eliciting stimulus. All these findings are indicative of a sensitization of the neural substrates of aversion in diazepam withdrawn animals without concomitant changes on the processing of sensory information

A fabulosa viagem do professor Hermenegildo rumo à educação matemática: relatos de experiências profissionais. -

Pós-graduação em Educação Matemática - IGCE

Sujeitos diaspóricos e negociações identitárias: o entre-lugar em Brazil-Maru e Sonhos Bloqueados

Pós-graduação em Letras - FCLAS

Formação continuada: dialogando com os professores que atuam no ensino infantil e fundamental (Ciclo I) da rede municipal de Bauru/SP

Currently, we can observe a significant increase in the disappointment of the world population about education, which raised doubts about the current school system and resulted in a forced increase of interest in an education reconstruction. The investigation process of this research based itself in the qualitative exploratory approach, since it allows the interpretation of the reality of the investigated environment, and it is concern about the process and not the quantification of data. Five professionals who work for the prefecture in the city of Bauru participated in this study and they graduated in the third module of the continuing education of the department of physical education from UNESP/Bauru, which occur in the second semester of 2010. The purpose of the present study was to identify the reasons why teachers who work for the prefecture in the city of Bauru look for the continuing education in physical education and explore their expectations and perception about the course. Considering the analysis presented in this study, we can observe that the search for continuing education based itself in issues such as: the confusion that exists between theory and practice, where the teachers exemplifies that, after their initial education, theory was not consistent with the real needs of their pedagogical practice; the entry of students younger and younger in the infant and fundamental education; the search for contents that answer the needs of psychomotor development of children between 2 and 5 years old and, at the same time, contents for the inclusion of children with special needs; as well as political pedagogical issues. Even though the reasons presented in this research for the teachers to justify the search for the continuing education in physical education were of distinct natures, at the end we observed that the teachers had their expectations fulfilled, demonstrating that the course of continuing education can be a space of dialog...