Metalloproteinases-2 and -9 predict left ventricular remodeling after myocardial infarction

Background: The role of serum metalloproteinases (MMP) after myocardial infarction (MI) is unknown. Objective: The aim of this study was to evaluate the role of serum MMP-2 and -9 as predictors of ventricular remodeling six months after anterior MI. Methods: We prospectively enrolled patients after their first anterior MI. MMP activity was assayed 12 to 72 hours after the MI. An echocardiogram was performed during the hospitalization and six months later. Results: We included 29 patients; 62% exhibited ventricular remodeling. The patients who exhibited remodeling had higher infarct size based on creatine phosphokinase (CPK) peak values (p = 0.037), higher prevalence of in-hospital congestive heart failure (p = 0.004), and decreased ejection fraction (EF) (p = 0.007). The patients with ventricular remodeling had significantly lower serum levels of inactive MMP-9 (p = 0.007) and significantly higher levels of the active form of MMP-2 (p = 0.011). In a multivariate logistic regression model, adjusted by age, CPK peak, EF and prevalence of heart failure, MMP-2 and -9 serum levels remained associated with remodeling (p = 0.033 and 0.044, respectively). Conclusion: Higher serum levels of inactive MMP-9 were associated with the preservation of left ventricular volumes, and higher serum levels of the active form of MMP-2 were a predictor of remodeling 6 months after MI. (Arq Bras Cardiol. 2013;100(4):315-321).

Fatores associados aos componentes de aptidão e nível de atividade física de usuários da Estratégia de Saúde da Família, Município de Botucatu, Estado de São Paulo, Brasil, 2006 a 2007

Fundo de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Perda de matéria seca em grãos de milho submetidos a sistemas de secagem natural e artificial.

The permanence of the corn grain in the field, after physiological maturity, is an important cause of crop losses, both in quantitative and qualitative aspect. By ceasing the supply of assimilated substances to grains, due to physiological maturity, the synthesis reactions are overcome by breathing, responsible for the maintenance of the living tissues of the grains, which occur at the expense of reserves accumulated during grain formation. In addition, there are losses from fungus and insects attack due to adverse weather conditions. Technological advances in recent decades, the develop of grain dryers with different capacities and efficiencies, has led to the early withdrawal of the product from the field, still damp, reducing spoilage. Moreover, the use of artificial drying systems can represent a significant cost to the producer. Thus, the present work aimed to study the effect of natural and artificial methods of drying on maize dry matter losses, for Botucatu, city of Sao Paulo state, Brazil. The cornfield production was conducted at the Experimental Farm “Lageado” and the experimental treatments were conducted in the Laboratory of Agricultural Products Processing, in the Department of Rural Engineering, where the drying systems were tested. The treatments were: shade (control), artificial with heated air, artificial unheated air and, drying attached to the plant. The following analyzes for quality monitoring were performed: weight test, thousand-grain weight test and, grain dry weight. The results showed significant loss in quality of drying beans attached to the plant, by assessing the dry matter loss and by the variation of the grain weight. The weight test showed that the worst performance was the artificial with heated air treatment. We used mathematical modeling techniques to describe the dry matter loss and adjusted the mathematical model to the experimental data analyzed. From the experimental data obtained during drying the grain attached to the plant, it was still possible to fit a regression model that estimates the loss of grain dry matter under the climate from Botucatu during the 2011/2012 harvest period.

Avaliação das ações de alimentação e nutrição na atenção primária a saúde no estado de São Paulo

Pós-graduação em Alimentos e Nutrição - FCFAR

Seleção genômica para características longitudinais de bovinos da raça Holandesa

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Fatores dietéticos, antropométricos e socioeconômicos associados à sarcopenia em idosos: estudo transversal de base populacional

Pós-graduação em Saúde Coletiva - FMB