245 resultados para seleção do doador
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Pós-graduação em Ciências Biológicas (Microbiologia Aplicada) - IBRC
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Pós-graduação em Design - FAAC
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Pós-graduação em Agronomia (Genética e Melhoramento de Plantas) - FCAV
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Pós-graduação em Desenvolvimento Humano e Tecnologias - IBRC
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Pós-graduação em Agronomia (Proteção de Plantas) - FCA
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As celulases atualmente são enzimas extensivamente estudadas para a hidrólise de resíduos lignocelulósicos para obtenção de açúcares fermentescíveis utilizáveis em diferentes processos biotecnológicos, como a produção de bioetanol. O objetivo deste trabalho foi encontrar fungos celulolíticos que sejam eficientes nos processos de degradação da biomassa lignocelulósica. No presente trabalho foram selecionados 4 fungos celulolíticos previamente isolados pelo Laboratório de Biotecnologia Industrial (UNESP – Assis). Estes fungos foram cultivados em bagaço de cana-de-açúcar como substrato e para seus extratos enzimáticos foram testados suas atividades para celulases (FPase) e endoglucanases (CMCase). Os fungos FS09 (0,054 FPU/mL e 1,79 FPU/g de substrato, 0,874 U/mL e 29,1 U/g de substrato) e M51 (0,049 FPU/mL e 1,62 FPU/g de substrato, 1,094 U/mL e 36,46 U/g de substrato), mostrando valores superiores ao fungo T.reesei CCT 2768 que é referência em estudos e produção de celulases.
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Abstract Introduction: Indications for induction therapy is not consensual in living donors. Objective: The objective of this study was compare no induction with thymoglobulin and basiliximab induction in the incidence of acute rejection in kidney transplantation with living donor. Methods: We select all cases of renal transplantation with living donor performed in Hospital das Clínicas de Botucatu da UNESP during the period of January 2010 to December 2013. The group was divided by the type of medication used for induction. Results: A total of 90 patients were evaluated. There were no differences in baseline characteristics of age and underlying disease. The rate of biopsy-proven acute rejection was higher in the group without induction (42.9%) compared to basiliximab group (20%) and Thymoglobulin (16.7%), p = 0.04. The rejection by compatibility shows that the identical had the lower rejection rate (10%). The haploidentical group without induction had the highest rejection rates (53.3%). In all distinct group the rejection rates were similar with basiliximab or Thymoglobulin, p = NS. The use of induction therapy was associated independently with a lower risk of rejection (OR = 0.32 CI: 0.11 to 0.93, p = 0.036). There were no differences in renal function at 6 months and patient survival and graft in the three groups. Discussion: The haploidentical patients without induction were those with higher rates of acute rejection. The group of patients induced with Thymoglobulin had a higher immunological risk, however showed low rates of rejection. Conclusion: The use of induction therapy resulted in lower rates of rejection in transplantation with living donor.
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Pós-graduação em Agronomia (Proteção de Plantas) - FCA
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Pós-graduação em Microbiologia - IBILCE
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Pós-graduação em Agronomia (Genética e Melhoramento de Plantas) - FCAV
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The objective of this study was to assess families and highlight the superior progenies of sugarcane originating from 38 biparental crosses for the following attributes: tons of cane per hectare (TCH), tons of biomass per hectare (TBIOH), brix (% cane juice), fiber content, purity, pol and total recoverable sugar (TRS). The data were analyzed by mixed model REML / BLUP in the REML (Restricted Maximum Likelihood) allowed us to estimate genetic parameters and BLUP (best linear unbiased prediction) to predict the additive and genotypic values. The best family for the attributes TCH and TBIOH was 41, whose parents are cultivars IACSP022019 x CTC9. In individual selection for TCH, the plant number 3 of Block 2, the crossing 78, showed the best results. To TBIOH the plant number 33, Block 1, family 41, showed the best results. Families 40, 41, 43, 68, 69, 79, 91, 92 and 147, were higher for the variables brix, pol, purity, and ATR, where as 85 families, 147, 148, 149, 161, 163, 177, 178, 179, and 183 were higher for fiber. The family 147 whose parents are IACSP042286 x IACSP963055, showed three progenies ranked among the top ten for both brix, and for fiber, which identifies the combination as a potential source of progenies for bioenergy production.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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The free-end removable partial dentures (RPD) shows a complicated and peculiar biomechanical behavior that impose high occlusion forces to the abutment teeth. By this way, the aim of this study was to evaluate the several factors that influence the clasps indication to free-end RPD. It was analysed 84 designed and planned study models of 71 patients, involving 130 clasps near-by a free-end; followed by clinical and radiographical informations. It was observed that bar clasps (“T”, “Tmod”, “i”) were used in 88.46% of abutment teeth. In the others (11.55%), it was used simple, combinated or ring circumferential clasps, and MDL. In abutment teeth with high equator line the “i” clasps were predominant (48.48%). The “Tmod” clasps were predominant in abutment teeth with low equator line (50%) or in middle third (51.35%) and “T” clasps were predominant in inclined equators with mesio-buccal (56.52%) or disto-buccal (66.66%) retention. In the posterior abutment teeth, it was prevalent the distal rest (63.52%) and embracing to the adjacent tooth. Some others factors like long clinical crown (5.38%), wrong position of abutment teeth (4.61%), aesthetics (3.07%), retention in alveolar ridge (2.3%), fragility of abutment teeth (1.53%), short clinical crown (0.76%) and short space to the clasp (0.76%) influenced directly during the clasps selection. Factors like mobility of abutment teeth, height of muscular insertions, depth of buccal fornix and antagonist arch acted like secondary factors. After the informations analysis it may be concluded that the bar clasps with distal rest and embracing to the adjacent tooth were the most indicated to free-end RPD