Prevalência de trombose venosa profunda e embolia pulmonar em tromboflebite superficial de membros inferiores

Pós-graduação em Bases Gerais da Cirurgia - FMB

Do catálogo impresso ao cátalogo on-line: algumas considerações e desafios ao bibliotecário

In relation to the changes that mark the trajectory of libraries catalogs, this paper aims to describe the challenges that go beyond the current status of librarians, in relation to use of the on-line catalog as the main tool storage and retrieval of documentary information. Using literature specialized is intended to contribute to the discussion of the topic, in order to understand the challenges and prospects of using this important tool for search and information retrieval.

Geoparks in Brazil-strategy of Geoconservation and Development

Within the framework of the potential of geopark development and the interest of the geological community in creating new areas for geoconservation in Brazil, the aim of this contribution is to show the importance of geoscience education as a strategy for both geoconservation and development, and for the success and maintenance of new geoparks. A historical and evolutionary approach to the theme reveals the current status of geoscience education in Brazil and offers a panorama of the challenges inherent in preparing for the creation of new geoconservation areas. Proposals that aim to promote geoconservation and sustainability in Brazil include projects that capitalize on geological heritage and its relationship with local communities, proposals that form partnerships between the government, universities, businesses, and non-governmental organizations for the development of education, and changes in the law specifically aimed at geoconservation. Improvement in the educational system, including Earth science education, is undoubtedly one of the best strategies to promote the preservation of our natural heritage, and a cultural change in education will certainly promote changes in other areas.

Estudo sobre o entorno do mercado municipal de São Paulo

A city is a place, is a housing, is the birthing place of economics. A city is made of routes, is made of people, by people and must also be structured for people. However, with the consolidation of a neoliberal economic system where ownership and economic generation prevail over the citizen's rights and the needs of those who have less, the city becomes a space of buying, exchange and increasingly commercial. The city of São Paulo is part of this context and is the result of the transformation process driven by real estate speculation, and the presented study area, the surroundings of the Municipal Market of São Paulo, is a new area in transformation. This work has the goal to bring a historical perspective and current status of the locality, with their revitalization projects, landscape changes and changes in housing, audience and resident citizens

Cogeração em uma indústria automobilística

The search for energy efficiency improvement is a common concern in many companies. Cogeneration is a well known technique but not so spread in Brazil, despite its potential for energy costs reduction through heat recovery from prime movers. In this work, a preliminary technical and economic study is carried out for a cogeneration plant application in an automotive industry of São Paulo. Though mathematics modeling, three 2435 kW internal combustion engines are selected. When compared to the current status (no cogeneration), annual savings of about 2,2 MR$ are obtained, resulting a almost 3 years payback

Diagnóstico ambiental do município de Ipeúna: subsídios para o planejamento do turismo

This study sought to address the tourism system in its various strands, compared to socioeconomic and environmental issues. Contextualizing the theme of sustainable tourism, or ecotourism, the reality of the city of Ipeúna, there is the incipient state of efforts in this activity because, predominantly, its territory is occupied by the monoculture of cane sugar and pastures, which damages the maintenance of vegetation fragments, as well as degrading areas that often could take a value tour. Through environmental planning, was intended to raise major issues of interface tourism / environment in order to seek alternatives to the implementation and development of tourism in Ipeúna. As a result, it presents an environmental diagnosis of the study area through which to assess the current status of tourist attractions in relation to environmental and socio-economic dynamics of the city.

Planejamento ambiental da Bacia Hidrográfica do Córrego da Olga, UGRHI Pontal do Paranapanema – São Paulo: inventário e diagnóstico

This work, presented in order to obtain the environmental engeneer title, is to raise the current status of environmental conditions in the watershed of the stream of Olga and thus contribute to environmental planning for the recovery, conservation and preservation. To this end, we conducted literature surveys and survey of the characteristics of the watershed, analysis of water fron stream of Olga and making use of remote sensingand of the soil, environmental fragiityand spatialization of APPs in order to carry out further research on the environmental conditions of the basin, as well as inferences about possible causes of degradation of watershed.Most of the basin of the stream Olga had a high environmental fargility and the main problem was the lack of riparian vegetation is also considered the cause of environmental problems of the watershed.The results will be available to municipal governments in order to contribute to their planning and management of UGRHI the teh watershed pertence

Estado actual del blanqueamiento: sigue siendo un tratamiento seguro? review

The demand for cosmetic dentistry, including teeth whitening, has increased in recent years. The home teeth whitening and in-office, are widely used in dental practice. The mechanism by which it works is by oxidation of the chromogenic existing tooth structure. This is an effective and minimally invasive procedure that achieves tooth lighten the color, however, may cause alterations in the enamel surface, such as a dental permeability increase. Another effect caused by this procedure is tooth sensitivity, being the most common side effect, up to 65% of individuals have had a secondary effect at least once during treatment. This sensitivity and gingival irritation caused by bleaching may vary depending on the patient and used bleaching product

Aplicação da tecnologia 4G em projetos de telefonia

This paper presents a study based on bibliographic research on LTE technology, chosen for the fourth generation of mobile phones, and the current status of implementation of 4G network in Brazil. The change in user behavior, which now uses data over the voice services, requires transmission networks to be increasingly robust and fast to enable the viewing of videos and use of other platforms that require internet connection. The retrospective of the development of mobile technologies, from 1G up to 4G that is currently used, shows the long road until it came to appliances and how the phone is used nowadays. Finally, the popularity of smartphones and hence the growing number of people with access to 4G networks, demanded new researchs for the development of future generations technologies in order to achieve the demand for speed enabling significant changes in user experience

Expression of genes related to apoptosis, cell cycle and signaling pathways are independent of TP53 status in urinary bladder cancer cells

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Chromogenic in situ hybridization compared with other approaches to evaluate HER2/neu status in breast carcinomas

Human epidermal growth factor receptor 2 (HER2) has been evaluated in breast cancer patients to identify those most likely to benefit from herceptin-targeted therapy. HER2 amplification, detected in 20-30% of invasive breast tumors, is associated with reduced survival and metastasis. The most frequently used technique for evaluating HER2 protein status as a routine procedure is immunohistochemistry (IHC). HER2 copy number alterations have also been evaluated by fluorescence in situ hybridization (FISH) in moderate immunoexpression (IHC 2+) cases. An alternative procedure to evaluate gene amplification is chromogenic in situ hybridization (CISH), which has some advantages over FISH, including the correlation between HER2 status and morphological features. Other methodologies have also been used, such as silver-enhanced in situ hybridization (SISH) and quantitative real-time RT-PCR, to determine the number of HER2 gene copies and expression, respectively. Here we will present a short and comprehensive review of the current advances concerning HER2 evaluation in human breast cancer.

Grade of esophageal cancer and nutritional status impact on postsurgery outcomes

CONTEXTO: A desnutrição protéico-energética constitui causa previsível para o desenvolvimento de complicações pós-operatórias e pior prognóstico de pacientes cirúrgicos. OBJETIVO: Estudar a associação de indicadores de estado nutricional com estádio da doença e as principais complicações e mortalidade pós-operatória de pacientes com câncer de esôfago. MÉTODO: Foram avaliados retrospectivamente 100 prontuários de pacientes com câncer de esôfago (38-81 anos) de ambos os sexos (85% masculino e 15% feminino) submetidos a esofagectomia (n = 25) e gastrojejunostomia (n = 75), no período de 1995 a 2004. Os dados coletados foram: história clínica, exame endoscópico, estádio (TNM-UICC), estado nutricional (índice de massa corporal, percentual de perda de peso - %PP, albuminemia e contagem de linfócitos total) e evolução clínica pós-operatória. Houve composição dos grupos de acordo com o porte da cirurgia (grande x pequeno). Foi realizada a associação entre as complicações pós-operatórias e a mortalidade (após pós-operatório de 30 dias). As comparações entre médias dos dois grupos foram feitas pelo teste t de Student e a existência de associações entre variáveis testadas pelos testes de χ2 ou exato de Fisher com P = 0,05. RESULTADOS: Houve predomínio dos tumores avançados (estádio III e IV), com a presença de disfagia em 95% dos pacientes e perda ponderal >10%, anterior ao diagnóstico, em 78%. A obstrução esofágica, presente em 77 pacientes, foi associada (P = 0,0021) com o baixo índice de massa corporal (desnutrição protéico-energética). A %PP e a hipoalbuminemia associaram-se estatisticamente (P<0,05) com o estádio avançado da doença. As complicações pós-operatórias precoces ocorreram em 69,2% e 30,7% dos pacientes submetidos a esofagectomia e ostomias, respectivamente, com predomínio das infecciosas nas ostomias (80%) e as pleuropulmonares nas esofagectomias (61%). A albuminemia foi menor nos pacientes submetidos as ostomias, tendo sido a hipoalbuminemia associada (P<0,05) com a ocorrência de complicações pós-operatórias e mortalidade. A %PP e a contagem de linfócitos total associaram-se com as complicações pós-operatórias precoces e infeccionas nas ostomias e a contagem de linfócitos total, com a mortalidade operatória nas esofagectomias. CONCLUSÕES: O estado de DPE esteve associado às complicações pós-operatórias apenas nos pacientes submetidos a ostomias, sem presença destas associações nas esofagectomias.

Nutritional status of patients with gastrointestinal cancer receiving care in a public hospital, 2010-2011

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Thyroid hormone status interferes with estrogen target gene expression in breast cancer samples in menopausal women

We investigated thyroid hormone levels in menopausal BrC patients and verified the action of triiodothyronine on genes regulated by estrogen and by triiodothyronine itself in BrC tissues. We selected 15 postmenopausal BrC patients and a control group of 18 postmenopausal women without BrC. We measured serum TPO-AB, TSH, FT4, and estradiol, before and after surgery, and used immunohistochemistry to examine estrogen and progesterone receptors. BrC primary tissue cultures received the following treatments: ethanol, triiodothyronine, triiodothyronine plus 4-hydroxytamoxifen, 4-hydroxytamoxifen, estrogen, or estrogen plus 4-hydroxytamoxifen. Genes regulated by estrogen (TGFA, TGFB1, and PGR) and by triiodothyronine (TNFRSF9, BMP-6, and THRA) in vitro were evaluated. TSH levels in BrC patients did not differ from those of the control group (1.34 ± 0.60 versus 2.41 ± 1.10  μ U/mL), but FT4 levels of BrC patients were statistically higher than controls (1.78 ± 0.20 versus 0.95 ± 0.16 ng/dL). TGFA was upregulated and downregulated after estrogen and triiodothyronine treatment, respectively. Triiodothyronine increased PGR expression; however 4-hydroxytamoxifen did not block triiodothyronine action on PGR expression. 4-Hydroxytamoxifen, alone or associated with triiodothyronine, modulated gene expression of TNFRSF9, BMP-6, and THRA, similar to triiodothyronine treatment. Thus, our work highlights the importance of thyroid hormone status evaluation and its ability to interfere with estrogen target gene expression in BrC samples in menopausal women.