Expressão do mRNA do gene Capn 2 e índice de apoptose de ilhotas pancreáticas de rato tratadas com fibrilas de amilina e com oligômeros de amilina de tamanho intermediário

O depósito de amilina é um achado histopatológico freqüente em pacientes portadores de diabetes melito tipo 2 (DM 2) e parece estar relacionado à disfunção da célula beta pancreática característica desta doença. Apenas as moléculas de amilina que sofrem agregação in vivo, tal como a amilina humana, são citotóxicas para as células beta, enquanto as variedades não agregantes, como a amilina de rato, não apresentam efeito deletério. Com o objetivo de compreender melhor os mecanismos de toxicidade associados à forma agregante da amilina, um projeto em andamento em nosso laboratório estudou, por micro-arranjos de cDNA, o perfil de genes modulados pela amilina humana em ilhotas pancreáticas murídeas, comparando duas situações específicas: ilhotas tratadas com fibrilas de amilina (“amilina madura”) e ilhotas tratadas com oligômeros de tamanho intermediário (“amilina fresca”), já que evidências recentes apontam para um efeito deletério apenas de oligômeros de amilina. As ilhotas foram isoladas a partir de ratos Wistar, mantidas em cultura por 24 horas e a seguir tratadas com 10

O Sistema de Gestão Ambiental e sua contribuição socioambiental para a biblioteca central da UNESP, Campus Rio Claro/SP

The minimization and mitigation of environmental impacts caused by the activities of organizations is increasingly becoming a key concern due to factors such as market demand, including suppliers and consumer markets, quality standards and even marketing strategies. The implementation of an EMS - Environmental Management System - allows the organization to achieve the level of environmental performance for its determined and promotes continuous improvement over time. This system consists of a schedule of activities, so as to eliminate or minimize impacts to the environment through preventive actions. It also provides a structured approach to set and achieve goals and objectives, and to establish procedures, work instructions and control, ensuring that the implementation of the policy can become reality. The objective of this work consists in planning a system using environmental management based on the ISO 14001 - standard internationally more widespread and accepted in the requirements to establish and operate an EMS - the Central Library, UNESP, Rio Claro / SP to stimulate the quest for continuous improvement and sustainability in the educational institution. For making the diagnosis of this planning was used the PDCA methodology, suggested by the standard, as well as all requirements for compliance. The results show that the benefits that the organization will receive involve reducing expenses and cost of energy and water, and improve the organization's reputation before the whole university and other educational institutions, reaching about three thousand people on university

O regime de metas inflacionárias e sua adequação à economia brasileira

The Inflation Targeting Regime was adopted in Brazil in 1999 and it aims at maintaining the price level in the interval set by the government. For such reason, the Central Bank makes use of variations in the interest rate, which causes the cost of the credit to be more expensive, reducing the investments, the jobs and, concomitantly, the inflation. Being aware that the country is subject to sudden reversals of the international capital flows which results in exchange rate and price instability, an econometric analysis of the adequation of the targerting regime to the Brazilian economy, especially concerned with the index price that is used as the parameter for the inflation calculus, is proposed

Chuva, vulnerabilidade social e percepção do risco na cidade de São Paulo: impactos de eventos extremos nos bairros da Freguesia do Ó e do M’Boi Mirim

The city of São Paulo has, since the beginning of the expansion of its urban sprawl, represented relations of conflicts and contradictions between society and nature. Once the way society relates to nature is defined by how the social agents themselves correlate in certain social and historical contexts, the ways of interaction between the social and natural elements will be different according to the forms of production and appropriation of the urban space. Even more evident is the case of the great national metropolis, given its demographic dimensions and historical conditions, the process of urban expansion follows a logic where spaces of better quality for housing are occupied by those of better financial conditions. Thus, although there are exceptions, the poorest people live in places less desirable, in less resilient environments of lower environmental quality, relating to nature and its phenomena with greater risks. These risks are reflected here as recurring flooding, mudslides and landslides for which the rain is constantly blamed. So we have a situation where it is clear that a weather phenomenon differently interacts with different social groups. In this context, the study was conducted to compare extreme events occurred in two regions of São Paulo: the Freguesia do O, in the north side, and M'Boi Mirim, in the south side. Both are regions with large number of risk areas and are in the same urban climate unit. However, they present different conditions of social vulnerability. With the investigation of each extreme rain event occurred in the two regions, in the period of 2000-2010, supplemented by field research, we tried to observe how far the rain, with his intensity and volume, can, in fact, be related to the accidents.

Qualidade de vida e vulnerabilidade social na percepção do idoso

According to data from the World Health Organization, the older population will grow sixteenfold from 1950 to 2025 in comparison to a fivefold population growth in the same period, which is referred to by UNO as the “Ageing Era”. This places Brazil in the sixth position in the contingent of older individuals worldwide, with a number that is higher than 32 million. Considering how topics such as quality of life and social vulnerability are important in face of the growing older population, these topics must be furthered studied so that they can be understood as important variables for both better clinical practice and scientific research. To describe the social vulnerability and evaluate the quality of life of older individuals in a population hospitalized in the internal medicine ward of Bauru State Hospital. This is a descriptive qualitative study that was conducted by means of interviews and using Bardin’s discourse analysis. The inclusion criteria used in this study were: individuals at 60 years of age who were mentally capable of answering the proposed questions. Two categories concerning Quality of Life and Social Vulnerability emerged from the interviews. The following emerged from the theme Quality of Life: “Life as something important” and subcategories that involved feeling useful in society, having a supportive family, independence, optimism and joy and survival. Also, the following emerged from the theme Social Vulnerability: “Negative recognition of older individuals in society” and subcategories that involved lack of respect, functional disability, family indifference, housing-related insecurity, an inefficient health care system and loneliness. Quality of Life and Social Vulnerability are largely discussed themes in the present scenario. In this study, it was possible to perceive that the older population needs social support, effective public... (Complete abstract click electronic access below)

Regiões competitivas agrícolas e vulnerabilidade territorial: o papel do Consórcio Pesquisa Café

This academic work presents the final results of the undergraduate research about new agricultural technical systems developed by “Consórcio Pesquisa Café” (CPC), which main objective was to analyze the impacts of scientific inputs in different coffee producing regions, particularly in South of Minas Gerais. The creation of the CPC meets the demands of a global scientific coffee-growing (SANTOS, 2000) under development in the current period technical-scientific-informational (SANTOS, 2009). On this period, also called globalization, the technoscience, the information and the finances guide the actions of companies and institutions submitted by imperative of competitiveness on international market. The Brazilian’s coffee-growing regions (South of Minas Gerais, Cerrado Mineiro, Espírito Santos Ridge’s, Western Bahia, among others) on search of higher productivities, begin gather technical, informational and communicational densities (SANTOS, 2009). Considering these facts, we detail in this research, the major agricultural technical systems developed by “Consórcio Pesquisa Café” (CPC), expressed in new management techniques, new cultivars and new chemicals, mechanical and biological inputs. In the concluding part of this undergraduate research we analyze how these new technical systems contribute to increased competitiveness and vulnerability of South of Minas Gerais in front of international market

Sustentabilidade socioambiental e a certificação de produtos orgânicos no estado de São Paulo

A produção de alimentos orgânicos no Brasil vem aumentando de maneira expressiva e tende a crescer ainda mais nos próximos anos, visto que a regulamentação da agricultura orgânica e seu marco legal são muito recentes. Considerando-se os problemas relacionados à agricultura convencional e o papel que a agricultura orgânica assume como alternativa ao sistema de produção vigente, o presente estudo tem como objetivo principal realizar uma revisão bibliográfica sobre a sustentabilidade do sistema orgânico de produção em seus aspectos técnicos, ecológicos, econômicos, socioculturais e políticos, comparativamente ao sistema de produção convencional. Além disso, buscou-se traçar um panorama atualizado sobre o mercado e a produção de alimentos orgânicos no Brasil e no Estado de São Paulo, de maneira a evidenciar os principais entraves à expansão da agricultura orgânica no país, enfocando especialmente os processos de certificação.

Uso e ocupação da terra e vulnerabilidade a alagamento na área central da cidade de São Paulo: o caso da subprefeitura Sé

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

O debate modernidade / pós-modernidade e a crise socioambiental: um estudo sobre teses e dissertações brasileiras em educação ambiental

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Métodos econométricos para a análise do índice de inflação no Brasil

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Responsabilidade socioambiental e o balanço social

Este trabalho tem como objetivo trazer uma discussão sobre o tema da Responsabilidade Social, que embora esteja em evidência nos últimos anos, ainda apresenta campos a serem explorados, especialmente pelo mercado consumidor. Além disso, visa simplificar, ainda que superficialmente, a complexidade com que um relatório socioeconômico muitas vezes é tratado, de forma a indicar caminhos mais práticos e didáticos para que os mais diversos públicos tenham acesso e sejam capazes de aperfeiçoar suas leituras e interpretações acerca dos indicadores que constam em documentos desta natureza

Um estudo sobre Projovem Adolescente e seus impactos sobre as condições de trabalho e vulnerabilidade das jovens do sexo feminino no município de Barretos/SP

Pós-graduação em Serviço Social - FCHS

Prospecção de marcadores microssatélites, análise de viriabilidade e estrutura genética populacional de arara-azul-grande Anodorhynchus hyacinthinus (Latham, 1790) com ênfase na região do mosaico dos Carajás-PA

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O Serviço Social e a avaliação de impacto na gestão de programas e projetos empresariais

Pós-graduação em Serviço Social - FCHS

Raia Divisória ou Raia Socioambiental?: uma redefinição baseada na análise da paisagem através do sistema GTP

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)