289 resultados para Teste de função cardíaca Avaliação
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OBJETIVO: Foi avaliar a frequncia e os fatores de risco de quedas em mulheres na ps-menopausa. MTODOS: Estudo clnico, transversal, envolvendo 358 mulheres (idade entre 45 e 65 anos e amenorreia >12 meses) com tempo de ps-menopausa <10 anos. Os critrios de excluso foram: doena neurolgica ou msculo esqueltico, vestibulopatias, hipertenso arterial no controlada, hipotenso postural, dficit visual sem correo, uso de medicamentos (sedativos e hipnticos). A queda foi definida como mudana de posio inesperada, no intencional, que faz com que o indivduo permanea em nvel inferior posio inicial. Foram analisados o histrico de quedas (ltimos 24 meses) e as caractersticas clnicas, antropomtricas (ndice de massa corprea (IMC) e circunferncia da cintura (CC)) e densidade mineral ssea. Na comparao segundo grupo de mulheres com e sem histrico de queda, foi empregado o Teste do Qui-quadrado ou Exato de Fisher e regresso logstica com clculo do odds ratio (OR). RESULTADOS: Entre as mulheres includas, 48,0% (172/358) referiram queda, com fratura em 17,4% (30/172). A queda ocorreu dentro de casa em 58,7% (101/172). A mdia de idade foi 55,76,5 anos, tempo de menopausa de 5,83,5anos, IMC 28,34,6 kg/m e CC 89,011,4 cm. Foi observada maior frequncia de tabagismo e diabetes entre as mulheres com histrico de quedas quando comparadas quelas sem queda, de 25,6 versus 16,1% e 12,8 versus 5,9%, respectivamente (p<0,05). Na anlise multivariada em função das variveis clnicas influentes, o risco de queda aumentou com o tabagismo atual (OR 1,93; IC95% 1,01-3,71). Demais variveis clnicas e antropomtricas no influenciaram no risco de queda. CONCLUSES: Em mulheres na ps-menopausa inicial houve expressiva frequncia de quedas. O tabagismo foi indicador clnico de risco para queda. Com o reconhecimento de fatores determinantes para queda, medidas preventivas so importantes, como a orientao de abolir o tabagismo.
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Ps-graduao em Estudos Lingusticos - IBILCE
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Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES)
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Ps-graduao em Agronomia (Agricultura) - FCA
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Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES)
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Ps-graduao em Sade Coletiva - FMB
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Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES)
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Ps-graduao em Ginecologia, Obstetrcia e Mastologia - FMB
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Fundao de Amparo Pesquisa do Estado de So Paulo (FAPESP)
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Fundao de Amparo Pesquisa do Estado de So Paulo (FAPESP)
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The comet assay is a method of DNA damage analysis widely used to quantify oxidative damage, crosslinks of DNA, apoptosis and genotoxicity of chemicals substances as chemical, pharmaceuticals, agrochemicals products, among others. This technique is suitable to detect DNA strand breaks, alkali-labile sites and incomplete excision repair sites and is based on the migration of DNA fragments by microeletroforesis, DNA migrates for the anode forming a tail, and the formed image has the appearance of a comet. The slides can be stained with fluorescence or silver, having differences in the microscopy type used for the analysis and the possibility of storage of the slides, moreover, the first one is a stained-method with more difficulties of accomplishment. The image analysis can be performed by a visual way, however, there is a disadvantage as the subjectivity on the results, that can be minimized by an automated method of digital analysis. This process was studied in this report with the aim to perceive the validation of the digital analysis turning it a quantitative method with larger reproductibility, minimizing the variability and imprecision due to the subjective analysis. For this validation we selected 50 comets photographed in a standardized way and printed, afterwards, pictures were submitted to three experienced appraisers, who quantified them manually. Later, the images were processed by free software ImageJ 1.38x, printed and quantified manually by the same appraisers. The intraclass correlation was higher to comet measures after image processing. Following, an algorithm of automated digital analysis from the measures of the comet was developed; the values obtained were compared with those 12 estimated manually after the processing resulting high correlation among the measures. The use of image analysis systems increases ...(Complete abstract click electronic access below)
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Contamination of rivers and lakes, waste disposed by infiltration into the soil as fertilizer, for example, has been highlighted around the world, since such compounds can contain toxic elements, causing changes in aquatic and/or terrestrial ecosystem. Due to the possible presence of these elements in these wastes, it is possible assess damage to organisms exposed through breaks in genetic material and mutations. In this sense, this work aimed at exploring the cytotoxic, mutagenic and genotoxic vinasse pontential, residue used as fertilizer, from the processing of sugar cane into alcohol, using fish (Oreochromis niloticus - Cichlidae) as a test organism. The individuals were exposed to different dilutions of vinasse in the water and later carried out analysis of their erythrocytes using the micronucleus test and nuclear abnormalities associated and the comet assay. In the first bioassay, tilapia exhibited 5% and 10% vinasse concentrations died after 48h. The number of micronucleated erythrocytes was statistically significant for the 1% vinasse concentration and also for nuclear abnormalities such as broken-egg and nuclear bud, when compared with negative and positive controls; were also significant lobed type erythrocytes, when compared to the negative control. The test results of the comet assay were not significant for 1% vinasse when compared to the negative control, due to the high rate of comets with damage control, which is unusual. The same was observed for changes as notched and blebbed type. In the second chemical analyzes conducted, the detection of heavy metals in the vinasse sample, charged only the presence of copper and chromium, the latter with a concentration 89 times higher than in the first test. Differentially the first bioassay, fish exposed to dilution of 5% did not die... (Complete abstract click electronic access below)
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O impacto das atividades antropognicas sobre o meio ambiente um tema de grande relevncia atualmente, atraindo a ateno da comunidade cientfica em geral, visto que essas atividades tm causado alteraes significativas na qualidade da gua, do solo e do ar. Dentre a ampla gama de poluentes resultantes das atividades humanas, merece destaque a classe dos metais pesados, os quais possuem propriedades txicas e genotxicas, constituindo fatores de risco para o desenvolvimento de desordens neurodegenerativas, artrite e cncer nas populaes expostas a estes contaminantes, bem como alteraes nos ecossistemas contaminados. Neste sentido, o presente trabalho teve por objetivo avaliar o potencial citotxico, genotxico e mutagnico do nquel como contaminante, utilizando Allium cepa (Liliaceae) como organismo-teste, a fim de detectar possveis efeitos deletrios em seu material gentico. Estas avaliaes foram feitas por meio da exposio de sementes de A. cepa a trs solues, com diferentes concentraes de nquel. Os resultados obtidos no primeiro biensaio e na repetio esto apresentados na forma de artigo cientfico, a ser submetido para revista especializada. O estudo dos efeitos do nquel em A. cepa foram importantes, uma vez que os dados da avaliação dos danos induzidos neste organismo modelo podem ser utilizados para a comparao com modelos animais, sendo possvel assim, a inferncia dos perigos aos ecossistemas e populao que est exposta a esse contaminante
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The aim of this study it was to evaluate the use of irrigating solution used during root canal preparation on the adhesive cementation of prefabricated fiberglass pins. The bond strength between different regions of the root and the fiberglass pins cemented into the root canal were evaluated by push-out assay. For this study, 36 human teeth were used, all equally prepared. The irrigating solutions used for biomechanical preparation were: saline solution, sodium hypochlorite 2,5% and glycolic extract of salvia 20%. The dual cure resin cement was used for cementation of pins. After cementation, specimens were sectioned to give 3 slices of approximately 2 mm each (cervical, middle and apical), which were submitted to mechanical push-out test. Were performed ANOVA and Tukey's test with a significance level of 5%, for the analysis of mechanical test. Comparing the thirds we observed that the only solution that presented statistical difference in the bond strength was sodium hypochlorite, which showed higher values for the middle and apical third compared with the cervical third, but when compared without taking into consideration the dental thirds, solutions studied showed no differences in bond strength. Therefore, it was concluded that the solutions studied can be used during endodontic treatment without causing harmful effects on the final adhesive restoration