244 resultados para Biópsia por agulha
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Pós-graduação em Ciência Odontólogica - FOA
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Pós-graduação em Patologia - FMB
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Pós-graduação em Desenvolvimento Humano e Tecnologias - IBRC
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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The real role of renal transplantation in hepatic fi brosis progression caused by hepatitis C virus is still unpredictable. Histological evaluation of the liver is the best form to estimate fi brosis evolution, although semiquantitative analysis carries important limitations. Objective: To apply a morphometric quantitative assay on hepatic fi brosis progression in renal recipients with hepatits C. Methods: Thirty patients were initially evaluated, but only seven were included. They underwent the fi rst biopsy near the transplantation date and the second biopsy at least 4 years later. The immunosuppressant therapy adopted in all cases was azatioprine and micofenolate. Fibrosis progression rate (FPR) was calculated before and after the surgery date in each patient according to Metavir score and morphometric analysis. Results: The FPR calculated by Metavir score showed no statistical difference between pre- and post-transplantation (p=0.9). The FPR calculated by the morphometric analysis was 0.58 ± 0.78 before transplantation and 3.0 ± 3.3 after the surgery, with statistical signi- fi cance between these values (p=0.0026). Conclusion: In the sample assessed, the progression of hepatic fi brosis was documented and quantifi ed only by the morphometric analysis, which is as a promising approach to histological evaluation of these patients.
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There are only 10 reported cases of pancreatic hemangiomas in adults, only one of them causing digestive bleeding. We present a case of variceal bleeding and portal hypertension caused by a pancreatic hemangioma. The patient had 19 year-old and was received at her 16th week of pregnancy. She had massive hematemesis, controlled after variceal band ligation. Her image exams revealed a cystic lesion of 164 cm³ in the pancreas tail and signs of portal hypertension. Two months after, the ultrassonographic exam documented the lesion growth, achieving 200 cm³ at that time. The patient was submitted to distal pancreatectomy, and the histopathological analysis revealed a pancreatic hemangioma of 11 x 9 x 8 cm. Therefore, we report the second case of digestive bleeding caused by a pancreatic hemangioma, which had a well documented growth during the pregnancy. Additionally, we review the previous reports of pancreatic hemangiomas and discuss the hypothesis of hormonal infl uence on the natural history of these tumors.
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Paciente feminino 36 anos, com queixa de febre noturna, astenia, parestesia de membros inferiores, artralgia, hepatoesplenomegalia, lesões cutâneas, anemia hipocrômica, microcítica e linfopenia. Sorologia negativa para Hepatite B,C e HIV; FAN e anti-DNA também negativos. Histopatologia da medula óssea mostrou-se discretamente hipercelular, com presença de focos de histiócitos com citoplasma vacuolado (células pseudo-gaucher-like),aspecto megaloblástico, linfoplasmocitico e lipogranulomatoso. A coloração Ziehl- -Nielsen positivo; diagnóstico morfológico: micobacteriose de medula óssea. A cultura do sangue e do aspirado de medula óssea foi negativo para M.tuberculosis. Biópsia das lesões cutâneas máculas e pápulas hipercrômicas dos membros inferiores e superiores revelou hanseníase de padrão Vichowiana. A pesquisa BAAR pela Faraco demonstrou numerosos bacilos, sendo a maioria de padrão granuloso. Pacientes com hanseníase virchowiana tem acometimento cutâneo em 100% dos casos, o baço é o órgão mais frequentemente acometido com disseminação através do sangue periférico. O quadro anêmico e a linfopenia provavelmente se deve à cronicidade da infecção, levando a infiltração medular. A ocorrência do comprometimento medular em paciente com hanseníase Virchowiana é excepcional, mesmo em países endêmicos, e pode indicar necessidade de tratamento mais prolongado.
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This study, clinical, prospective, randomized study was conducted from August 2004 to February 2008 in a convenience sample of 60 women who underwent breast surgery with axillary dissection, divided into two groups (n = 30). The GI (Guidance Kit with different textures, to perform at home) and GII (control). The objective was to analyze the effect of home orientation in patients after surgery for breast cancer complaining of numbness, evaluation, and the conventional esthesiometer. The surface sensitivity was assessed by monofilament Semmes-Weinstein and evaluation using conventional two test tubes with hot water (38 to 43o C) and cold (16 to 27o C), paintbrush, needle. The GI was subjected to 10 sessions and assessments in both 3 times. The M1 (pre intervention), the M2 (post-intervention) after 10 sessions of physical therapy intervention and M3 (washout) after 3 months the second time for assessment. The region targeted for evaluation and intervention was the sensory nerve dermatome intercostobrachial. In the test of Goodman (conventional assessment) there was improvement in both groups, the P1, during the thermal evaluation. The t-test of student (esthesiometer) there was improvement in P2 only in GI (p = 0.003) between points 1 and 2 while the time 3 (p = 0.121 and p = 0.733 respectively). It was concluded that there were divergent and opposite results after examining the effect of home orientation in the nerve dermatome intercostobrachial, evaluation, and the conventional esthesiometer.
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Lissencephaly is a condition characterized by a lack of cerebral convolutions and sulci, which results from defective migration of nervous cells precursors in the telencephalus. The cause is presumably genetic. Lhasa-Apso dogs are most frequently affected, even though it may also occur in association with cerebellar hypoplasia in the Irish Setter, Wire-Haired Terrier and Samoieda breeds. This association was also reported in a cat. Clinical signs consist of dementia, aggressiveness, seizures, visual and olfactive dysfunctions, slow postural reactions and reduced menace response. Definitive diagnosis requires exams such as magnetic resonance imaging, cerebral biopsy or necropsy. There is no specific therapy for this disease, and seizures must be treated with anticonvulsants. The aim of this study is to review the literature regarding lissencephaly.
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Fundação de Apoio à Pesquisa do Estado de São Paulo (FAPESP)
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Contexto e objetivo: A hanseníase caracteriza-se por ter diagnóstico eminentemente clínico, principalmente através da constatação de hipo ou anestesia das lesões, ou seja, sem necessariamente o uso de exames adicionais, como baciloscopia e biópsia, utilizados para classificação clínica da doença. Buscou-se definir se há tendência à desvalorização da avaliação clínica em favor do excesso de exames complementares, investigar a adequação do registro nos atendimentos da atenção básica e compará-los com o obtido em serviço de média complexidade. Desenho e local: Estudo transversal, de base populacional, utilizando registros de prontuários, realizado em dois âmbitos de atendimentos de saúde da cidade de Campinas (SP): os Centros de Saúde e a assistência dermatológica especializada de hospital de ensino. Métodos: Os registros foram investigados por meio da aplicação de checklist, contendo itens indispensáveis ao atendimento a hansenianos. Associações foram testadas pela prova de Goodman e ao nível de 5% de significância. Resultados: Foram avaliados 33 prontuários oriundos dos centros de saúde e 36 do hospital, observou-se polarização entre registros adequados e ausentes, evidenciando a presença de efeito tudo ou nada nos atendimentos; de 26 variáveis, apenas em 5 (19,23%) obteve-se predomínio da avaliação do hospital sobre os centros de saúde; evidenciou-se dependência de exames complementares, solicitados em 67 dos 69 atendimentos (97,10%), para diagnóstico da doença. Conclusão: Confirmou-se, neste estudo, déficit da avaliação médica e indicação inadequada de exames adicionais. Por associar-se com excesso de solicitação de exames, a observação clínica mostrou-se incompleta, comprometendo a capacidade diagnóstica dos atendimentos a hansenianos.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Pós-graduação em Engenharia Civil e Ambiental - FEB
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)