Desafios tecnológicos na exploração de petróleo em águas profundas: o sistema PETROBRAS de inovação

Pós-graduação em Economia - FCLAR

Explicação e argumentação na linguagem da criança: diferenças e intersecções em dois estudos de caso

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Avaliação comparativa do processo de incorporação de bloco sintético bifásico, e do osso autógeno: estudo histológico, histométrico e imunoistoquímico em coelhos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Influência da inalação da fumaça de cigarro no reparo de enxertos ósseos autógenos onlay em ratas ovarectomizadas: estudo histomorfométrico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Regeneração óssea guiada com o uso de membrana de copolímero PLA/PGA em levantamento da membrana do seio maxilar: estudo experimental com análises histomorfométrica e imunoistoquímica

Pós-graduação em Odontologia - FOA

Implantes dentais curtos: alternativa conservadora na reabilitação bucal

The short dental implants represent an option of previsible treatment, its main indication lives in the possibility of avoiding techniques surgical invasive. The literature in the display that the geometry of the implants is of vital importance, combined with wide diameters and surface treatment, mainly when the bone quality is unfavorable. The mechanical resistance can be enlarged, increasing the number of implants and being used the spliting among them. A rigorous protocol prosthodontist should be following with intention of to avoid oblique loads and to control habits parafuncionais. We aimed at to discuss, through a wide bibliographical revision the short dental implants, their characteristics and indications, giving emphasis to the aspects biomechanic of the same ones. Material and Method: The bases given: Pubmed, ISI and Dentistry Oral Science from 1990 to 2009, were consulted to identify researches related to the length of the dental implants, with emphasis to the considered short and the biomechanics related to the same ones. They were located 568 articles, being selected 69 that gathered the inclusion criteria. Result: Among these 69 selected, 26 articles agreed the evidence level. Conclusion: Inside of the limits of appraised data, it can be concluded that the short implants represent a good treatment alternative, especially for cases with reduced bone bed. However a rigorous indication protocol and use should be followed for warranty of the success of the treatment.

Notificações espontâneas de eventos adversos a medicamentos hospitalares: estudo piloto

Introduction: Post-marketing surveillance of drugs aims to detect problems related to safety, effectiveness and quality. The identification of adverse drug events (ADE) is made, mainly, by health professionals´ spontaneous reporting. This method allows risk communication in pharmacovigilance and contributes for market regulation. Objective: To estimate the prevalence of adverse drug reaction (ADR) and the suspicions of therapeutic failure (TF) reported by health professionals; to verify the active principle and type of drugs related to ADE, seriousness, causality, production mechanism and clinical manifestation of the events identified. METHODS: A cross-sectional study was performed in a teaching and public hospital which integrates the Sentinel Hospital Network, in 2008. ADR seriousness was classified according to intensity (mild, moderate, serious and lethal); drugs associated with ADE were categorized according to type (brand name drugs and non-brand name drugs); causality was imputed with Naranjo algorithm and the mechanism of occurrence was analyzed according to Rawlins e Thompson definitions (A or B). Results: There were 103 ADE reports in the period, of which 39 comprised TF and 64 ADR. Nurses reported the most ADE (53.4%). The majority of ADR were classified as type A (82.8%), mild (81.3%), possible (57.8%), according to causality assessment, and related to brand name drugs (20/35). Human immunoglobulin, docetaxel and paclitaxel were the drugs frequently associated with ADR. TF arising from no-brand name drugs (26/29), regarding, mainly, midazolam and ganciclovir. Conclusion: The results of the ADE report contribute for proposition of trigger tools for intensive monitoring of drug safety, as well as for the supplier qualification and for the improvement of quality products.

Reconstrução de maxila severamente atrófica via enxerto ósseo autógeno de calota craniana: descrição de técnica

Bone reconstructions are traditionally conducted with autogenous grafts harvested from intra- or extra-oral donor sites to reestablish the lost bone volume for further implant-prosthetic rehabilitation. The calvarial bone has been studied as an excellent donor site in large atrophic situations, presenting low resorption rates, as well as complications and minimal morbidity. The hospitalization time is short, with low pain levels, short functional limitations, and invisible scars. The skull microarchitecture is predominantly cortical in the presence of growth factors that demonstrate their osteogenic, osteoinductive, and osteoconductive abilities resulting in low resorption rate and high predictability when compared to the iliac crest. Dural lacerations, extra and subdural bleeding, cerebrospinal fluid leakage, and brain damage have been minimized due to the development of surgical technique. The delimitation of diploe, preserving the internal skull cortex before osteotomy at the donor made it possible to reduce accidents and complications. The aim of this paper is to show a technical and to discuss aspects of the use of calvarial bone in the reconstruction of severely atrophic maxilla for oral rehabilitation with osseointegrated implants.

Avaliação da incorporação de enxerto osseo homogeno fresco congelado em humanos: análise histologica e imuno-histoquímica

Allogeneic, fresh-frozen bone has been used in order to replace bone autografts. However, its osteoinduction and osteoconduction properties are not well-defined in the scientific literature. This work aimed to evaluate samples of homogenous bone grafts in humans by qualitative histological and immunohistochemical analysis. For this, ten pre-selected patients underwent surgical augmentation of bone defects. The homogenous fresh frozen block bone graft was stabilized and fixed by bicortical screws. After six months, the reopening procedure was performed for installation of osseointegrated implants. At this time surgical bone graft samples were removed by means of drill trephine. The samples were fixed in 10% formalin, processed with decalcified paraffin, and stained with hematoxylin and eosin. Immunohistochemistry was performed for the expression of Caspase 3 enzyme. The slides were brought to light microscopy for qualitative histology and immunohistochemistry. The results showed non-vital bone tissue, with few areas of deposition of new bone formation on the amorphous matrix, presence of chronic inflammatory infiltrate with areas of osteomyelitis, and expressive immunolabeling of Caspase 3. Given the methods employed and the results it was concluded that the allograft fresh-frozen block is not incorporated into the recipient bed after a healing period of six months.

Processo de obtenção de ácido acrílico a partir do glicerol e uso de vanadosilicatos microporosos no referido processo

A tecnologia descrita na presente invenção se refere ao processo de obtenção de ácido acrílico a partir do glicerol, utilizando vanadosilicatos microporosos como catalisadores de maior seletividade, estabilidade frente à deposição de coque e alta conversão de glicerol em ácido acrílico. Ainda, menciona-se a utilização de catalisadores bifuncionais no referido processo, sendo estes capazes de desidratar o glicerol e oxidar a acroleína formada até ácido acrílico em um único leito catalítico.

Tratamento de águas residuárias de suinocultura em reatores anaeróbios horizontais de alta taxa seguidos de filtro biológico percolador

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Caracterização de úlceras venosas através da expressão de proteínas presentes no exsudato inflamatório

Pós-graduação em Doenças Tropicais - FMB

Melanoma subungueal in situ tratado com cirurgia funcional

Melanoma subungueal in situ tratado com cirurgia funcionalHamilton Ometto StolfI, Hélio Amante MiotI, Nilton de Ávila ReisIIDepartamento de Dermatologia e Radioterapia, Universidade Estadual Paulista (Unesp)INTRODUÇÃOO melanoma subungueal representa aproximadamente 2% a 3% dos melanomas cutâneos em pacientes caucasianos1 e 20% em pacientes negros2 ou asiáticos.3A exposição solar, tida com principal fator de risco para o melanoma cutâneo,4 parece desempenhar papel secundário no desenvolvimento da variante subungueal,5 uma vez que a radiação ultravioleta dificilmente penetra no leito ungueal. Além disso, nevos subungueais como lesões precursoras são extremamente raros.6Os polegares e háluces são os mais acometidos, sendo o polegar responsável por 56% dos casos entre todos os dedos e o hálux por 86% dos dedos dos pés.7A confirmação do diagnóstico é feita a partir do exame anatomopatológico da lesão, geralmente localizada na matriz ou leito ungueal. A verificação histológica do melanoma subungueal é frequentemente postergada por conta do atraso no diagnóstico clínico,8-10 gerando piora do prognóstico.O prognóstico geralmente é ruim: as taxas de sobrevida real de cinco anos variam entre 16% a 20%, podendo atingir até 80% se consideradas taxas de sobrevida estimada.2,3,11-18RELATO DE CASOPaciente de 44 anos, do sexo feminino, professora, com queixa de aparecimento de mancha na unha do hálux direito há cinco anos. Relata aumento progressivo lento na largura da faixa. Ao exame dermatológico, apresentava faixa de melanoníquia extensa, irregular, bordas mal definidas e estria de pigmentação mais acentuada em uma das margens do leito ungueal do hálux direito (Figura 1). Exame dermatoscópico (aparelho Dermalite II Pro, aumento de 10 vezes) confirmou faixas irregulares e cores variadas de hiperpigmentação.Foi realizada a avulsão parcial da lâmina ungueal e incisão na prega ungueal lateral para visualização do local da origem da pigmentação no leito ungueal,

Hiperadrenocorticismo em cães: revisão

Hyperadrenocorticism is a relatively common endocrinopathy in dogs, which is associated to an excessive production or administration of cortisol. The most affected breeds are Poodles, Teckels, Boxers, Boston Terriers and Beagles. The clinical signs most commonly observed are polyuria, polydipsia, polyfagia, panting, distended abdomen, endocrine alopecia, muscular weakness and lethargy. Laboratorial abnormalities include stress leukogram, increase in alkaline phosphatase and alanine aminotransferase activities, hypercholesterolemia, lipemia, hyperglycemia and hyposthenuria. The preferred essay to evaluate adrenal gland function is the low-dose dexamethasone suppression test, whereas the most used treatments include mitotane and trilostane. The objective of this paper is to review hyperadrenocorticism in dogs, because this disease is relatively common in small animal clinics and has many long-term complications.

Composição florística e estrutura vegetacional da mata ciliar de um remanescente florestal em Paraguaçu Paulista, SP

Pós-graduação em Biociências - FCLAS