Doença: sofrimento e vida nas filosofias de Friedrich Nietzsche e Blase Pascal

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Anônimas da história: relações de trabalho e atuação política de sapateiras entre as décadas de 1950 e 1980 (Franca-SP)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A metaficção e as entrelinhas em O doente Molière (2000), de Rubem Fonseca

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Espaço da circulação e saúde ambiental na produção do espaço urbano em Manaus

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Usos das vias urbanas em Presidente Prudente: espaços públicos e legislação urbana

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Análise biomecânica da marcha de mulheres com uso de sapatos com saltos em solo plano e inclinado

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Tecendo caminhos: a identidade do microempreendedor têxtil em Franca/SP

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Dos pés à cabeça: a reestruturação produtiva e a atuação das mulheres nas indústrias no município de Franca/SP

Pós-graduação em Serviço Social - FCHS

Uso do 210 Pb na cronologia da contaminação de cromo em sedimentos do Ribeirão dos Bagres, região de Franca (SP)

Pós-graduação em Geociências e Meio Ambiente - IGCE

O comércio no arranjo produtivo local calçadista de Franca (SP)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Desafios e possibilidades: a luta por (re) costurar a vida

Pós-graduação em Serviço Social - FCHS

Traceability Issues in the Trade of Marine Ornamental Species

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Análise da distribuição de força plantar e postura em diferentes alturas de salto alto por meio de uma plataforma de força simuladora de salto alto

Pós-graduação em Engenharia Mecânica - FEG

Telomere and Telomerase Biology

Telomeres are the physical ends of eukaryotic linear chromosomes. Telomeres form special structures that cap chromosome ends to prevent degradation by nucleolytic attack and to distinguish chromosome termini from DNA double-strand breaks. With few exceptions, telomeres are composed primarily of repetitive DNA associated with proteins that interact specifically with double- or single-stranded telomeric DNA or with each other, forming highly ordered and dynamic complexes involved in telomere maintenance and length regulation. In proliferative cells and unicellular organisms, telomeric DNA is replicated by the actions of telomerase, a specialized reverse transcriptase. In the absence of telomerase, some cells employ a recombination-based DNA replication pathway known as alternative lengthening of telomeres. However, mammalian somatic cells that naturally lack telomerase activity show telomere shortening with increasing age leading to cell cycle arrest and senescence. In another way, mutations or deletions of telomerase components can lead to inherited genetic disorders, and the depletion of telomeric proteins can elicit the action of distinct kinases-dependent DNA damage response, culminating in chromosomal abnormalities that are incompatible with life. In addition to the intricate network formed by the interrelationships among telomeric proteins, long noncoding RNAs that arise from subtelomeric regions, named telomeric repeat-containing RNA, are also implicated in telomerase regulation and telomere maintenance. The goal for the next years is to increase our knowledge about the mechanisms that regulate telomere homeostasis and the means by which their absence or defect can elicit telomere dysfunction, which generally results in gross genomic instability and genetic diseases.

As Praças Centrais de Presidente Prudente-SP: avaliação do caráter como subsídio para intervenções projetuais

During the process of development and urban sprawl in the city of Presidente Prudente (SP), some factors as the emergence of new centralities, the change in lifestyles and the expansion of equipments and urban infrastructure contributed to the dismantling and little appropriation of the central open space system. In this sense, the work is about the loss of continuity between the central squares of the city - Monsenhor Sarrion Square, July 9 Square, Bandeira Square and Nossa Senhora Aparecida Square - using different methodologies for character evaluation of each square, identifying the inviting and unattractive aspects of their spaces. The relations between these squares and its surroundings are characterized by analyzing interesting visual played on sketches, to complement character evaluation. Among these studies, it is also analyzed two spatial structures related to the squares – Calçadão and Quintino Bocaiuva Street - which have important architectural referring to the city's history and contribute to the central open space system configuration. General considerations obtained through diagnosis provided subsidies for the projectual proposed intervention, which aims to provide appreciation of the character of these public spaces and their articulation, promoting their use and constituting, thus, an important urban-environment set