Planejamento e síntese de novo candidato a fármaco útil para o tratamento de tumores sólidos

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Arvore dos sonhos: uma metodologia de planejamento participativo

O presente trabalho tem como objetivo desenvolver e avaliar a aplicação da oficina de futuro “Árvore dos sonhos” com os alunos de uma escola estadual, localizada em um bairro periférico na cidade de Botucatu, e identificar os temas geradores, as necessidades e as motivações sobre o aprendizado na escola, para o desenvolvimento de propostas de um projeto interdisciplinar relacionado à melhoria do ambiente escolar. Para Doll(1997) um currículo construtivo é aquele que emerge da ação e interação dos participantes. Hernandez (1998) afirmou que o papel do currículo integrado é educar para compreender e que interpretar é manifestar explicitamente a compreensão. Professores e coordenadores, geralmente, tem dificuldade em planejar e realizar trabalhos articulados, com isto poucos estudantes são capazes de vislumbrar a integração dos conteúdos vistos nas diferentes disciplinas, esta situação é constatada na realidade de muitas escolas brasileiras, que vêem buscando alternativas que contribuam para superar alguns dos obstáculos relacionados ao processo de ensino e de aprendizado. A atividade de construção da árvore dos sonhos foi proposta ao Ensino Médio para sensibilizar os alunos, para que pudessem se expressar, através de uma atividade interativa envolvendo a participação coletiva da turma. Cada sala foi responsável pela elaboração da idéia, construção, finalização, exposição dos sonhos e preservação da sua árvore dentro da sala de aula. Em algumas salas os temas geraram polêmicas e indignações diante da situação atual na escola, em outras não houve muito envolvimento dos alunos em virtude do sentimento de impotência, desmotivação e fracasso diante dos problemas dificultando a emergência de processos de mobilização que promovam em mudanças. Os sonhos e propostas escolhidos pelos alunos foram levados ao HTPC, para que em conjunto com o corpo docente, coordenadores da escola e a DE (Diretoria ...

Planejamento, síntese e avaliação da capacidade de doação de óxido nítrico de novos derivados antiinflamatóios

A formação do trombo arterial, composto predominantemente por plaquetas, se dá sob condições de estresse de cisalhamento elevado, nos locais de lesão aterosclerótica vascular e fluxo sanguíneo perturbado e tem como consequência diminuição ou obstrução do calibre dos vasos dos diferentes órgãos podendo levar a eventos isquêmicos. As doenças cardiovasculares são consideradas as principais causas de morte no mundo. Nesse contexto, estima-se que a aterosclerose/aterotrombose seja a causa primária de doença arterial coronariana e acidente vascular cerebral representado mais de 50% das causas de mortes em países ocidentais . É sabido que a aterosclerose, primeiro evento que predispõe à aterotrombose, é considerada um processo inflamatório crônico, e que a utilização de antiinflamatórios não esteroidais (AINEs) COX-1, melhor estabilizam a estrutura da placa ateromatosa impedindo o rompimento e a consequente formação do trombo. Neste contexto, no presente trabalho foram obtidos de novos candidatos a fármacos com propriedades doadoras de NO e antiagregantes plaquetárias, através da estratégia de hibridação molecular dos AINEs contendo uma subunidade doadora de óxido nítrico, representada pelos furoxanos, e espaçada por uma subunidade N-acil hidrazônica. Dessa forma, a inibição da síntese de tromboxanos associada à doação de óxido nítrico permitiu atuação nas plaquetas através de um mecanismo múltiplo de ação com fins de diminuição da agregação plaquetária. Os produtos intermediários e finais apresentaram bons rendimentos e foram caracterizados por técnicas analíticas as quais predisseram que as estruturas propostas foram obtidas. Todos os compostos se como doadores de óxido nítrico. Os compostos 1a e 3a apresentaram atividade analgésica superior a dipirona, utilizada como controle. No ensaio de agregação plaquetária ―in vitro‖... (Resumo completo, clicar acesso eletrônico abaixo)

Zoneamento acústico urbano e mapeamento de níveis sonoros na zona central de Rio Claro (SP): diretrizes para o gerenciamento do ruído integrado ao planejamento ambiental urbano

Considering the growing degradation of the urban environmental quality resulting from the progressive sound pollution increase, as well as the consequent harmful effects about the human health, the present study had its central objective the argument and management tools implementation of the urban noise that can be integrated to the environmental planning in the city of Rio Claro (SP). Therefore, normative and bibliographical revisions were developed, that made feasible the directives of control argument and prevention of the urban noise, as well as the technical procedures of sound levels and evaluation’s definition and especially about the criteria applicable for the elaboration of an urban acoustic zoning methodology. Among the main results obtained detach: (1) the applicable legislation to the management of urban noise’s synthesis and argument; (2) the methodology of urban acoustic zoning development and (3) its implementation to determined areas of Rio Claro (SP) with the (4) respective cartography representation; (5) the mapping of sound levels in the central zone of Rio Claro (SP), (6) the obtaining and analysis of noise describers (LAeq, Lmáx, L10, L50, L90, Lmin and TNI) and the subsequent (7) acoustic maps elaboration for the main describers.

Uso das técnicas de difusão em filmes finos por gradiente de concentração (DGT) para avaliação de metais disponibilizados em passivos de mineração de Urânio

The objective of this work is to use the technique of diffusion by concentration gradient films (DGT) for evaluation of dissolved urano in hydro bodies. For this we chose this work as a systems investigation of water bodies in the region of Poços de Caldas, state of Minas Gerais, because, there is a large amount of mining of uranila. The technique to be used to evaluate the potential for dissolved metals analysis involves the use of passive samplers with application in in situ. This allows detection with excellent sensitivity and selectivity allowing the determination of the labile fraction of dissolved metals

Análise de algoritmos computacionais utilizados em sistemas de planejamento de braquiterapia de alta taxa de dose: estudo comparativo com o Código MCNP-5C

In radiotherapy, computational systems are used for radiation dose determination in the treatment’s volume and radiometric parameters quality analysis of equipment and field irradiated. Due to the increasing technological advancement, several research has been performed in brachytherapy for different computational algorithms development which may be incorporated to treatment planning systems, providing greater accuracy and confidence in the dose calculation. Informatics and information technology fields undergo constant updating and refinement, allowing the use Monte Carlo Method to simulate brachytherapy source dose distribution. The methodology formalization employed to dosimetric analysis is based mainly in the American Association of Physicists in Medicine (AAPM) studies, by Task Group nº 43 (TG-43) and protocols aimed at dosimetry of these radiation sources types. This work aims to analyze the feasibility of using the MCNP-5C (Monte Carlo N-Particle) code to obtain radiometric parameters of brachytherapy sources and so to study the radiation dose variation in the treatment planning. Simulations were performed for the radiation dose variation in the source plan and determined the dosimetric parameters required by TG-43 formalism for the characterization of the two high dose rate iridium-192 sources. The calculated values were compared with the presents in the literature, which were obtained with different Monte Carlo simulations codes. The results showed excellent consistency with the compared codes, enhancing MCNP-5C code the capacity and viability in the sources dosimetry employed in HDR brachytherapy. The method employed may suggest a possible incorporation of this code in the treatment planning systems provided by manufactures together with the equipment, since besides reducing acquisition cost, it can also make the used computational routines more comprehensive, facilitating the brachytherapy ...

Aplicando Métodos de Mineração Visual de Texto em conteúdo de Fórum de Discussão

We are included in a society where the use of the Internet became very important to our everyday life. The relationships nowadays usually happen through technological devices instead of face to face contact, for instance, Internet forums where people can discuss online. However, the global analysis is a big challenge, due to the large amount of data. This work investigates the use of visual representations to support an exploratory analysis of contents in messages from discussions forums. This analysis considers the thematic and the chronology. The target forums refer to the educational area and the analysis happens manually, i.e. by direct reading message-by-message. The proprieties of perception and cognition of the human visual system allow a person the capacity to conduct high-level tasks in information extraction from a graphical or visual representation of data. Therefore, this work was based on Visual Analytics, an area that aims create techniques that amplify these human abilities. For that reason we used software that creates a visualization of data from a forum. This software allows a forum content analysis. But, during the work, we identified the necessity to create a new tool to clean the data, because the data had a lot of unnecessary information. After cleaning the data we created a new visualization and held an analysis seeking a new knowledge. In the end we compared the new visualization with the manual analysis that had been made. Analyzing the results, it was evident the potential of visualization use, it provides a better correlation between the information, enabling the acquisition of new knowledge that was not identified in the initial analysis, providing a better use of the forum content

Diagnóstico ambiental do município de Ipeúna: subsídios para o planejamento do turismo

This study sought to address the tourism system in its various strands, compared to socioeconomic and environmental issues. Contextualizing the theme of sustainable tourism, or ecotourism, the reality of the city of Ipeúna, there is the incipient state of efforts in this activity because, predominantly, its territory is occupied by the monoculture of cane sugar and pastures, which damages the maintenance of vegetation fragments, as well as degrading areas that often could take a value tour. Through environmental planning, was intended to raise major issues of interface tourism / environment in order to seek alternatives to the implementation and development of tourism in Ipeúna. As a result, it presents an environmental diagnosis of the study area through which to assess the current status of tourist attractions in relation to environmental and socio-economic dynamics of the city.

Relações públicas e o planejamento estratégico nas instituições de ensino superior privadas

The society of the information brings with it a lot of changes day by day of the organizations, mainly for characterizing as a flexible society, in net and ruled in technological progress. The contemporary organizations are inserted in that reality and they need be maintained in markets more and more competitive. The Private Institutions of Higher education enter in this logic for they be organizations with lucrative ends that suffer strong influence of the external and internal atmosphere. To stand out, such Institutions need to count with a strategic administration, ruled in an own strategic planning for the branch in that acts. The professional of public relationships is shown capable to develop their main functions in such complex market. For so much it needs to participate in the global planning of the Private Institutions of Higher education, at the same time in that it develops it planning of the communication, intrinsic to the global strategic planning. This way, the present study treats of the professional's of Public Relationships possible contributions, ruled in theoretical data, inside of Private Institutions of Higher education in the Brazilian current scenery

Utilização de técnicas de geoprocessamento para monitoramento de atividades de mineração ao longo de dutos: poliduto Rio de Janeiro/Minas Gerais

The transportation of oil through polyducts implies a concern related to safety and environmental impacts they may cause, especially when exposed to risks that affect their integrity. Among the various anthropogenic activities included in this scenario, mining can aggravate, increase the risks and degrade the environment. Since these polyducts go through significant extensions, remote sensing has great applicability as a tool for data acquisition. For this, change detection techniques were used to monitor mining activities in a defined study area in the state of Rio de Janeiro, along the duct ORBEL. The characterization of the study area and the mining activities were developed through bibliographical data. The satellite images processing and the application of change detection technique were performed in two scenes for the years 2002 and 2010. The growth in the mining area was about 6.67 times and it was possible to identify types of extraction involved which can represent direct risks to the pipeline

Planejamento ambiental do distrito de Ameliópolis – Presidente Prudente - SP

The concern with the environmental planning has become important in Brazil recently. Until then, nature was conceived as a resource, because of the implementation of developmental policies that perdured to the 1970s, based on the expansion of the industrial complex, altogether hadn´t preoccupation by the federal government with the relationship between society and nature. During this period, after the threat of not receiving more international investment to finance large projects in the country, accompanied by pressure from civil society organizations, the federal government began to take some action related to the environment, such as the creation of federal agencies (IBAMA), application of environmental laws and decrees in order to create rules for the proper use of natural resources such as water, soil and air. From the decade of 1990 onwards the master plans have become a mandatory document for all municipalities in the country with a population over 20,000 inhabitants, ranging from health issues to the development of urban, rural and environmental planning. Thus, the environmental planning gained prominence in the political scene. Therefore, to achieve environmental planning is necessary to follow some social and environmental parameters, which for this survey, conducted in the District of Ameliópolis – Presidente Prudente... (Complete abstract click electronic access below)

Planejamento ambiental da bacia hidrográfica do córrego Embirí – UGRHI Pontal do Paranapanema – São Paulo: inventário e diagnóstico

This study aimed to contribute to the environmental planning of the watershed Embirí stream - UGRHI Pontal Paranapanema (belonging to the Paranapanema Management unit) in the cities of Presidente Prudente and Regente Feijó, São Paulo. This basin is located in the area of the Santo Anastácio river source, responsible for supplying water to about 30% of the population of Presidente Prudente. The methodological procedures based on Leal (1995) and Rodriguez et al. (2004), and the steps include inventory and diagnosis of the basin. We conducted extensive literature review, cartographic and documentary on the subject area of research, field work, preparation of thematic maps and summary chart of physical units and environmental use and land cover, participatory mapping of environmental risks, quality analysis of water. Most of the basin of the stream of twine had a high environmental fragility and the main problems found were lack of riparian vegetation, erosion, siltation of water bodies, irregular disposal of debris and the dumping of sewage. The results were summarized in the diagnosis and can identify the most important environmental impacts, environmental and spatial weaknesses of the legislation, and thus draw up proposals for action to the area that is substantially degraded

Carvão (Sporisorium scitamineum) e podridão-abacaxi (Ceratocystis paradoxa) em cana-de-açúcar (Saccharum spp.): uma revisão

Sugarcane (Saccharum sp.) is an important grass cultivated in tropical and subtropical regions of the world, such as in Br, Ind, and Ch, and has its biomass being raw material for production of sugar, fuel ethanol, and some other derivatives. Fungal diseases infect sugarcane fields worldwide, damaging crops and thus, causing great economic losses. Fungal specialized structures act during all Pathogen-Host Relationship Cycle (PHRC) (survival, dissemination, infection, colonization, and reproduction of pathogen), maintaining fungal populations in cultivation soil, infecting plants in following crops and vegetative propagation of sugarcane by infected seeds may allow fungal transportation into regions where diseases haven’t occured before. Biotechnological methods and approaches have significantly contributed to understanding of the relationship among parasite and host, as to diseases management (control, detection, and prevention). Some techniques have daily applications in Agriculture, while others are only used in research and to breeding of host resistant varieties. Among notable diseases, smut (Sporisorium scitamineum) and pineapple disease (Ceratocystis paradoxa) are important because they cause damage and losses in sugarcane regions, although there are different periods for each one to occur. This work aims to review the PHRC for each patosystem, the biotechnological methods and approaches and its perspectives in the study and management of these diseases. As environment is an important factor to the effectiveness of PHRC, one chapter is dedicated to Global Climate Change (GCC) and its possible influences over these diseases in a longterm period

Diagnóstico ambiental de atividades de mineração com ênfase em olarias no município de Rio Claro (SP)

The environmental diagnosis of any area affected for mining activities contributes in a positive form for the analysis of the characteristics of the environment, biological and social, thus being able to establish control parameters. The clay extration for red ceramics promotes the environment degradation as any another one cultivates of mineral goods, but in lesser scale, which had to the dimensions of potteries. Being thus, some decurrent environment characteristics of the clay extration had been inquired clearly used for potteries located in the city of Rio Claro, SP. For this, the followed method was the cadastre of these areas and potteries in created tables, searching, with this, the contribution for the involved people in the extract activity of related potteries and the facilitation in the visualization of the main problems, necessities and proposals for each one. It could be perceived that the environmental diagnosis of the areas had in common presented referring points to the places where if they find the activities. The same ones are located in the region the northwest of Rio Claro and well next one to the others. Moreover, they have in common, referring characteristics to the process of manufacture of bricks. In common, all the responsibility for the administration and course of the activities competes to the proper families, since the administrative part, even though to the process of manufacture of the bricks. Moreover, from the comment of the areas through field work, the prominent use of diverse areas in the region for the clay extration is noticed, making with that the region has great importance in the regional scene.

Planejamento ambiental da Bacia Hidrográfica do Córrego da Olga, UGRHI Pontal do Paranapanema – São Paulo: inventário e diagnóstico

This work, presented in order to obtain the environmental engeneer title, is to raise the current status of environmental conditions in the watershed of the stream of Olga and thus contribute to environmental planning for the recovery, conservation and preservation. To this end, we conducted literature surveys and survey of the characteristics of the watershed, analysis of water fron stream of Olga and making use of remote sensingand of the soil, environmental fragiityand spatialization of APPs in order to carry out further research on the environmental conditions of the basin, as well as inferences about possible causes of degradation of watershed.Most of the basin of the stream Olga had a high environmental fargility and the main problem was the lack of riparian vegetation is also considered the cause of environmental problems of the watershed.The results will be available to municipal governments in order to contribute to their planning and management of UGRHI the teh watershed pertence