Development and validation of a stability-indicative turbidimetric assay to determine the potency of doxycycline hyclate in tablets

The doxycycline (DOX) is a broad-spectrum antibiotic used in several countries. This drug is part of the list of medicines to the SUS (Unified Health System), a model of health care in Brazil. This study describes the development and validation of a microbiological assay, applying the turbidimetric method for the determination of DOX, as well as the evaluation of the ability of the method in determining the stability of DOX in tablets against acidic and basic hydrolysis, photolytic and oxidative degradations, using Escherichia coli ATCC 10536 as micro-organism test and 3×3 parallel line assay design, with nine tubes for each assay, as recommended by the Brazilian Pharmacopoeia. The developed and validated method showed excellent results of linearity, selectivity, precision, accuracy and robustness. The assay is based on the inhibitory effect of DOX using Escherichia coli ATCC 10536. The results of the assay were treated by analysis of variance and were found to be linear (r= 0.9986) in the range from 4.0 to 9.0μg/mL, precise (repeatability R.S.D.= 0.99 and intermediate precision was confirmed by statistical analysis the mean values obtained from analysis by different analysts) and exact (97.73%). DOX solution exposed to direct UV light, alkaline and acid hydrolysis and hydrogen peroxide causing oxidation were used to evaluate the specificity of the bioassay. Comparison of bioassay and liquid chromatography showed differences in results between methodologies. The results showed that the bioassay is valid, simple and useful alternative methodology for DOX determination in routine quality control.

Doxycycline hyclate: a review of properties, applications and analytical methods

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Notificação de violência contra criança: conhecimento e comportamento dos profissionais de saúde

Introduction: The violence against children and teenagers severely damages physical health and psychological development of their victims. Health professionals are in a strategic position to detect cases of assault and legally obliged to report such cases, even suspected. Objectives: This study aimed to assess the knowledge of health professionals who work in the National Health System (SUS) on reporting of violence against children and adolescents. Methods: We conducted interviews with 54 primary care team of four cities from the region of São José do Rio Preto. Results: Through the study could be seen that 92.6% of respondents suspected or witnessed violence against children exercising their profession in the SUS. About Order 1968/2001, 75.5% of practitioners claim ignoring it. 96.2% were not informed about completing the notification form of violence. 88.9% do not know about the existence of the same workplace. The association between obtaining information on work and the act of notification was significant (p = 0.0276). Conclusion: The professionals are still unaware of the legal issues related to notification. It is suggested that the training of them to deal with the bureaucratic side of the issue, once notify contributes to the delineation of the epidemiology of violence and consequent development of public policies

O conhecimento das funções e a formação dos auxiliares odontológicos atuantes no serviço público de saúde de municipios do noroeste paulista

The aim of this study was to evaluate the knowledge of Hygienists (TSB) and Dental Auxiliaries (ASB) in relation to their roles regulated by Law number 11.889, December 24th, 2008, and formation of them and capacitating received before they had been admitted in public health system. It’s a transversal and descriptive study where the target population were TSB and ASB (N=76) that works in public service from 5 cities of the DRS II-SP. Data collection was performed by semi-structured instrument with opened and closed questions. The answer rate was 90.79% (n=69). The results showed that the majority of professional know part of their duties (56%) Near half of them had formation course (47.8%). In relation to information received during formation courses, 80% stated had received all information necessary to actualization of knowledge, however, 84% stated to feel necessity to actualize their knowledge to develop their works, 58% of professionals said that they don’t receive capacitating after they had been admitted. It was possible to conclude that the majority of professionals know part of their roles, has formation course and the majority don’t receive capacitating when they are admitted in public health system, however, it was observed that a part of them don’t have specific formation yet and don’t know part of their roles according to current legislation

O conhecimento dos auxiliares odontológicos do sistema público de saúde dos municípios do noroeste paulista sobre os aspectos bioéticos na prática profissional

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Honorários praticados por operadoras de planos odontológicos e pelo SUS em relação aos definidos pelo Conselho Federal de Odontologia

Aim: The present study investigated the fees paid by dental insurance companies to dental surgeons, referrent to groups of dental procedures. Materials and Methods: The fees offered by dental insurance companies were defined according to the average values from the price tables of 5 insurance plans that offered national coverage. These average values and the values paid by the Brazilian Unified Health System (SUS) were compared with those set forth in the VRCC table from Brazilian Federal Dental Council (CFO). For comparison, average values were obtained for the following groups of procedures: preventive, aesthetic, endodontic, and surgical. The values of these preventive procedures were compared with other groups of procedures. Results: The plans applied an average discount of approximately 54.51% upon the prices suggested in the CFO price list. The highest discount was observed within the group of preventive procedures (57.09%, on average). Conclusion: The evaluated health insurance companies in vestigated in the present study are applying an abusive discount upon the prices suggested in the CFO price list. It's necessary to identify alternatives to reverse this situation.

Avaliação da sensibilidade à insulina e concentração do cortisol salivar em gestantes com doença periodontal

Pós-graduação em Odontologia Preventiva e Social - FOA

Atenção farmacêutica em idosos com hipertensão participantes da estratégia saúde da família

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Acesso aos níveis de atenção à saúde em um município do Estado de São Paulo: perspectivas de gestores, profissionais e usuários

Pós-graduação em Saúde Coletiva - FMB

Avaliação e resolutividade do serviço odontológico no Sistema Único de Saúde

Pós-graduação em Odontologia Preventiva e Social - FOA

Aspectos sociodemográficos e epidemiológicos dos casos de hanseníase em uma área endêmica: conhecimentos e experiências de cirurgiões-dentistas

Pós-graduação em Odontologia Preventiva e Social - FOA

Nível de atividade física no lazer em usuários do Sistema Único de Saúde

Although leisure physical activity has been investigated in general population, there is absence of data in Brazilian Public Health System about this issue. Thus, the purpose of this study was to analyze in patients attended by Public Health System the prevalence of leisure physical activity, as well as, to identify its correlates and associated diseases. Sample was composed by 963 patients (707 female and 256 male) randomly selected at five basic healthcare units. Leisure physical activity was assessed by Baecke’s questionnaire and subjects with ≥180 and ≥240 minutes per week were classified as sufficiently active. General and central obesity were assessed by body mass index and waist circumference, respectively. Diseases of high occurrence were classified according CID-10. There was low rate of physically active subjects in leisure time (14.8%),but high rate of abdominal obesity (70.1%) and orthopedic diseases (72.1%). Physically active subjects in leisure time had lower occurrence of orthopedic diseases (OR= 0.60 [OR95%CI: 0.37 – 0.98]). The same pattern of association was observed for central obesity (OR= 0.35 [OR95%CI: 0.19 – 0.65]). It is low the rate of physically active in leisure time at Brazilian Public Health System, which is associated with orthopedic diseases.

Trabalho multiprofissional: necessidades reais e as políticas públicas na atenção da população idosa

Concomitant with the aging process there is an increasing of incidence of chronic diseases. So, it emerges the need for adaptation in the health system that requires new skills of healthcare professionals in order to serve this population. Therefore, it is necessary to understand the aging process and establish preventive measures. These issues are still far from achieving the ideal, however, many government programs and universities have sought to improve themselves and adapt to this change through a plurality of actions and preventive or health promotion intervention which provide a more resolute and humanized care plan through a multidisciplinary approach.

Ação de vigilância em acidentes do trabalho com o uso Modelo de Análise e Prevenção de Acidentes (MAPA) em Piracicaba/SP

Pós-graduação em Saúde Coletiva - FMB

Vivências anímicas e percepção subjetiva de qualidade de vida: perspectiva de servidores públicos nos âmbitos da saúde e da educação

This study was qualitative in nature and aimed to investigate the possible interference of spiritual experiences with the subjective perception of quality of life. The perspectives of civil servants in education and health services were compared. The study was developed through bibliographic and exploratory research, and the instrument used for data collection for the exploratory research was the WHOQOL-bref, which was applied in two stages: before and after experiences with spiritual activities. The purposive sample used in this study was composed of civil servants working in health and education administrative sectors of the Brazilian Unified Health System and a State University, respectively, with the intention of broadening the understanding about the perception of quality of life in civil servants from different sectors. The exploratory research of the study was carried out in three stages. The first was a two-phase data collection, before and after experiences with spiritual activities offered to civil servants who worked in the health care field, as well as the analysis of the results of this step. The second stage was the collection of data before and after experiences with spiritual activities offered to civil servants who worked in the administrative sector of education in a public university, besides the analysis of the results of this step. The third stage consisted of a comparison of the results obtained in the preceding two steps. The data resulting from the use of the research instrument for both samples were analyzed via Thematic Content Analysis. A questionnaire containing 26 questions based on four main themes was used. The first two questions were related to perceived quality of life and health satisfaction and they were not part of the specific domains. The other 24 questions were divided between the four themes: physical domain, psychological domain, domain of social relations, and environmental domain. The results...