European Ancestry Predominates in Neuromyelitis Optica and Multiple Sclerosis Patients from Brazil

Background: Neuromyelitis optica (NMO) is considered relatively more common in non-Whites, whereas multiple sclerosis (MS) presents a high prevalence rate, particularly in Whites from Western countries populations. However, no study has used ancestry informative markers (AIMs) to estimate the genetic ancestry contribution to NMO patients. Methods: Twelve AIMs were selected based on the large allele frequency differences among European, African, and Amerindian populations, in order to investigate the genetic contribution of each ancestral group in 236 patients with MS and NMO, diagnosed using the McDonald and Wingerchuck criteria, respectively. All 128 MS patients were recruited at the Faculty of Medicine of Ribeirão Preto (MS-RP), Southeastern Brazil, as well as 108 healthy bone marrow donors considered as healthy controls. A total of 108 NMO patients were recruited from five Neurology centers from different Brazilian regions, including Ribeirão Preto (NMO-RP). Principal Findings: European ancestry contribution was higher in MS-RP than in NMO-RP (78.5% vs. 68.7%) patients. In contrast, African ancestry estimates were higher in NMO-RP than in MS-RP (20.5% vs. 12.5%) patients. Moreover, principal component analyses showed that groups of NMO patients from different Brazilian regions were clustered close to the European ancestral population. Conclusions: Our findings demonstrate that European genetic contribution predominates in NMO and MS patients from Brazil. © 2013 Brum et al.

The Number of Bleaching Sessions Influences Pulp Tissue Damage in Rat Teeth

Introduction: Hydrogen peroxide tooth bleaching is claimed to cause alterations in dental tissue structures. This study investigated the influence of the number of bleaching sessions on pulp tissue in rats. Methods: Male Wistar rats were studied in 5 groups (groups 1S-5S) of 10 each, which differed by the number (1-5) of bleaching sessions. In each session, the animals were anesthetized, and 35% hydrogen peroxide gel was applied to 3 upper right molars. Two days after the experimental period, the animals were killed, and their jaws were processed for light microscope evaluation. Pulp tissue reactions were scored as follows: 1, no or few inflammatory cells and no reaction; 2, <25 cells and a mild reaction; 3, between 25 and 125 cells and a moderate reaction; and 4, 125 or more cells and a severe reaction. Results from each experimental group were compared between groups and within groups to the corresponding unbleached upper left molars and analyzed for significant differences using the Kruskal-Wallis test (P < .05). Results: All tissue sections showed significant bleaching-induced changes in the dental pulp. After 1 bleaching session, necrotic tissue in the pulp horns and underlying inflammatory changes were observed. The extent and intensity of these changes increased with the number of bleaching sessions. After 5 sessions, the changes included necrotic areas in the pulp tissue involving the second third of the radicular pulp and intense inflammation in the apical third. Conclusions: The number of bleaching sessions directly influenced the extent of pulp damage. © 2013 American Association of Endodontists.

Variação genética, herdabilidades e ganhos na seleção para caracteres de crescimento e forma, em teste de progênies de polinização aberta de Eucalyptus cloeziana, aos 24 anos de idade em Luiz Antônio-SP

Pós-graduação em Agronomia - FEIS

Caracterização da vegetação secundária do bioma mata atlântica com base em sua posição na paisagem

This study characterized the Atlantic Forest vegetation and compared the structure of the native tree community occurring along a toposequence at watershed D of the Serra do Mar State Park, municipality of Cunha, SP - Brazil. The study was conducted in 64 plots, of 10 x 10 m, distributed in sites downstream (T1), intermediate (T2) and upstream (T3) of the toposequence, recording all individuals with DBH (Diameter at Breast Height) >= 0.5 cm. Altogether 1.093 individuals were sampled, and 89 species were identified, belonging to 61 genders and 31 families. At T1 site there was a greater abundance and density of individuals; T2 had the highest diversity index and basal area; while in T3 it was observed highest species richness and greater percentage of rare species. The specie Cyathea delgadii in the lower third of toposequence, and the Alchornea triplinervea in the intermediate and upper third were the most important. The sites downstream and upstream of the toposequence showed the largest differences in structure. In the middle portion of the watershed and there was a greater difference between the similarity between species.

Analysis of cardiac autonomic modulation of children with attention deficit hyperactivity disorder

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Decreased rate of protein synthesis, caspase-3 activity, and ubiquitin-proteasome proteolysis in soleus muscles from growing rats fed a low-protein, high-carbohydrate diet

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Nutrição e produtividade da nogueira-macadâmia em razão do parcelamento da adubação mineral

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Photoelastic stress analysis of splinted and unitary implant-supported prostheses

The aim of this study was to evaluate the effects that splinting and different lengths of implants have on the stress distribution in implant-supported prostheses by photoelastic analysis. A total of five photoelastic resin models were made with different proposed situations, and 400 load applications were performed for the analysis. Compared with the unitary prosthesis, the splinted implant-supported prosthesis acted favorably in the distribution of stresses and strains to the implant (p < 0.001). The increase in length was a significant factor in the stress distribution (p < 0.05) and, ultimately, the overall reduction in stress. It was concluded that the splinted implant-supported prosthesis behaved better biomechanically compared with the unitary prosthesis.

O grupo escolar de São Luiz do Paraitinga: contexto histórico (décadas de 1930 a 1970)

The present work has as its theme the group of St. Louis School of Paraitinga: historical context (the 1930 to 1970). This work has the distinction the subject rarely addressed in academic, school groups in the region of Vale do Paraiba, these schools are not constant theme of research, making this differentiation materials present little used, but extremely important for understanding of education present in the region of Vale do Paraíba. For the realization was made to read the legislation in the period 1930 to 1970, the documentation provided by the Department of Education, reading and analysis of documentation presented, one can understand the historical context of the school group to be targeted by the study: School Group Colonel Domingues de Castro. Objective of this study was to understand how the group of the school of St. Louis was shaping up Paraitinga laws and guidelines in the historical context of the decades from 1930 to 1970, contextualizing historical events general and the specific events of São Luiz do Paraitinga. The methodology used is studies of educational phenomena along with the narrative-biographical study of respondents to this survey

Median preoptic nucleus mediates the cardiovascular recovery induced by hypertonic saline in hemorrhagic shock

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Melatonin attenuates Her-2, p38 MAPK, p-AKT, and mTOR levels in ovarian carcinoma of ethanol-preferring rats

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Zaira de Bittencourt Martins: pioneira da psicanálise de crianças no Rio Grande do Sul

The objective of the present article is to introduce Zaira de Bittencourt Martins’s contributions to psychoanalysis in Rio Grande do Sul, identifying her as pioneer in child psychoanalysis in this State. Starting from a historic research based on interviews with psychoanalysts, bibliographical sources and contacts with relatives, the author composed a biographical outline of the psychoanalyst above mentioned. Zaira Martins, together with her husband, the psychiatrist and psychoanalyst Mario Martins, immigrated to Argentina in 1944, and in 1947 was recognized as an analyst by the Argentinian Psychoanalytic Association. On her return to Brazil she became the first non physician woman to make part of the Psychoanalytic Society of Porto Alegre, collaborating with her foundation, in 1963. She played the pioneer role as child psychoanalyst and contributed in the dissemination of Kleinian ideas in her State. She also contributed in the formation of young analysts who were beginners in the child analyst field, through courses and supervisions.

Melatonin attenuates the TLR4-mediated inflammatory response through MyD88-and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Measurement of the pp → ZZ production cross section and constraints on anomalous triple gauge couplings in four-lepton final states at √s = 8 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)