OS produtos naturais e a química medicinal moderna

Natural products have been utilized by humans since ancient times and the relief and cure of their diseases was the first purpose for using natural products in medicine. The history of the oriental and occidental civilizations is very rich in examples of the utilization of natural products in medicine and health care. Chinese traditional medicine is one of the most important examples of how natural products can be efficient in the treatment of diseases, and it points to the importance of scientific research on natural products, concerning the discovery of new active chemical entities. The complexity, chemical diversity and biological properties of natural products always fascinated people, and during the last 200 years, this led to the discovery of important new drugs. In the last 30 years, the development of new bioassay techniques, biotechnology methods, bio-guided phytochemical studies, automated high throughput screening and high performance analytical methods, have introduced new concepts and possibilities of rational drug design and drug discovery. In this context, natural products have played an important and decisive role in the development of modern medicinal chemistry.

Regeneração natural de espécies da Mata Atlǎntica em sub-bosque de Eucalyptus saligna Smith. em uma antiga unidade de produção forestal no Parque das Neblinas, Bertioga, SP

This study aimed at characterizing the potential for natural regeneration of native vegetation in the under-story of an earlier Eucalyptus saligna Smith production stand. The study was carried out at the Parque das Neblinas, Bertioga municipality, SP, in a 45 ha third rotation stand; which had been abandoned 15 years ago for natural regeneration to occur. The sampling was done in 24 plots of 20 × 40 m. The sampled area was of 19,200 m2, with inventory made of 100% of the eucalyptus trees. All regeneration trees with a height ≥ 1.30 m and DBH ≥ 5.0 cm were measured, as well as adult individuals with DBH ≥ 5.0 cm; surveyed in two size classes. 1,417 individuals of E. saligna were measured, with a density of 738,02 individuals/ha and a basal area of 22.69 m2/ha. Among 2,763 natural regeneration individuals, 111 species belonged to 66 genera and 34 botanical families. The species represented 43.7% of the tree richness of neighboring native forest fragments. The total estimated density and the basal area were respectively 1,052.6 individuals/ha and 6.4 m2/ha of autochthonous trees with DBH ≥ 5.0 cm (Class 1); while for regeneration there were 3,864.58 individuals/ha, and 2.76 m2/ha of individuals with a height ≥ 1.30 m and DBH < 5.0 cm (Class 2). Shannon diversity (H') was 2.83 and 3.68, respectively, for Classes 1 and 2, and the corrected species richness for a 1000-individual sample (R1000) were 75.6 and 87.29 (Fisher's a index) for the same classes. The majority of the species (34.84%) was typical from the understory of wet tropical forest and had zoochoric fruit dispersal (67.57%). The results indicate that, under these conditions, a eucalyptus forest is able to provide adequate regeneration niches for native vegetation, and may represent a sink habitat for local populations.

A moderna agricultura no final do século XIX em São Paulo: algumas propostas

Esta pesquisa se insere dentro da história da agricultura no Brasil, especialmente no Estado de São Paulo, a partir da segunda metade do século XIX, início do século XX. As propostas de modernização agrícola giravam em torno de diferentes assuntos, mas sempre interligados, como: diversificação da agricultura, adubação química e natural, cultura intensiva do solo, mão de obra, povoamento e colonização, instalação de núcleos coloniais dentro dos moldes da moderna agricultura então desejada, instrução agrícola por meio de campos de experiências e demonstração, ensino agrícola para diferentes graus, a mecanização da lavoura, o que era chamado, na época, de Moderna Agricultura, em substituição ao que era considerado como agricultura rotineira ou atrasada, praticada desde o início da agricultura no Brasil.

Análisis organizacional del Partido de la Democracia Social Brasileña en el Estado de San Pablo (1988-2006)

The article represents a theoretical and methodological approach to the analysis of organizational dynamics of political parties today, based on a study of the Party of Brazilian Social Democracy (PSDB) in the State of Sao Pãulo (period between 1988 to 2006). It is hypothesized that the structure and the institutional rules of a particular party, or even their election results, are insufficient to explain the inner workings, such as the role of party organization in the electoral system. An approach that articulates the relationship patterns, election results and posts held in the party, identified the factors that explain the political capital that circulated within the party and ensured its organizational dynamics over the period analyzed.

Deputados estaduais e democracia: Valores políticos das elites parlamentares paulista e paranaense

After 20 years of reestablished democracy in Brazil, what do the state legislators think about the regime? The goal of the article is to show the views of state legislators of the Legislative Assemblies of the States of São Paulo and Paraná on democracy. For the views we use a structured and self-administered questionnaire. The results show that for the state legislators: i) democracy is stable, ii) it is superior to any other kind of regime, iii) it's support comes from some public policy and the use of voting and iv) parties and elections are important for democracy.

Acesso ao direito e a democratização da justiça na assistência jurídica integral e gratuita contemporânea

Pós-graduação em Ciências Sociais - FFC

Poder e violência: Hannah Arendt e a Nova Esquerda

Pós-graduação em Ciências Sociais - FFC

Democracia no cotidiano escolar

Pós-graduação em Educação - IBRC

Entre o formal e o real: representações acerca do modelo disciplinar da Fundação CASA de Araraquara

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Políticas neoliberais e educação pós-moderna no ensino paulista

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A dialética do conhecimento científico, a prática e a experimentação: uma análise do ideário de licenciandos e sua relação com a epistemologia da ciência moderna

Pós-graduação em Educação para a Ciência - FC

Os movimentos matemática moderna: compreensões e perspectivas a partir da análise da obra Matemática - Curso Ginasial do SMSG

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Ensaio sobre a cegueira, de José Saramago, e a experiência pós-moderna da verdade

Pós-graduação em Estudos Literários - FCLAR

Aporias da justiça: entre Habermas e Rawls

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)